Intensive Care Medicine

, Volume 32, Issue 3, pp 349–360 | Cite as

Organ dysfunction during sepsis

Seminal Study in Intensive Care



Multiple organ dysfunction syndrome is the commonest reason for sepsis-associated mortality.


In the 40 years since it was first described understanding of its pathophysiology has improved, and novel methodologies for monitoring and severity of illness scoring have emerged. These, together with the development of systematic strategies for managing organ dysfunction in sepsis, and potentially effective new therapeutic interventions, should assist in reducing sepsis-associated mortality.


These historical developments are discussed, and the reader is directed to these references for further guidance.


Multiple organ dysfunction syndrome Sepsis Microvascular dysfunction Cytopathic hypoxia Bioenergetic failure Scoring system 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Department of Intensive Care MedicineChelsea and Westminster HospitalLondonUK
  2. 2.Department of Intensive Care Medicine, Royal Brompton HospitalImperial College School of MedicineLondonUK

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