Intensive Care Medicine

, Volume 32, Issue 1, pp 24–33 | Cite as

Ventilator-induced lung injury: from the bench to the bedside

Seminal Study

References

  1. 1.
    Baker AB (1971) Artificial respiration, the history of an idea. Med Hist 15:336–351PubMedGoogle Scholar
  2. 2.
    Champneys FH (1887) Expiratory cervical emphysema, that is, emphysema of the neck occurring during labour and during violent expiratory efforts. In: Experimental researches in artificial respiration in stillborn children, and allied subjects. Lewis, LondonGoogle Scholar
  3. 3.
    Macklin CC (1939) Transport of air along sheaths of pulmonic blood vessels from alveoli to mediastinum. Arch Intern Med 64:913–926Google Scholar
  4. 4.
    Greenfield LJ, Ebert PA, Benson DW (1964) Effect of positive pressure ventilation on surface tension properties of lung extracts. Anesthesiology 25:312–316PubMedGoogle Scholar
  5. 5.
    Faridy EE, Permutt S, Riley RL (1966) Effect of ventilation on surface forces in excised dogs’ lungs. J Appl Physiol 21:1453–1462PubMedGoogle Scholar
  6. 6.
    Fowler WS (1949) Lung function studies 3. Uneven pulmonary ventilation in normal subjects and in patients with pulmonary disease. J Appl Physiol 2:283–299PubMedGoogle Scholar
  7. 7.
    Mead J, Takishima T, Leith D (1970) Stress distribution in lungs: a model of pulmonary elasticity. J Appl Physiol 28:596–608PubMedGoogle Scholar
  8. 8.
    Ashbaugh DG, Bigelow DB, Petty TL, Levine BE (1967) Acute respiratory distress in adults. Lancet II:319–323CrossRefGoogle Scholar
  9. 9.
    Evans T, Cranshaw J (2003) Lung Injury. In: Fink M, Hayes M, Soni N (ed) Classic papers in critical care. Bladon, Oxfordshire, pp 31–58Google Scholar
  10. 10.
    Webb HH, Tierney DF (1974) Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure. Am Rev Respir Dis 110:556–565PubMedGoogle Scholar
  11. 11.
    Dreyfuss D, Basset G, Soler P, Saumon G (1985) Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats. Am Rev Respir Dis 132:880–884PubMedGoogle Scholar
  12. 12.
    Dreyfuss D, Soler P, Basset G, Saumon G (1988) High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 137:1159–1164PubMedGoogle Scholar
  13. 13.
    Dreyfuss D, Saumon G (1998) Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 157:294–323PubMedGoogle Scholar
  14. 14.
    Bouhuys A (1969) Physiology and musical instruments. Nature 221:1199–1204PubMedGoogle Scholar
  15. 15.
    West JB, Tsukimoto K, Mathieu-Costello O, Prediletto R (1991) Stress failure in pulmonary capillaries. J Appl Physiol 70:1731–1742PubMedGoogle Scholar
  16. 16.
    Parker JC, Ivey CL, Tucker JA (1998) Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lungs. J Appl Physiol 84:1113–1118CrossRefPubMedGoogle Scholar
  17. 17.
    Parker JC, Ivey CL, Tucker A (1998) Phosphotyrosine phosphatase and tyrosine kinase inhibition modulate airway pressure-induced lung injury. J Appl Physiol 85:1753–1761PubMedGoogle Scholar
  18. 18.
    Muscedere JG, Mullen JB, Gan K, Slutsky AS (1994) Tidal ventilation at low airway pressures can augment lung injury. Am J Respir Crit Care Med 149:1327–1334PubMedGoogle Scholar
  19. 19.
    Slutsky AS (1999) Lung injury caused by mechanical ventilation. Chest 116:9S-15SCrossRefGoogle Scholar
  20. 20.
    Hernandez LA, Coker PJ, May S, Thompson AL, Parker JC (1990) Mechanical ventilation increases microvascular permeability in oleic acid-injured lungs. J Appl Physiol 69:2057–2061PubMedGoogle Scholar
  21. 21.
    Coker PJ, Hernandez LA, Peevy KJ, Adkins K, Parker JC (1992) Increased sensitivity to mechanical ventilation after surfactant inactivation in young rabbit lungs. Crit Care Med 20:635–640PubMedGoogle Scholar
  22. 22.
    Adkins WK, Hernandez LA, Coker PJ, Buchanan B, Parker JC (1991) Age effects susceptibility to pulmonary barotrauma in rabbits. Crit Care Med 19:390–393PubMedGoogle Scholar
  23. 23.
    Dreyfuss D, Soler P, Saumon G (1995) Mechanical ventilation-induced pulmonary edema. Interaction with previous lung alterations. Am J Respir Crit Care Med 151:1568–1575PubMedGoogle Scholar
  24. 24.
    Verbrugge SJ, Lachmann B (1998) Mechanisms of ventilation-induced lung injury and its prevention: role of surfactant. Appli Cardiopulm Pathophysiol 7:173–198Google Scholar
  25. 25.
    Vlahakis NE, Hubmayr RD (2005) Cellular stress failure in ventilator injured lungs. Am J Respir Crit Care Med 171:1328–1342CrossRefPubMedGoogle Scholar
  26. 26.
    Hamilton PP, Onayemi A, Smyth JA, Gillan JE, Cutz E, Froese AB, Bryan AC (1983) Comparison of conventional and high-frequency ventilation: oxygenation and lung pathology. J Appl Physiol 55:131–138PubMedGoogle Scholar
  27. 27.
    Kawano T, Mori S, Cybulsky M, Burger R, Ballin A, Cutz E, Bryan AC (1987) Effect of granulocyte depletion in a ventilated surfactant-depleted lung. J Appl Physiol 62:27–33PubMedGoogle Scholar
  28. 28.
    Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS (1997) Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 99:944–952PubMedGoogle Scholar
  29. 29.
    Tremblay LN, Slutsky AS (1998) Ventilator-induced injury: from barotrauma to biotrauma. Proc Assoc Am Physicians 110:482–488PubMedGoogle Scholar
  30. 30.
    Narimanbekov IO, Rozycki HJ (1995) Effect of IL-1 blockade on inflammatory manifestations of acute ventilator-induced lung injury in a rabbit model. Exp Lung Res 21:239–254PubMedGoogle Scholar
  31. 31.
    Uhlig S, Uhlig U (2004) Pharmacological interventions in ventilator-induced lung injury. Trends Pharmacol Sci 25:592–600CrossRefPubMedGoogle Scholar
  32. 32.
    Plotz FB, Slutsky AS, van Vught AJ, Heijnen CJ (2004) Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med 30:1865–1872CrossRefPubMedGoogle Scholar
  33. 33.
    Dreyfuss D, Rouby JJ (2004) Mechanical ventilation-induced lung release of cytokines: a key for the future or pandora’s box? Anesthesiology 101:1–3CrossRefPubMedGoogle Scholar
  34. 34.
    Kolobow T, Moretti MP, Fumagalli R, Mascheroni D, Prato P, Chen V, Joris M (1987) Severe impairment in lung function induced by high peak airway pressure during mechanical ventilation. An experimental study. Am Rev Respir Dis 135:312–315PubMedGoogle Scholar
  35. 35.
    Slutsky AS, Tremblay LN (1998) Multiple system organ failure. Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 157:1721–1725PubMedGoogle Scholar
  36. 36.
    Bethmann AN von, Brasch F, Nusing R, Vogt K, Volk HD, Muller KM, Wendel A, Uhlig S (1998) Hyperventilation induces release of cytokines from perfused mouse lung. Am J Respir Crit Care Med 157:263–272PubMedGoogle Scholar
  37. 37.
    Chiumello D, Pristine G, Slutsky AS (1999) Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. Am J Respir Crit Care Med 160:109–116PubMedGoogle Scholar
  38. 38.
    Nahum A, Hoyt J, Schmitz L, Moody J, Shapiro R, Marini JJ (1997) Effect of mechanical ventilation strategy on dissemination of intratracheally instilled Escherichia coli in dogs. Crit Care Med 25:1733–1743CrossRefPubMedGoogle Scholar
  39. 39.
    Verbrugge SJ, Sorm V, van’t Veen A, Mouton JW, Gommers D, Lachmann B (1998) Lung overinflation without positive end-expiratory pressure promotes bacteremia after experimental Klebsiella pneumoniae inoculation. Intensive Care Med 24:172–177CrossRefPubMedGoogle Scholar
  40. 40.
    Murphy DB, Cregg N, Tremblay L, Engelberts D, Laffey JG, Slutsky AS, Romaschin A, Kavanagh BP (2000) Adverse ventilatory strategy causes pulmonary-to-systemic translocation of endotoxin. Am J Respir Crit Care Med 162:27–33PubMedGoogle Scholar
  41. 41.
    Guery BP, Welsh DA, Viget NB, Robriquet L, Fialdes P, Mason CM, Beaucaire G, Bagby GJ, Neviere R (2003) Ventilation-induced lung injury is associated with an increase in gut permeability. Shock 19:559–563CrossRefPubMedGoogle Scholar
  42. 42.
    Imai Y, Parodo J, Kajikawa O, de PM, Fischer S, Edwards V, Cutz E, Liu M, Keshavjee S, Martin TR, Marshall JC, Ranieri VM, Slutsky AS (2003) Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 289:2104–2112CrossRefPubMedGoogle Scholar
  43. 43.
    Choi WI, Quinn DA, Park KM, Moufarrej RK, Jafari B, Syrkina O, Bonventre JV, Hales CA (2003) Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injury. Am J Respir Crit Care Med 167:1627–1632CrossRefPubMedGoogle Scholar
  44. 44.
    Gattinoni L, Pesenti A, Avalli L, Rossi F, Bombino M (1987) Pressure-volume curve of total respiratory system in acute respiratory failure. Computed tomographic scan study. Am Rev Respir Dis 136:730–736PubMedGoogle Scholar
  45. 45.
    Gattinoni L, Mascheroni D, Torresin A, Marcolin R, Fumagalli R, Vesconi S, Rossi GP, Rossi F, Baglioni S, Bassi F (1986) Morphological response to positive end expiratory pressure in acute respiratory failure. Computerized tomography study. Intensive Care Med 12:137–142CrossRefPubMedGoogle Scholar
  46. 46.
    Menitove SM, Goldring RM (1983) Combined ventilator and bicarbonate strategy in the management of status asthmaticus. Am J Med 74:898–901CrossRefPubMedGoogle Scholar
  47. 47.
    Darioli R, Perret C (1984) Mechanical controlled hypoventilation in status asthmaticus. Am Rev Respir Dis 129:385–387PubMedGoogle Scholar
  48. 48.
    Hickling KG, Henderson SJ, Jackson R (1990) Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome. Intensive Care Med 16:372–377CrossRefPubMedGoogle Scholar
  49. 49.
    Amato MB, Barbas CS, Medeiros DM, Schettino GP, Lorenzi FG, Kairalla RA, Deheinzelin D, Morais C, Fernandes EO, Takagaki TY (1995) Beneficial effects of the “open lung approach” with low distending pressures in acute respiratory distress syndrome. A prospective randomized study on mechanical ventilation. Am J Respir Crit Care Med 152:1835–1846PubMedGoogle Scholar
  50. 50.
    Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, Takagaki TY, Carvalho CR (1998) Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 338:347–354CrossRefPubMedGoogle Scholar
  51. 51.
    Stewart TE, Meade MO, Cook DJ, Granton JT, Hodder RV, Lapinsky SE, Mazer CD, McLean RF, Rogovein TS, Schouten BD, Todd TR, Slutsky AS (1998) Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group. N Engl J Med 338:355–361CrossRefPubMedGoogle Scholar
  52. 52.
    Brochard L, Roudot-Thoraval F, Roupie E, Delclaux C, Chastre J, Fernandez-Mondejar E, Clementi E, Mancebo J, Factor P, Matamis D, Ranieri M, Blanch L, Rodi G, Mentec H, Dreyfuss D, Ferrer M, Brun-Buisson C, Tobin M, Lemaire F (1998) Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS. Am J Respir Crit Care Med 158:1831–1838PubMedGoogle Scholar
  53. 53.
    Brower RG, Shanholtz CB, Fessler HE, Shade DM, White P Jr, Wiener CM, Teeter JG, Dodd-o JM, Almog Y, Piantadosi S (1999) Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 27:1492–1498CrossRefPubMedGoogle Scholar
  54. 54.
    Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308CrossRefPubMedGoogle Scholar
  55. 55.
    Durante G de, del Turco M, Rustichini L, Cosimini P, Giunta F, Hudson LD, Slutsky AS, Ranieri VM (2002) ARDSNet lower tidal volume ventilatory strategy may generate intrinsic positive end-expiratory pressure in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 165:1271–1274CrossRefPubMedGoogle Scholar
  56. 56.
    Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT (2004) Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 351:327–336CrossRefPubMedGoogle Scholar
  57. 57.
    Ranieri VM, Suter PM, Tortorella C, De TR, Dayer JM, Brienza A, Bruno F, Slutsky AS (1999) Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282:54–61CrossRefPubMedGoogle Scholar
  58. 58.
    Parsons PE, Matthay MA, Ware LB, Eisner MD (2005) Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol 288:L426–L431CrossRefPubMedGoogle Scholar
  59. 59.
    Spragg RG, Lewis JF, Walmrath H, Johannigman J, Bellingan G, Laterre P, Witte WC, Richards GA, Rippin G, Rathgeb F, Hafner D, Taut FJH, Seeger W (2004) Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. N Engl J Med 351:884–892PubMedGoogle Scholar
  60. 60.
    Gattinoni L, Tognoni G, Pesenti A, Taccone P, Mascheroni D, Labarta V, Malacrida R, Di GP, Fumagalli R, Pelosi P, Brazzi L, Latini R (2001) Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med 345:568–573CrossRefPubMedGoogle Scholar
  61. 61.
    Guerin C, Gaillard S, Lemasson S, Ayzac L, Girard R, Beuret P, Palmier B, Le QV, Sirodot M, Rosselli S, Cadiergue V, Sainty JM, Barbe P, Combourieu E, Debatty D, Rouffineau J, Ezingeard E, Millet O, Guelon D, Rodriguez L, Martin O, Renault A, Sibille JP, Kaidomar M (2004) Effects of systematic prone positioning in hypoxemic acute respiratory failure: a randomized controlled trial. JAMA 292:2379–2387CrossRefPubMedGoogle Scholar
  62. 62.
    Kallet RH (2004) Evidence-based management of acute lung injury and acute respiratory distress syndrome. Respir Care 49:793–809PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Department of SurgerySunnybrook and Women’s Health Sciences CenterTorontoCanada
  2. 2.Queen WingSt. Michael’s HospitalTorontoCanada
  3. 3.Interdepartmental Division of Critical Care MedicineUniversity of TorontoTorontoCanada

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