The importance of magnesium in critically ill patients: a role in mitigating neurological injury and in the prevention of vasospasms
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Sir: We read with great interest the review on magnesium metabolism in critical illness by Noronha and Matuschak, which appeared in the June issue of Intensive Care Medicine . We compliment the authors on their outstanding work, and hope that their review will contribute to an increased awareness of the importance of magnesium in critically ill patients. We would, however, like to make a number of additions to their otherwise thorough and comprehensive paper.
First, although Noronha and Matuschak briefly mention the possible neurological manifestations of hypomagnesaemia, they do not discuss the potentially important role of magnesium (Mg) in patients with various types of neurological injury. There is a large body of evidence (mainly from animal experiments) suggesting that Mg plays a key role in preventing additional brain damage following neurological injury [2, 3, 4, 5]. In experimentally induced brain injury, Mg depletion leads to significantly worse neurological outcome [2, 3]...
KeywordsTherapeutic Hypothermia Neurological Injury Brain Damage Intensive Care Medicine Severe Head Injury
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