Intensive Care Medicine

, Volume 32, Issue 4, pp 490–500 | Cite as

Year in review in intensive care medicine, 2005. III. Nutrition, pediatric and neonatal critical care, and experimental

  • Peter Andrews
  • Elie Azoulay
  • Massimo Antonelli
  • Laurent BrochardEmail author
  • Christian Brun-Buisson
  • Geoffrey Dobb
  • Jean-Yves Fagon
  • Herwig Gerlach
  • Johan Groeneveld
  • Jordi Mancebo
  • Philipp Metnitz
  • Stefano Nava
  • Jerome Pugin
  • Michael Pinsky
  • Peter Radermacher
  • Christian Richard
  • Robert Tasker
Year in Review 2005


The potential benefit of enteral immunonutrition remains uncertain and controversial despite numerous previous studies. Kieft and colleagues [1] completed another clinical trial in two ICUs. Strengths of their study are the randomized, double-blind design, inclusion of 597 adult ICU patients, and intention-to-treat analysis. The control feeds were isocaloric but the “immunonutrition” (Stresson Multi Fibre, Nutricia) had a higher total protein content. Immunonutrition had no effect on patient outcome regardless of whether assessed on a intention-to-treat or per-protocol basis. The authors also carried out post-hoc subgroup analyses in groups of interest: those with sepsis and Acute Physiology and Chronic Health Evaluation (APACHE) II scores of 10–20. Patients with sepsis are thought to be harmed by arginine-supplemented feeds, but no statistically significant difference was found in the small group (n = 30) of patients with sepsis. It is suggested midrange APACHE II score...


Continuous Positive Airway Pressure Pediatric Intensive Care Unit Acute Hepatic Failure Molecular Adsorbent Recirculate System Continuous Distend Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Peter Andrews
    • 2
  • Elie Azoulay
    • 3
  • Massimo Antonelli
    • 4
  • Laurent Brochard
    • 1
    Email author
  • Christian Brun-Buisson
    • 1
  • Geoffrey Dobb
    • 5
  • Jean-Yves Fagon
    • 6
  • Herwig Gerlach
    • 7
  • Johan Groeneveld
    • 8
  • Jordi Mancebo
    • 9
  • Philipp Metnitz
    • 10
  • Stefano Nava
    • 11
  • Jerome Pugin
    • 16
  • Michael Pinsky
    • 12
  • Peter Radermacher
    • 13
  • Christian Richard
    • 14
  • Robert Tasker
    • 15
  1. 1.Réanimation MédicaleAP-HP, Hôpital Henri MondorParis 12France
  2. 2.Intensive Care UnitWestern General HospitalEdinburghUK
  3. 3.Intensive Care UnitSaint Louis HospitalParisFrance
  4. 4.Department of Intensive Cure and AnesthesiologyUniversita Cattolica del Sacro CuoreRomeItaly
  5. 5.Intensive Care UnitRoyal Perth HospitalPerth,Australia
  6. 6.Intensive Care UnitEuropean Georges Pompidou HospitalParisFrance
  7. 7.Department of AnesthesiologyVivantes-Klinikum NeukoellnBerlinGermany
  8. 8.Intensive Care UnitVUMCAmsterdamThe Netherlands
  9. 9.Intensive Care UnitHospital Sant PauBarcelonaSpain
  10. 10.Department of Anesthesia and General Intensive Care MedicineUniversity Hospital of ViennaViennaAustria
  11. 11.Intensive Care UnitFondazione S. MaugeriPaviaItaly
  12. 12.Intensive Care UnitUniversity of Pittsburgh Medical CenterPittsburghUSA
  13. 13.Department of AnesthesiaUniversity Medical School of UlmUlmGermany
  14. 14.Intensive Care UnitUniversity Hospital of Le Kremlin-BicetreLe Kremlin BicetreFrance
  15. 15.Pediatric Intensive Care UnitAddenbrook's HospitalCambridgeUK
  16. 16.Intensive Care UnitUniversity Hospital of GenevaGenevaSwitzerland

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