Intensive Care Medicine

, Volume 30, Issue 11, pp 2009–2016

Research issues in the evaluation of cognitive impairment in intensive care unit survivors

  • James C. Jackson
  • Sharon M. Gordon
  • E. Wesley Ely
  • Candice Burger
  • Ramona O. Hopkins


Neuropsychological assessment has been utilized extensively in the research of cognitive outcomes associated with medical illnesses, such as HIV, and post-surgical procedures, such as coronary artery bypass graft. However, few investigations of intensive care unit (ICU) survivors have examined cognitive function as a clinical outcome. Significant clinical questions exist regarding the impact of critical illness on long-term cognitive function. Many of these questions can be systematically evaluated through the use of standardized neuropsychological assessment instruments within the context of well designed, prospective research trials. This review will provide information for clinical researchers interested in the study of neuropsychological outcomes in intensive care unit survivors ( a comparison article in this issue will address clinical issues related to cognitive functioning).


Neuropsychological outcomes Critical illness Intensive care Cognitive impairment 

Supplementary material

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • James C. Jackson
    • 1
    • 2
    • 4
  • Sharon M. Gordon
    • 2
    • 3
    • 4
  • E. Wesley Ely
    • 1
    • 2
    • 3
  • Candice Burger
    • 4
  • Ramona O. Hopkins
    • 5
    • 6
  1. 1.Division of Allergy, Pulmonary and Critical Care Medicine, T-1218 Medical Center NorthVanderbilt University School of MedicineNashvilleUSA
  2. 2.Medical Center East Suite 6100Center for Health Services ResearchNashvilleUSA
  3. 3.Geriatric Research Education and Clinical Center of the Veterans Administration Tennessee Valley Healthcare SystemNashvilleUSA
  4. 4.Department of PsychiatryVanderbilt University School of MedicineNashvilleUSA
  5. 5.Psychology Department and Neuroscience CenterBrigham Young UniversityProvoUSA
  6. 6.Department of Medicine, Pulmonary and Critical Care DivisionsLDS HospitalSalt Lake CityUSA

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