Intensive Care Medicine

, Volume 31, Issue 7, pp 898–910

Impact of selective decontamination of the digestive tract on fungal carriage and infection: systematic review of randomized controlled trials

  • Luciano Silvestri
  • Hendrik K. F. van Saene
  • Marco Milanese
  • Dario Gregori
Systematic Review

DOI: 10.1007/s00134-005-2654-9

Cite this article as:
Silvestri, L., van Saene, H.K.F., Milanese, M. et al. Intensive Care Med (2005) 31: 898. doi:10.1007/s00134-005-2654-9



To determine the impact of the antifungal component of selective decontamination of the digestive tract on fungal carriage, infection and fungaemia.


Meta-analysis of randomized controlled trials of selective decontamination of the digestive tract

Study selection

Data sources included Medline, Embase, Cochrane Register of Controlled Trials, previous meta-analyses, personal communications and conference proceedings, without restriction of language or publication status. All randomized trials were selected that compared oropharyngeal and/or intestinal administration of antifungals amphotericin B or nystatin, as part of selective decontamination protocol, with no treatment in the controls. There were 42 randomized controlled trials with a total of 6,075 critically ill patients.


Three reviewers independently applied selection criteria, performed quality assessment and extracted the data. The main outcome measures were patients with fungal carriage, patients with fungal infections and patients with fungaemia. Odds ratios were pooled with the random effect model.

Measurements and results

Enteral antifungals significantly reduced fungal carriage (odds ratio 0.32, 95% confidence interval 0.19–0.53) and overall fungal infections (0.30, 0.17–0.53). Fungaemia was not significantly reduced in the treatment group (0.89, 0.16–4.95).


Antifungals, as part of selective decontamination of the digestive tract, reduce fungal carriage and infection but not fungaemia in critically ill patients and may justify the inclusion of an antifungal component in the decontamination protocol.


Antibiotic prophylaxis Antifungal agents Carriage Selective decontamination 

Supplementary material

supp.pdf (103 kb)
(PDF 103 KB)

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Luciano Silvestri
    • 1
  • Hendrik K. F. van Saene
    • 2
  • Marco Milanese
    • 3
  • Dario Gregori
    • 4
  1. 1.Department of Emergency, Unit of Anaesthesia and Intensive Care Presidio Ospedaliero di GoriziaGoriziaItaly
  2. 2.Department of Medical MicrobiologyUniversity of LiverpoolLiverpoolUK
  3. 3.Department of Emergency, Unit of Anaesthesia and Intensive CarePresidio Ospedaliero di GoriziaGoriziaItaly
  4. 4.Department of Public Health and MicrobiologyUniversity of TurinTurinItaly

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