An evaluation of systemic inflammatory response syndrome signs in the Sepsis Occurrence in Acutely ill Patients (SOAP) study
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To define the frequency and prognostic implications of SIRS criteria in critically ill patients hospitalized in European ICUs
Design and setting
Cohort, multicentre, observational study of 198 ICUs in 24 European countries.
Patients and interventions
All 3,147 new adult admissions to participating ICUs between 1 and 15 May 2002 were included. Data were collected prospectively, with common SIRS criteria.
During the ICU stay 93% of patients had at least two SIRS criteria [respiratory rate (82%), heart rate (80%)]. The frequency of having three or four SIRS criteria vs. two was higher in infected than non-infected patients (p < 0.01). In non-infected patients having more than two SIRS criteria was associated with a higher risk of subsequent development of severe sepsis (odds ratio 2.6, p < 0.01) and septic shock (odds ratio 3.7, p < 0.01). Organ system failure and mortality increased as the number of SIRS criteria increased.
Although common in the ICU, SIRS has prognostic importance in predicting infections, severity of disease, organ failure and outcome.
KeywordsInfections Systemic inflammatory response syndrome Sepsis Severe sepsis Septic shock Prognosis
This research was endorsed by the European Society for Intensive Care Medicine, and supported by an unlimited grant from Abbott, Baxter, Eli Lilly, GlaxoSmithKline and NovoNordisk.
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