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Intensive Care Medicine

, Volume 32, Issue 3, pp 421–427 | Cite as

An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence in Acutely ill Patients (SOAP) study

  • Charles L. SprungEmail author
  • Yasser Sakr
  • Jean-Louis Vincent
  • Jean-Roger Le Gall
  • Konrad Reinhart
  • V. Marco Ranieri
  • Herwig Gerlach
  • Jonathan Fielden
  • C. B. Groba
  • Didier Payen
Original

Abstract

Objective

To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs

Design and setting

Cohort, multicentre, observational study of 198 ICUs in 24 European countries.

Patients and interventions

All 3,147 new adult admissions to participating ICUs between 1 and 15 May 2002 were included. Data were collected prospectively, with common SIRS criteria.

Results

During the ICU stay 93% of patients had at least two SIRS criteria [respiratory rate (82%), heart rate (80%)]. The frequency of having three or four SIRS criteria vs. two was higher in infected than non-infected patients (p < 0.01). In non-infected patients having more than two SIRS criteria was associated with a higher risk of subsequent development of severe sepsis (odds ratio 2.6, p < 0.01) and septic shock (odds ratio 3.7, p < 0.01). Organ system failure and mortality increased as the number of SIRS criteria increased.

Conclusions

Although common in the ICU, SIRS has prognostic importance in predicting infections, severity of disease, organ failure and outcome.

Keywords

Infections Systemic inflammatory response syndrome Sepsis Severe sepsis Septic shock Prognosis 

Notes

Acknowledgements

This research was endorsed by the European Society for Intensive Care Medicine, and supported by an unlimited grant from Abbott, Baxter, Eli Lilly, GlaxoSmithKline and NovoNordisk.

Supplementary material

134_2005_39_MOESM1_ESM.rtf (116 kb)
Electronic Supplementary Material (DOC 456kb)

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Charles L. Sprung
    • 1
    Email author
  • Yasser Sakr
    • 2
  • Jean-Louis Vincent
    • 2
  • Jean-Roger Le Gall
    • 3
  • Konrad Reinhart
    • 4
  • V. Marco Ranieri
    • 5
  • Herwig Gerlach
    • 6
  • Jonathan Fielden
    • 7
  • C. B. Groba
    • 8
  • Didier Payen
    • 9
  1. 1.Department of Anaesthesiology and Critical Care MedicineHadassah Hebrew University, Medical CenterJerusalemIsrael
  2. 2.Department of Intensive CareErasme Hospital, Free University of BrusselsBrusselsBelgium
  3. 3.Department of Intensive CareSaint-Louis HospitalParisFrance
  4. 4.Department of Anaesthesiology and Intensive CareFriedrich Schiller University JenaJenaGermany
  5. 5.Department of Anaesthesiology and Intensive CareUniversity of Turin, S. Giovanni Battista HospitalTurinItaly
  6. 6.Department of Anaesthesiology and Intensive CareVivantes-Klinikum NeukölnBerlinGermany
  7. 7.Department of Intensive CareRoyal Berkshire HospitalReadingUK
  8. 8.Department of Anaesthesiology and Intensive CareUniversity Hospital LewishamLondonUK
  9. 9.Department of Anaesthesiology and Intensive CareCentre Hospitalier Universitaire LariboisiereParisFrance

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