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Intensive Care Medicine

, Volume 31, Issue 3, pp 393–400 | Cite as

Candida spp. colonization significance in critically ill medical patients: a prospective study

  • Pierre Emmanuel Charles
  • Frédéric Dalle
  • Hervé Aube
  • Jean Marc Doise
  • Jean Pierre Quenot
  • Ludwig Serge Aho
  • Pascal Chavanet
  • Bernard Blettery
Original

Abstract

Objective

Multiple-site colonization with Candida species is commonly recognized as a major risk factor for invasive fungal infection in critically ill patients. The fungal colonization density could be of predictive value for the diagnosis of systemic candidiasis in high-risk surgical patients. Little is known about it in the medical ICU setting.

Design and setting

Prospective observational study in the eight-bed medical intensive care unit of a teaching hospital.

Subjects

92 consecutive nonneutropenic patients hospitalized for more than 7 days.

Measurements and results

The colonization index (ratio of the number of culture-positive surveillance sites for Candida spp. to the number of sites cultured) was calculated weekly upon ICU admission until death or discharge. The 0.50 threshold was reached in 36 (39.1%) patients, almost exclusively in those with detectable fungal colonization upon ICU admission. The duration of broad-spectrum antibiotic therapy was found to be the main factor that independently promoted fungal growth as measured through the colonization index.

Conclusions

Candida spp. multiple-site colonization is frequently met among the critically ill medical patients. Broad-spectrum antibiotic therapy was found to promote fungal growth in patients with prior colonization. Since most of the invasive candidiasis in the ICU setting are thought to be subsequent to colonization in high-risk patients, reducing antibiotic use could be useful in preventing fungal infections.

Keywords

Candida spp. Fungal colonization Intensive care unit Broad-spectrum antibiotic therapy Colonization index 

Notes

Acknowledgements

This research was presented at the Congress of the French Society of Critical Care Medicine, January 2004.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Pierre Emmanuel Charles
    • 1
  • Frédéric Dalle
    • 2
  • Hervé Aube
    • 1
  • Jean Marc Doise
    • 1
  • Jean Pierre Quenot
    • 1
  • Ludwig Serge Aho
    • 3
  • Pascal Chavanet
    • 4
  • Bernard Blettery
    • 1
  1. 1.Service de Réanimation MédicaleDijon University HospitalDijonFrance
  2. 2.Laboratoire de Parasitologie-MycologieDijon University HospitalDijonFrance
  3. 3.Service d’Epidémiologie et d’Hygiène HospitalièreDijon University HospitalDijonFrance
  4. 4.Service des Maladies Infectieuses et TropicalesDijon University HospitalDijonFrance

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