Intensive Care Medicine

, Volume 29, Issue 5, pp 669–671 | Cite as

Does immunonutrition in patients with sepsis do more harm than good?



  1. 1.
    Heyland DK, Novak F, Drover J, Jain M, Suchner U (2001) Should immunonutrition become routine in critically ill patients: a systematic review of the evidence. JAMA 286:944–953PubMedGoogle Scholar
  2. 2.
    Bower RH, Cerra FB, Bershadsky B, Licari JJ, Hoyt DB, Jensen GL, et al (1995) Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Crit Care Med 23:436–449Google Scholar
  3. 3.
    Dent DL, Heyland DK, Levy H, Martindale R, Tayek J, Schloerb P, Kelley MJ (2003) Immunonutrition may increase mortality in critically ill patients with pneumonia: results of a randomized trial. Crit Care Med 30:A17Google Scholar
  4. 4.
    Galban C, Montejo JC, Mesejo A, et al (2000) An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients. Crit Care Med 28:643–648PubMedGoogle Scholar
  5. 5.
    Heyland DK, MacDonald S, Keefe L, Drover JW (1998) Total parenteral nutrition in the critically ill patient: a meta-analysis. JAMA 280:2013–2019CrossRefPubMedGoogle Scholar
  6. 6.
    Basttistella FD, Widergren JT, Anderson JT, et al (1997) A prospective, randomized trial of intravenous fat emulsion administration in trauma victims requiring total parenteral nutrition. J Trauma 43:52–58PubMedGoogle Scholar
  7. 7.
    Bruins MJ, Soeters PB, Larners WH, Meijer AJ, Deutz NEP (2002) L-Arginine supplementation in hyperdynamic endotoxemic pigs: effect on nitric oxide synthesis by different organs. Crit Care Med 30:508–517PubMedGoogle Scholar
  8. 8.
    Suchner U, Heyland DK, Peter K (2002) Immune-modulating actions of arginine in the critically ill. Br J Nutr 87[Suppl 1]:S121–132Google Scholar
  9. 9.
    Heyland DK (2002) Immunonutrition in the critically ill patient: putting the cart before the horse? Nutr Clin Pract17:267–272Google Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Kingston General HospitalKingstonCanada
  2. 2.Queen's UniversityKingston Canada

Personalised recommendations