Year in review in intensive care medicine. 2005. I. Acute respiratory failure and acute lung injury, ventilation, hemodynamics, education, renal failure
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Acute Respiratory Failure
Acute lung injury
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) have been the subjects of several important studies which address the issues of biological markers, respiratory monitoring tools to guide ventilatory settings, and risk factors for developing ARDS.
Fibroproliferation in ARDS seems to have important prognostic implications. Because fibroproliferation markers, such as procollagen I, predict mortality in patients with ALI and ARDS, Budinger et al. examined whether bronchoalveolar lavage fluid (BALF) from patients with lung injury contains mediators that would activate procollagen-I promoter, and if this activation predicts important clinical outcomes . The BALF was also collected from patients with pulmonary fibrosis and cardiogenic pulmonary edema. The BALF active TGF-beta 1 levels were measured in 29 ARDS patients, with nine negative and six positive controls being enrolled also. The BALF from ARDS patients induced 41%...
KeywordsContinuous Positive Airway Pressure Mean Arterial Pressure Acute Lung Injury Chronic Obstructive Pulmonary Disease Patient Acute Respiratory Distress Syndrome
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