Intensive Care Medicine

, Volume 31, Issue 3, pp 325–326 | Cite as

ICU physicians should abandon the use of etomidate!

Editorial

References

  1. 1.
    Doenicke A (1974) Etomidate. A new intravenous hypnotic. Acta Anaesthesiol Belg 25:307–315Google Scholar
  2. 2.
    Patschke D, Bruckner JB, Gethmann JW, Tarnow J, Weymar A (1975) Comparison of the immediate effects of etomidate, propanidid, thiopentone on haemodynamics, coronary blood flow and myocardial oxygen consumption. Acta Anaesthesiol Belg 26:112–119Google Scholar
  3. 3.
    Gooding JM, Weng JT, Smith RA, Berninger GT, Kirby RR (1979) Cardiocascular and pulmonary responses following etomidate induction of anesthesia in patients with demonstrated cardiac disease. Anesth Analg 58:40–41Google Scholar
  4. 4.
    Migden DR, Reardon RF (1988) Etomidate sedation for intubation. Am J Emerg Med 16:101–102CrossRefGoogle Scholar
  5. 5.
    Paris A, Philipp M, Tonner PH, Steinfath M, Lohse M, Scholz J, Hein L (2003) Activation of α2B-adrenorecptors mediates the cardiovascular effects of etomidate. Anesthesiology 99:889–895CrossRefGoogle Scholar
  6. 6.
    Pascoe PJ, Ilkiw JE, Haskin SC, Patz JD (1992) Cardiopulmonary effects of etomidate in hypovolemic dogs. Am J Vet Res 53:2178–2182Google Scholar
  7. 7.
    Ledingham IM, Watt I (1983) Influence of sedation on mortality in critically ill multiple trauma patients. Lancet I:1270CrossRefGoogle Scholar
  8. 8.
    Wagner RL, White PF, Kan PB, Rosenthal MH, Feldman D (1984) Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med 310:1415–1421Google Scholar
  9. 9.
    Lamberts SW, Bons EG, Bruining HA, de Jong FH (1987) Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metopyrone on the secretion of cortisol and its precursors by human adrenocortical cells. J Pharmacol Exp Ther 240:259–264Google Scholar
  10. 10.
    Allolio B, Stuttmann R, Leonhard U, Fischer H, Winkelmann W (1984) Adrenocortical suppression by a single induction dose of etomidate. Klin Wochenschr 62:1014–1017Google Scholar
  11. 11.
    Malerba G, Romano-Girard F, Cravoisy A, Dousset B, Nace L, Lévy B, Bollaert PE (2005) Risk factors of relative adrenocortical deficiency in ICU patients needing mechanical ventilation. Intensive Care Med ( http://dx.doi.org/10.1007/s004-2550-8)
  12. 12.
    Absalom A, Pledger D, Kong A (1999) Adrenocortical function in critically ill patients 24 h after a single dose of etomidate. Anaesthesia 54:861–867CrossRefGoogle Scholar
  13. 13.
    Cooper MS, Stewart PM (2003) Corticosteroid insufficiency in acutely ill patients. N Engl J Med 348:727–734CrossRefGoogle Scholar
  14. 14.
    Prigent H, Maxime V, Annane D (2004) Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids. Crit Care 8:243–252CrossRefGoogle Scholar
  15. 15.
    Neumann R, Worek FS, Blumel G, Zimmermann GJ, Fehm HL, Pfeiffer UJ (1989) Cortisol deficiency in metomidate anesthetized bacteremic pigs: results in circulatory failure-beneficial effect of cortisol substitution. Acta Anaesthesiol Scand 33:379–384Google Scholar
  16. 16.
    Stuttmann R, Allolio B, Becker A, Doehn M, Winkelmann W (1988) Etomidate versus etomidate and hydrocortisone for anesthesia induction in abdominal surgical interventions. Anaesthesist 37:576–582Google Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Address Service de Réanimation, Hôpital Raymond Poincaré (AP-HP)Faculté de Médecine Paris Ile de France Ouest (UVSQ)GarchesFrance

Personalised recommendations