Intensive Care Medicine

, Volume 28, Issue 9, pp 1220–1225 | Cite as

Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis

  • Ville Pettilä
  • Marja Hynninen
  • Olli Takkunen
  • Pentti Kuusela
  • Matti Valtonen
Original

Abstract

Objective. To evaluate the performance of procalcitonin (PCT), interleukin-6 (IL-6), C-reactive protein, leukocyte count, D-dimer, and antithrombin III at onset of septic episode and 24 h later in prediction of hospital mortality in critically ill patients with suspected sepsis.

Design and setting. Prospective, cohort study in two university hospital intensive care units.

Patients. 61 critically ill patients with suspected sepsis.

Measurements and results. The outcome measure was hospital mortality. Hospital survivors (n=41) and nonsurvivors (n=20) differed statistically significantly on day 1 (admission) in PCT, IL-6, SOFA score, and APACHE II score, and 24 h later in PCT, IL-6, and D-dimer values. AT III, CRP, and leukocyte count did not differ. The areas under receiver operating curves showed reasonable discriminative power (>0.75) in predicting hospital mortality only for day 2 IL-6 (0.799) and day 2 PCT (0.777) values which were comparable to that of APACHE II (0.786), and which remained the only independent predictor of mortality.

Conclusions. Admission and day 2 IL-6, and day 2 PCT, and day 2 D-dimer values differed significantly between hospital survivors and nonsurvivors among critically ill patients with suspected sepsis. However, in prediction of hospital mortality, only the discriminative power of day 2 PCT and IL-6 values, and APACHE II was reasonable as judged by AUC analysis (>0.75).

Prediction Outcome Cytokines Intensive care Sepsis Procalcitonin 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Ville Pettilä
    • 1
  • Marja Hynninen
    • 1
  • Olli Takkunen
    • 1
  • Pentti Kuusela
    • 2
  • Matti Valtonen
    • 3
  1. 1.Intensive Care Unit, Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P.O. Box 340, 00029/HUS, HelsinkiFinland
  2. 2.Department of Diagnostics, Helsinki University Hospital, P.O. Box 340, 00029/HUS, HelsinkiFinland
  3. 3.Division of Infectious Diseases, Department of Internal Medicine, Helsinki University Hospital, P.O. Box 340, 00029/HUS, HelsinkiFinland

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