Intensive Care Medicine

, Volume 31, Issue 2, pp 243–249 | Cite as

Use of the Sequential Organ Failure Assessment score as a severity score

  • André Carlos Kajdacsy-Balla Amaral
  • Fábio Moreira Andrade
  • Rui Moreno
  • Antonio Artigas
  • Francis Cantraine
  • Jean-Louis VincentEmail author



To evaluate whether the SOFA score can be used to develop a model to predict intensive care unit (ICU) mortality in different countries.

Design and setting

Analysis of a prospectively collected database. Patients with ICU stay longer than 2 days were studied to develop a mortality prediction model based on measurements of organ dysfunction.


748 patients from six countries.

Measurements and results

Two logistic regression models were constructed, one based on the SOFA maximum (SOFA Max model) and the other on variables identified by multivariate regression (SOFA Max-infection model). The H and C statistics had a p value above 0.05 for both models, but the D statistics showed a poor performance on the SOFA Max model when stratified for the presence of infection. Subsequent analysis was performed with SOFA Max-infection model. The area under the curve was 0.853. There were no statistically significant differences in observed and predicted mortalities except for one country which had a higher than predicted ICU mortality both in the overall population (28.3 vs. 19.1%) and in the noninfected patients (21.4 vs. 12.6%).


The SOFA Max adjusted for age and the presence of infection can predict mortality in this population, but in one country the ICU mortality was higher than expected. Our data do not allow us to determine the reasons behind these differences, and further studies to detect differences in mortality between countries and to elucidate the basis for these differences should be encouraged.


Infection International Outcome Organ dysfunction 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • André Carlos Kajdacsy-Balla Amaral
    • 1
  • Fábio Moreira Andrade
    • 1
  • Rui Moreno
    • 2
  • Antonio Artigas
    • 3
  • Francis Cantraine
    • 4
  • Jean-Louis Vincent
    • 1
    Email author
  1. 1.Department of Intensive Care, Erasme HospitalFree University of BrusselsBrusselsBelgium
  2. 2.Department of Intensive CareHospital de St. António dos CapuchosPortugal
  3. 3.Critical Care Center, Sabadell Hospital, Red GIRA G03/063, Parc Tauli University Institute, Department of MedicineAutonomous University of BarcelonaBarcelonaSpain
  4. 4.School of MedicineFree University of BrusselsBrusselsBelgium

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