Intensive Care Medicine

, Volume 32, Issue 1, pp 75–79

Statin therapy is associated with fewer deaths in patients with bacteraemia

  • Peter Kruger
  • Kenneth Fitzsimmons
  • David Cook
  • Mark Jones
  • Graeme Nimmo
Original

Abstract

Objective

Beneficial effects with statin use are increasingly reported in a variety of patient groups. There is in vitro and clinical evidence for its antiinflammatory and immunomodulatory therapeutic roles. We aimed to assess the association between statin administration and mortality in bacteraemic patients.

Design

A retrospective cohort analysis.

Setting

A 300-bed acute general hospital.

Patients and participants

All patients (n=438) requiring hospital care for an episode of bacteraemia during the years 2000–2003 were included. Statin use, patient outcome, and clinical and laboratory variables were collected.

Interventions

None.

Measurements and results

There was a significant reduction in all-cause hospital mortality (10.6% vs. 23.1%, p=0.022) and death attributable to bacteraemia (6.1% vs. 18.3%, p=0.014) in patients who were receiving statin therapy at the time of bacteraemia (n=66). The reduction in all-cause hospital mortality (1.8% vs. 23.1%, p=0.0002) and death attributable to bacteraemia (1.8% vs. 18.3%, p=0.0018) was more pronounced in the patients who continued to receive statin therapy after the diagnosis of bacteraemia (n=56). The apparent mortality benefit persisted after controlling for differences between the groups. Statin use prior to admission was associated with a reduced adjusted hospital mortality rate (odds ratio 0.39; CI 95% 0.17, 0.91; p=0.029), and continuing statin use after bacteraemia increased this effect (odds ratio 0.06; CI 95% 0.01, 0.44; p=0.0056).

Conclusion

This retrospective study demonstrates a significant survival benefit associated with continuing statin therapy in bacteraemic patients. The potential for statins as an adjuvant therapy in sepsis warrants further investigation.

Keywords

HMG-CoA reductase inhibitor Statin Bacteraemia Mortality 

Supplementary material

supp.pdf (337 kb)
(PDF 338 KB)

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Peter Kruger
    • 1
  • Kenneth Fitzsimmons
    • 2
  • David Cook
    • 1
  • Mark Jones
    • 3
  • Graeme Nimmo
    • 4
  1. 1.Intensive Care UnitPrincess Alexandra HospitalBrisbaneAustralia
  2. 2.Department of AnaesthesiaIpswich HospitalAustralia
  3. 3.Queensland Clinical Trials CentreUniversity of QueenslandAustralia
  4. 4.Division of Microbiology, Queensland Health Pathology ServicePrincess Alexandra HospitalBrisbaneAustralia

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