Long-term health-related quality of life in survivors of severe acute pancreatitis
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To evaluate the health-related quality of life (HRQL) and postdischarge outcome after severe acute pancreatitis.
Design and setting
Observational study in a department of surgery (surgical and general intensive care unit) in a tertiary care hospital.
Patients and participants
Of 283 patients with severe acute pancreatitis 211 survived; during a follow-up period an additional 27 died. The Rand 36-item Health Survey with accessory question was mailed to 174 eligible patients. The final study population comprised 145 patients (83% response rate). Age- and sex-matched Finnish population scores were compared with the study population; accessory questions were analyzed separately.
No clinically significant differences were found in long-term HRQL between study patients and the general population. Of the 145 patients 87% returned to work, 27% suffered recurrent pancreatitis, and 43% developed diabetes. Of 113 patients with alcohol-induced severe acute pancreatitis 30% were abstinent and 28% problem drinkers, alcohol-dependent, or alcoholics.
Up to 13% of severe acute pancreatitis patients surviving initial hospitalization die within a few years. Among the survivors long-term HRQL is comparable to that of the normal population. The majority return to work and reduce their alcohol consumption markedly.
KeywordsSevereacute pancreatitis Quality of life Outcome
- 3.Orlando R III (2000) Quality of life in intensive care unit survivors: a place for outcomes research in critical care. Crit Care Med 28:3755–3756Google Scholar
- 9.Essink-Bot ML, Krabbe PF, Bonsel GJ, Aaronson NK (1997) An empirical comparison of four generic health status measures. The Nottingham Health Profile, the Medical Outcomes Study 36-item Short-Form Health Survey, the COOP/WONCA charts, and the EuroQol instrument. Med Care 35:522–537CrossRefPubMedGoogle Scholar
- 10.Heyland DK, Hopman W, Coo H, Tranmer J, McColl MA (2000) Long-term health-related quality of life in survivors of sepsis. Short Form 36: a valid and reliable measure of health-related quality of life. Crit Care Med 28:3599–3605Google Scholar
- 13.Bradley EL (1992) A clinically based classification system for acute pancreatitis. Summary of the international symposium on acute pancreatitis, Atlanta, GA, September 11 through 13, 1992. Arch Surg 128:586–590Google Scholar
- 14.Aalto A, Aro S, Aro AR, Mähönen M (1999) Rand 36-item survey 1.0. Finnish version. National Research and Development Centre for Welfare and Health, HelsinkiGoogle Scholar
- 16.Anonymous (2002) Rand-36 item health survey 1.0. Rand Health Program. http://www.rand.org/health/surveys/sf36item/, 3 JanGoogle Scholar
- 17.Vincent JL. de Mendonca A. Cantraine F. Moreno R. Takala J. Suter PM. Sprung CL. Colardyn F. Blecher S (1998) Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med 26:1793–1800PubMedGoogle Scholar
- 18.Weinert GR, Gross CR, Kangas JR, Bury CL, Marinelli WA (1997) Health-related quality of life after acute lung injury. Am J Respir Crit Care Med 156:1120–1128Google Scholar
- 21.Schröder T, Puolakkainen P, Rämö J, Nuutinen P, Kivilaakso E, Kiviluoto T, Haapsaari P, Kivisaari L (1990) Long term results after pancreatic resection and peritoneal lavage for acute hemorrhagic pancreatitis. Surg Res Commun 7:145–149Google Scholar
- 22.Büchler M, Hauke A, Malfertheiner P (1987) Follow-up after acute pancreatitis—morphology and function. In: Beger HG, Büchler M (ed) Acute pancreatitis—research and clinical management. Springer, Berlin Heidelberg New York, pp 367–374Google Scholar