Intensive Care Medicine

, Volume 30, Issue 10, pp 1886–1890 | Cite as

Acute renal failure is not a “cute” renal failure!

Clinical Commentary


  1. 1.
    Levy EM, Viscoli CM, Horwitz RI (1996) The effect of acute renal failure on mortality. A cohort analysis. JAMA 275:1489–1494PubMedGoogle Scholar
  2. 2.
    Chertow GM, Levy EM, Hammermeister KE, Grover F, Daley J (1998) Independent association between acute renal failure and mortality following cardiac surgery. Am J Med 104:343–348PubMedGoogle Scholar
  3. 3.
    Metnitz PG, Krenn CG, Steltzer H, Lang T, Ploder J, Lenz K, Le Gall JR, Druml W (2002) Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Crit Care Med 30:2051–2058Google Scholar
  4. 4.
    Kellum JA, Angus DC (2002) Patients are dying of acute renal failure. Crit Care Med 30:2156–2157CrossRefPubMedGoogle Scholar
  5. 5.
    Rabb H, Daniels F, O’Donnell M, Haq M, Saba SR, Keane W, Tang WW (2000) Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice. Am J Physiol Renal Physiol 279:F525–531PubMedGoogle Scholar
  6. 6.
    Kramer AA, Postler G, Salhab KF, Mendez C, Carey LC, Rabb H (1999) Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. Kidney Int 55:2362–2367CrossRefPubMedGoogle Scholar
  7. 7.
    Yokota N, Daniels F, Crosson J, Rabb H (2002) Protective effect of T cell depletion in murine renal ischemia-reperfusion injury. Transplantation 74:759–763CrossRefPubMedGoogle Scholar
  8. 8.
    Harper SJ, Tomson CR, Bates DO (2002) Human uremic plasma increases microvascular permeability to water and proteins in vivo. Kidney Int 61:1416–1422CrossRefPubMedGoogle Scholar
  9. 9.
    Kelly KJ (2003) Distant effects of experimental renal ischemia/reperfusion injury. J Am Soc Nephrol 14:1549–1558PubMedGoogle Scholar
  10. 10.
    Meldrum KK, Meldrum DR, Meng X, Ao L, Harken AH (2002) TNF-alpha-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion. Am J Physiol Heart Circ Physiol 282:H540–546PubMedGoogle Scholar
  11. 11.
    Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards V, Cutz E, Liu M, Keshavjee S, Martin TR, Marshall JC, Ranieri VM, Slutsky AS (2003) Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 289:2104–2112CrossRefPubMedGoogle Scholar
  12. 12.
    Suter PM (2002) MV causes lung inflammation and systemic immune depression. A balance of fire and ice. Intensive Care Med 28:383–385PubMedGoogle Scholar
  13. 13.
    Gormley SM, McBride WT, Armstrong MA, McClean E, MacGowan SW, Campalani G, McMurray TJ (2002) Plasma and urinary cytokine homeostasis and renal function during cardiac surgery without cardiopulmonary bypass. Cytokine 17:61–65CrossRefPubMedGoogle Scholar
  14. 14.
    Haag-Weber M, Horl WH (1996) Dysfunction of polymorphonuclear leukocytes in uremia. Semin Nephrol 16:192–201PubMedGoogle Scholar
  15. 15.
    Cohen G, Haag-Weber M, Horl WH (1997) Immune dysfunction in uremia. Kidney Int Suppl 62:S79–82PubMedGoogle Scholar
  16. 16.
    Druml W (2001) Nutritional management of acute renal failure. Am J Kidney Dis 37:S89–94PubMedGoogle Scholar
  17. 17.
    Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P (2003) Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 31:359–366PubMedGoogle Scholar
  18. 18.
    Woodrow G, Turney JH (1992) Cause of death in acute renal failure. Nephrol Dial Transplant 7:230–234PubMedGoogle Scholar
  19. 19.
    Cook D, Heyland D, Griffith L, Cook R, Marshall J, Pagliarello J (1999) Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Crit Care Med 27:2812–2817Google Scholar
  20. 20.
    Fiaccadori E, Maggiore U, Clima B, Melfa L, Rotelli C, Borghetti A (2001) Incidence, risk factors and prognosis of gastrointestinal hemorrhage complicating acute renal failure. Kidney Int 59:1510–1519CrossRefPubMedGoogle Scholar
  21. 21.
    Druml W (1999) Metabolic aspects of continuous renal replacement therapies. Kidney Int Suppl 72:S56–61PubMedGoogle Scholar
  22. 22.
    Metnitz GH, Fischer M, Bartens C, Steltzer H, Lang T, Druml W (2000) Impact of acute renal failure on antioxidant status in multiple organ failure. Acta Anaesthesiol Scand 44:236–240CrossRefPubMedGoogle Scholar
  23. 23.
    Vogt B, Ferrari P, Schonholzer C, Marti HP, Mohaupt M, Wiederkehr M, Cereghetti C, Serra A, Huynh-Do U, Uehlinger D, Frey FJ (2001) Prophylactic hemodialysis after radiocontrast media in patients with renal insufficiency is potentially harmful. Am J Med 111:692–698PubMedGoogle Scholar
  24. 24.
    Fissell WH, Lou L, Abrishami S, Buffington DA, Humes HD (2003) Bioartificial kidney ameliorates gram-negative bacteria-induced septic shock in uremic animals. J Am Soc Nephrol 14:454–461PubMedGoogle Scholar
  25. 25.
    Gettings LG, Reynolds HN, Scalea T (1999) Outcome in post-traumatic acute renal failure when continuous renal replacement therapy is applied early vs. late. Intensive Care Med 25:805–813PubMedGoogle Scholar
  26. 26.
    Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P, La Greca G (2000) Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 356:26–30PubMedGoogle Scholar
  27. 27.
    Bouman CS, Oudemans-Van Straaten HM, Tijssen JG, Zandstra DF, Kesecioglu J (2002) Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: a prospective, randomized trial. Crit Care Med 30:2205–2211CrossRefPubMedGoogle Scholar
  28. 28.
    Evanson JA, Ikizler TA, Wingard R, Knights S, Shyr Y, Schulman G, Himmelfarb J, Hakim RM (1999) Measurement of the delivery of dialysis in acute renal failure. Kidney Int 55:1501–1508CrossRefPubMedGoogle Scholar
  29. 29.
    Schiffl H, Lang SM, Fischer R (2002) Daily hemodialysis and the outcome of acute renal failure. N Engl J Med 346:305–310Google Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Department of Medicine III, Division of NephrologyVienna General HospitalViennaAustria

Personalised recommendations