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Intensive Care Medicine

, Volume 29, Issue 4, pp 655–658 | Cite as

Nasal carriage of Staphylococcus aureus on admission to intensive care: incidence and prognostic significance

  • Richard Porter
  • Kandasamy Subramani
  • Antony N. ThomasEmail author
  • Paul Chadwick
Brief Report

Abstract

We retrospectively studied the prevalence of the nasal carriage of methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) on admission to a medical surgical intensive care unit (ICU). We also compared the intensive care survival of MSSA carriers with non-carriers. Records of 678 patients admitted over a 24-month period were retrospectively reviewed. Nasal swabs were taken from 565 patients on admission to the ICU. MSSA was isolated from the anterior nares of 126 (22%) patients, MRSA was isolated in 16 (3%) patients and 423 (75%) patients had no nasal carriage identified. MSSA carriers were more likely to have been admitted to the ICU after less than 24 h hospital stay (28% non-carriers, 44% MSSA carriers) and were significantly younger (mean age of 50 years) than non-carriers (mean age 55 years). The median survival (with confidence intervals (CI)) was 29 days (CI 14–44) in non-carriers, 16 days (CI 10–22) in MSSA carriers and 6 days (CI 4–8) for the MRSA carriers. This difference was significant when MSSA carriers were compared with non-carriers (p=0.003). The ICU mortality was also significantly higher (p=0.004) in MSSA carriers (88 of the 423 (21%) non-carriers and 40 of 126 (32%) MSSA carriers died prior to ICU discharge).

Keywords

Methicillin-sensitive Staphylococcus aureus (MSSA) Methicillin-resistant Staphylococcus aureus (MRSA) Nasal carriage Intensive care unit (ICU) mortality Nosocomial infection 

Notes

Acknowledgement

We would like to thank Dr. Andrew Vail for statistical advice.

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Richard Porter
    • 1
  • Kandasamy Subramani
    • 1
  • Antony N. Thomas
    • 1
    Email author
  • Paul Chadwick
    • 2
  1. 1.Department of Intensive Care MedicineHope HospitalSalfordUnited Kingdom
  2. 2.Department of MicrobiologyHope HospitalSalfordUnited Kingdom

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