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Tumorinduzierte Osteomalazie, verursacht durch ein FGF23-sezernierendes Myoperizytom

Literaturübersicht und Fallbericht
  • N. Muro BushartEmail author
  • L. Tharun
  • R. Oheim
  • A. Paech
  • J. Kiene
Übersichten

Zusammenfassung

Hintergrund

Die Symptome Muskelschwäche, Knochenschmerzen und Insuffizienzfrakturen können ein Hinweis auf eine Osteomalazie sein. Phosphat wird als osteologischer Parameter häufig nicht berücksichtigt und erniedrigte Werte daher übersehen. Die zusätzliche Untersuchung von FGF23 („fibroblast growth factor“ 23) als Nachweis eines osteomalazieinduzierenden Tumors ist noch überwiegend unbekannt.

Ziele der Arbeit

Die Schlüsselrolle von Phosphat und darüber hinaus von FGF23 im Knochenstoffwechsel soll durch den langjährigen Verlauf unseres klinischen Falls veranschaulicht und einem breiteren Publikum vorgestellt werden.

Methoden

Wir führten eine Literaturrecherche via PubMed und Google Scholar mit den relevanten Schlüsselwörtern durch und fassten die diagnostischen und therapeutischen Informationen zusammen. Die untersuchten Studien waren überwiegend Einzelfallberichte. Wir erstellten einen Fallbericht einer 70-jährigen Patientin mit tumorinduzierter Osteomalazie (TIO) durch ein Myoperizytom und untersuchten retrospektiv den klinischen Fall. Das Follow-up betrug 6 Monate.

Ergebnis

Die Literaturrecherche ergab unter 124 Fällen von Myoperizytomen einen mit TIO und Nachweis von FGF23. Es sind über 300 Fälle von TIO dokumentiert. Bei unserem klinischen Fall fanden wir retrospektiv ein FGF23-sezernierendes Myoperizytom aus der Gruppe der phosphaturischen mesenchymalen Tumoren (PMT) als Ursache einer Humerusschaftpseudarthose rechts und zunehmender Bewegungseinschränkung bei einer Patientin mit unerkannter TIO. Nach chirurgischer Resektion des Tumors wurde die Patientin wieder mobil, die osteologischen Parameter, insbesondere des Phosphats, normalisierten sich von 0,21 auf 1,52 mmol/l.

Schlussfolgerung

Erniedrigte Phosphatwerte sind in unserem Fall der entscheidende Hinweis auf eine TIO. Im Umkehrschluss sollte bei einer Osteomalazie immer an eine Phosphatkontrolle gedacht werden. Eine Hypophosphatämie und Hyperphosphaturie sollten frühzeitig erkannt und diagnostisch abgeklärt werden. Die Untersuchung von FGF23 (C-terminales Fragment und intaktes FGF23) ist zu erwägen.

Schlüsselwörter

Knochenerweichung Fibroblast growth factor 23, human Hypophosphatämie Neoplasie Phosphat 

Abkürzungen

ADHR

Autosomal-dominante hypophosphatämische Rachitis

cFGF23

c-terminales Fragment

CT

Computertomographie

DOTATATE

Dota-[Tyr3]-Octreotat

DVO

Dachverband Osteologie

DXA

Dual-Röntgen-Absorptiometrie

ELISA

„Enzyme-linked immunosorbent assay“

ERG

„Ets related gene“

FDG

Fluordesoxyglukose

FGF23

„Fibroblast growth factor 23“

FGFR1

„Fibroblast growth factor receptor 1“

iFGF23

Intaktes FGF23

ISH

In-situ-Hybridisierung

Ki67-Färbung

Immunhistologischer Marker

MRT

Magnetresonanztomographie

PET

Positronenemissionstomographie

PMT

Phosphaturischer mesenchymaler Tumor

PTH

Parathormon

RNA

Ribonukleinsäure

RT-PCR

Reverse-Transkriptase-Polymerase-Kettenreaktion

SATB2

„Special AT-rich sequence-binding protein 2“

SPECT

„Single photon emission computed tomography“

TIO

Tumorinduzierte Osteomalazie

Tumor-induced osteomalacia caused by an FGF23-secreting myopericytoma

Case report and literature review

Abstract

Background

The symptoms of muscle weakness, bone pain and fragility fractures can be an indication of osteomalacia. Phosphate is often not considered within osteologic parameters, decreased levels are therefore easily overseen. The additional test for fibroblast growth factor 23 (FGF23) as indicator for tumor-induced osteomalacia (TIO) is still largely unfamiliar.

Objective

By emphasizing the role of phosphate and furthermore FGF23 in bone metabolism illustrated by the long-term disease process of our clinical case we would like to introduce these parameters to a broader public.

Methods

We performed a literature search via PubMed and Google Scholar with the relevant key words and summarized the diagnostic and therapeutic information. The studies evaluated were mainly case reports. We present a case report of a 70-year-old patient with TIO and a myopericytoma and retrospectively analyzed the clinical case. The follow-up was 6 months.

Results

Our literature search found one case of TIO and evidence of FGF23 among 124 cases of myopericytomas in total. Over 300 cases of TIO are reported. In our case, we retrospectively found an FGF23-secreting myopericytoma in the phosphaturic mesenchymal tumors (PMT) group to be the cause of pseudarthrosis on the right humerus shaft and increasing disablement in a patient with osteomalacia. After surgical resection the patient was mobile again, and the osteologic parameters, especially phosphate, normalized from 0.21 to 1.52 mmol/l.

Conclusion

Low phosphate levels are the decisive indication of TIO in our case. Therefore, we should always think of phosphate level control when dealing with osteomalacia. A hypophosphatemia and hyperphosphaturia should be recognized in time and be diagnostically verified. The additional FGF23 test (c-terminal and intact FGF23) should be considered.

Keywords

Adult rickets  Fibroblast growth factor 23, human Hypophosphatemia Neoplasia Phosphate 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

N. Muro Bushart, L. Tharun, R. Oheim, A. Paech und J. Kiene geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Supplementary material

132_2019_3719_MOESM1_ESM.pdf (58 kb)
Fälle onkogener Osteomalazie ab 1990 und Fälle von Myoperizytomen: NA not available, DOD deceased of disease [17, 18, 19, 22, 25, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111].

Literatur

  1. 1.
    Berndt T, Kumar R (2009) Novel mechanisms in the regulation of phosphorus homeostasis. Comp Biochem Physiol A Physiol 24:17–25.  https://doi.org/10.1152/physiol.00034.2008 CrossRefGoogle Scholar
  2. 2.
    Minisola S, Peacock M, Fukumoto S, Cipriani C, Pepe J, Tella SH, Collins MT (2017) Tumour-induced osteomalacia. Nat Rev Dis Primers 3:17044.  https://doi.org/10.1038/nrdp.2017.44 CrossRefPubMedGoogle Scholar
  3. 3.
    Bartl R (Hrsg) (2014) Klinische Osteologie. Entstehung, Diagnostik, Prävention und Therapie aller Knochenerkrankungen. Thieme, Stuttgart, New York, Delhi, RioCrossRefGoogle Scholar
  4. 4.
    Kuro-o M (2010) Overview of the FGF23-Klotho axis. Pediatr Nephrol 25(4):583–590.  https://doi.org/10.1007/s00467-009-1260-4 CrossRefPubMedGoogle Scholar
  5. 5.
    Goetz R, Nakada Y, Hu MC, Kurosu H, Wang L, Nakatani T, Shi M, Eliseenkova AV, Razzaque MS, Moe OW, Kuro-o M, Mohammadi M (2010) Isolated C‑terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. Proc Natl Acad Sci USA 107(1):407–412.  https://doi.org/10.1073/pnas.0902006107 CrossRefPubMedGoogle Scholar
  6. 6.
    Blum H (2018) Klinische Pathophysiologie. Thieme, Stuttgart, New York, Delhi, RioCrossRefGoogle Scholar
  7. 7.
    Suttorp N (2017) Harrisons Innere Medizin. Thieme, Stuttgart, New York, Delhi, RioGoogle Scholar
  8. 8.
    Chanchal R, Gupta S, Kanta C, Singh K, Koonwar S (2018) Hypophosphataemia in severe acute malnutrition: a prospective observational study. Br J Nutr.  https://doi.org/10.1017/s0007114518003197 CrossRefPubMedGoogle Scholar
  9. 9.
    Wolf M, Chertow GM, Macdougall IC, Kaper R, Krop J, Strauss W (2018) Randomized trial of intravenous iron-induced hypophosphatemia. JCI Insight.  https://doi.org/10.1172/jci.insight.124486 CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Wolf M, Koch TA, Bregman DB (2013) Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women. J Bone Miner Res 28(8):1793–1803.  https://doi.org/10.1002/jbmr.1923 CrossRefPubMedGoogle Scholar
  11. 11.
    David V, Francis C, Babitt JL (2017) Ironing out the cross talk between FGF23 and inflammation. Am J Physiol Renal Physiol 312(1):F1–F8.  https://doi.org/10.1152/ajprenal.00359.2016 CrossRefPubMedGoogle Scholar
  12. 12.
    Perwad F, Zhang MY, Tenenhouse HS, Portale AA (2007) Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D‑1alpha-hydroxylase expression in vitro. Am J Physiol Renal Physiol 293(5):F1577–F1583.  https://doi.org/10.1152/ajprenal.00463.2006 CrossRefPubMedGoogle Scholar
  13. 13.
    Shimada T, Mizutani S, Muto T, Yoneya T, Hino R, Takeda S, Takeuchi Y, Fujita T, Fukumoto S, Yamashita T (2001) Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci USA 98(11):6500–6505.  https://doi.org/10.1073/pnas.101545198 CrossRefPubMedGoogle Scholar
  14. 14.
    Hautmann AH, Hautmann MG, Kolbl O, Herr W, Fleck M (2015) Tumor-induced osteomalacia: an up-to-date review. Curr Rheumatol Rep 17(6):512.  https://doi.org/10.1007/s11926-015-0512-5 CrossRefPubMedGoogle Scholar
  15. 15.
    DGKED e.V. (2016) S1 Leitlinie Hereditäre hypophosphatämische Rachitiden. https://www.awmf.org/uploads/tx_szleitlinien/174-008l_S1_Hereditaere_hypophosphataemische_Rachitiden_2016-05.pdf. Zugegriffen: 25.01.2019Google Scholar
  16. 16.
    Lee JC, Jeng YM, Su SY, Wu CT, Tsai KS, Lee CH, Lin CY, Carter JM, Huang JW, Chen SH, Shih SR, Marino-Enriquez A, Chen CC, Folpe AL, Chang YL, Liang CW (2015) Identification of a novel FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour. J Pathol 235(4):539–545.  https://doi.org/10.1002/path.4465 CrossRefPubMedGoogle Scholar
  17. 17.
    Folpe AL, Fanburg-Smith JC, Billings SD, Bisceglia M, Bertoni F, Cho JY, Econs MJ, Inwards CY, de Beur JSM, Mentzel T, Montgomery E, Michal M, Miettinen M, Mills SE, Reith JD, O’Connell JX, Rosenberg AE, Rubin BP, Sweet DE, Vinh TN, Wold LE, Wehrli BM, White KE, Zaino RJ, Weiss SW (2004) Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol 28(1):1–30CrossRefPubMedGoogle Scholar
  18. 18.
    McCance R (1947) Osteomalacia with Looser’s nodes (Milkman’s syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years. Q J Med 16(1):33–46PubMedGoogle Scholar
  19. 19.
    Wilkins GE, Granleese S, Hegele RG, Holden J, Anderson DW, Bondy GP (1995) Oncogenic osteomalacia: evidence for a humoral phosphaturic factor. J Clin Endocrinol Metab 80(5):1628–1634.  https://doi.org/10.1210/jcem.80.5.7745010 CrossRefPubMedGoogle Scholar
  20. 20.
    Chong WH, Molinolo AA, Chen CC, Collins MT (2011) Tumor-induced osteomalacia. Endocr Relat Cancer 18(3):R53–R77.  https://doi.org/10.1530/erc-11-0006 CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Fletcher CDM, Krishnan K, Mertens UF (2002) Pathology and genetics of tumours of soft tissue and boneGoogle Scholar
  22. 22.
    Brunschweiler B, Guedj N, Lenoir T, Faillot T, Rillardon L, Guigui P (2009) Oncogenous osteomalacia and myopericytoma of the thoracic spine: a case report. Spine 34(23):E857–E860.  https://doi.org/10.1097/BRS.0b013e3181b780e9 CrossRefPubMedGoogle Scholar
  23. 23.
    Huang X, Jiang Y, Xia W (2013) FGF23 and phosphate wasting disorders. Bone Res 1(2):120–132.  https://doi.org/10.4248/br201302002 CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    El-Maouche D, Dumitrescu CE, Andreopoulou P, Gafni RI, Brillante BA, Bhattacharyya N, Fedarko NS, Collins MT (2016) Stability and degradation of fibroblast growth factor 23 (FGF23): the effect of time and temperature and assay type. Osteoporos Int 27(7):2345–2353.  https://doi.org/10.1007/s00198-016-3543-5 CrossRefPubMedGoogle Scholar
  25. 25.
    Carter JM, Caron BL, Dogan A, Folpe AL (2015) A novel chromogenic in situ hybridization assay for FGF23 mRNA in phosphaturic mesenchymal tumors. Am J Surg Pathol 39(1):75–83.  https://doi.org/10.1097/pas.0000000000000290 CrossRefPubMedGoogle Scholar
  26. 26.
    Bitzan M, Goodyer PR (2019) Hypophosphatemic Rickets. Pediatr Clin North Am 66(1):179–207.  https://doi.org/10.1016/j.pcl.2018.09.004 CrossRefPubMedGoogle Scholar
  27. 27.
    Kinoshita Y, Fukumoto S (2018) X‑linked Hypophosphatemia and FGF23-related Hypophosphatemic diseases: prospect for new treatment. Endocr Rev 39(3):274–291.  https://doi.org/10.1210/er.2017-00220 CrossRefPubMedGoogle Scholar
  28. 28.
    Graham R, Krishnamurthy S, Oliveira A, Inwards C, Folpe AL (2012) Frequent expression of fibroblast growth factor-23 (FGF23) mRNA in aneurysmal bone cysts and chondromyxoid fibromas. J Clin Pathol 65(10):907–909.  https://doi.org/10.1136/jclinpath-2012-200852 CrossRefPubMedGoogle Scholar
  29. 29.
    Houang M, Clarkson A, Sioson L, Elston MS, Clifton-Bligh RJ, Dray M, Ranchere-Vince D, Decouvelaere AV, de la Fouchardiere A, Gill AJ (2013) Phosphaturic mesenchymal tumors show positive staining for somatostatin receptor 2A (SSTR2A). Hum Pathol 44(12):2711–2718.  https://doi.org/10.1016/j.humpath.2013.07.016 CrossRefPubMedGoogle Scholar
  30. 30.
    Cox DP, Giltman L (2003) Myopericytoma of the thoracic spine: a case report. Spine (phila Pa 28(2):E30–E32.  https://doi.org/10.1097/01.brs.0000041592.79222.71 CrossRefGoogle Scholar
  31. 31.
    Ko JY, Choi WJ, Kang HS, Yu HJ, Park MH (2011) Intravascular myopericytoma: an interesting case of a long-standing large, painful subcutaneous tumor. Pathol Int 61(3):161–164.  https://doi.org/10.1111/j.1440-1827.2010.02628.x CrossRefPubMedGoogle Scholar
  32. 32.
    Lau SK, Klein R, Jiang Z, Weiss LM, Chu PG (2010) Myopericytoma of the kidney. Hum Pathol 41(10):1500–1504.  https://doi.org/10.1016/j.humpath.2010.02.014 CrossRefPubMedGoogle Scholar
  33. 33.
    Mainville GN, Satoskar AA, Iwenofu OH (2015) Primary malignant myopericytoma of the left atrium—a tumor of aggressive biological behavior: report of the first case and review of literature. Appl Immunohistochem Mol Morphol 23(6):464–469.  https://doi.org/10.1097/PAI.0b013e3182598554 CrossRefPubMedGoogle Scholar
  34. 34.
    Matsuyama A, Hisaoka M, Hashimoto H (2007) Angioleiomyoma: a clinicopathologic and immunohistochemical reappraisal with special reference to the correlation with myopericytoma. Hum Pathol 38(4):645–651.  https://doi.org/10.1016/j.humpath.2006.10.012 CrossRefPubMedGoogle Scholar
  35. 35.
    McMenamin ME, Fletcher CD (2002) Malignant myopericytoma: expanding the spectrum of tumours with myopericytic differentiation. Histopathology 41(5):450–460CrossRefPubMedGoogle Scholar
  36. 36.
    Mentzel T, Dei Tos AP, Sapi Z, Kutzner H (2006) Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol 30(1):104–113CrossRefPubMedGoogle Scholar
  37. 37.
    Mok Y, Lee JC, Lum JH, Petersson F (2016) From epistaxis to bone pain-report of two cases illustrating the clinicopathological spectrum of phosphaturic mesenchymal tumour with fibroblast growth factor receptor 1 immunohistochemical and cytogenetic analyses. Histopathology 68(6):925–930.  https://doi.org/10.1111/his.12872 CrossRefPubMedGoogle Scholar
  38. 38.
    Paek JO, Kang HS, Yeo KY, Yu HJ, Kim JS (2011) A case of myopericytoma on the lower leg. Ann Dermatol 23(2):201–204.  https://doi.org/10.5021/ad.2011.23.2.201 CrossRefPubMedPubMedCentralGoogle Scholar
  39. 39.
    Ramdial PK, Sing Y, Deonarain J, Singh B, Allopi L, Moodley P (2011) Periampullary Epstein-Barr virus-associated myopericytoma. Hum Pathol 42(9):1348–1354.  https://doi.org/10.1016/j.humpath.2010.12.001 CrossRefPubMedGoogle Scholar
  40. 40.
    Ryan EA, Reiss E (1984) Oncogenous osteomalacia. Review of the world literature of 42 cases and report of two new cases. Am J Med 77(3):501–512CrossRefPubMedGoogle Scholar
  41. 41.
    Wasserman JK, Purgina B, Lai CK, Gravel D, Mahaffey A, Bell D, Chiosea SI (2016) Phosphaturic mesenchymal tumor involving the head and neck: a report of five cases with FGFR1 fluorescence in situ hybridization analysis. Head Neck Pathol 10(3):279–285.  https://doi.org/10.1007/s12105-015-0678-1 CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Yang G, McGlinn EP, Chung KC (2015) Myopericytoma of the distal forearm: a case report. Hand 10(2):338–341.  https://doi.org/10.1007/s11552-014-9647-5 CrossRefPubMedGoogle Scholar
  43. 43.
    Zhao M, Williamson SR, Sun K, Zhu Y, Li C, Xia W, Qi H, Wang L, Linos K, Cheng L (2014) Benign perivascular myoid cell tumor (myopericytoma) of the urinary tract: a report of 2 cases with an emphasis on differential diagnosis. Hum Pathol 45(5):1115–1121.  https://doi.org/10.1016/j.humpath.2013.12.017 CrossRefPubMedGoogle Scholar
  44. 44.
    Agrawal N, Nag K (2013) Myopericytoma of the thoracic spine: a case report and review of literature. Spine J 13(11):e23–e27.  https://doi.org/10.1016/j.spinee.2013.06.050 CrossRefPubMedGoogle Scholar
  45. 45.
    Agusti J, Penas L, Bosch N (2016) Intravascular myopericytoma of the plantar region: case report and discussion of the probable origin from a cutaneous vascular malformation. Am J Dermatopathol 38(7):546–548.  https://doi.org/10.1097/dad.0000000000000522 CrossRefPubMedGoogle Scholar
  46. 46.
    Aung PP, Goldberg LJ, Mahalingam M, Bhawan J (2015) Cutaneous Myopericytoma: a report of 3 cases and review of the literature. Dermatopathology 2(1):9–14.  https://doi.org/10.1159/000371875 CrossRefPubMedPubMedCentralGoogle Scholar
  47. 47.
    Chaskes MB, Bishop JW, Bobinski M, Farwell DG (2017) Myopericytoma of the neck originating in the middle scalene muscle: a case report. Ear Nose Throat J 96(10–11):E5–E7CrossRefPubMedGoogle Scholar
  48. 48.
    Choi GW, Yang JH, Seo HS, Kim WT, Lee MJ, Yoon JR (2016) Myopericytoma around the knee: mimicking a neurogenic tumour. Knee Surg Sports Traumatol Arthrosc 24(9):2748–2751.  https://doi.org/10.1007/s00167-014-3390-x CrossRefPubMedGoogle Scholar
  49. 49.
    Chotey NA, Naidu TK, Naidoo V, Naidoo J (2013) Myopericytoma of the external auditory canal and tragus. J Laryngol Otol 127(8):805–808.  https://doi.org/10.1017/s0022215113001357 CrossRefPubMedGoogle Scholar
  50. 50.
    Cianciulli TF, Lax JA, Saccheri MC, Lestard JP, Medawar MH, Zappi A, Neme RO (2016) Primary benign myopericytoma of the left atrium. J Echocardiogr 14(3):130–131.  https://doi.org/10.1007/s12574-016-0285-5 CrossRefPubMedGoogle Scholar
  51. 51.
    Datta V, Rawal YB, Mincer HH, Anderson MK (2007) Myopericytoma of the oral cavity. Head Neck 29(6):605–608.  https://doi.org/10.1002/hed.20548 CrossRefPubMedGoogle Scholar
  52. 52.
    Demir SS, Sarikaya A, Aktas GE, Oz Puyan F (2016) Incidental detection of subcutaneous myopericytoma of trunk on FDG PET/CT and bone scintigraphy for imaging of colon cancer. Clin Nucl Med 41(8):668–670.  https://doi.org/10.1097/rlu.0000000000001244 CrossRefPubMedGoogle Scholar
  53. 53.
    Dhingra S, Ayala A, Chai H, Moreno V, Zhao B (2012) Renal myopericytoma: case report and review of literature. Arch Pathol Lab Med 136(5):563–566.  https://doi.org/10.5858/arpa.2011-0387-CR CrossRefPubMedGoogle Scholar
  54. 54.
    Dray MS, McCarthy SW, Palmer AA, Bonar SF, Stalley PD, Marjoniemi V, Millar E, Scolyer RA (2006) Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases. J Clin Pathol 59(1):67–73.  https://doi.org/10.1136/jcp.2005.028704 CrossRefPubMedPubMedCentralGoogle Scholar
  55. 55.
    Edgecombe A, Peterson RA, Shamji FM, Commons S, Sekhon H, Gomes MM (2011) Myopericytoma: a pleural-based spindle cell neoplasm off the beaten path. Int J Surg Pathol 19(2):247–251.  https://doi.org/10.1177/1066896910381897 CrossRefPubMedGoogle Scholar
  56. 56.
    Harish S, O’Donnell P, Briggs TW, Saifuddin A, Flanagan AM (2007) Myopericytoma in Kager’s fat pad. Skeletal Radiol 36(2):165–169.  https://doi.org/10.1007/s00256-006-0108-2 CrossRefPubMedGoogle Scholar
  57. 57.
    Hodges K, Zou Y, Everett A, Murthy S, Ahmad U (2018) Pleural myopericytoma: a rare neoplasm in a difficult location. J Thorac Cardiovasc Surg.  https://doi.org/10.1016/j.jtcvs.2018.01.072 CrossRefPubMedGoogle Scholar
  58. 58.
    Holling M, Wildforster U, Verheggen R, Muller K, Stummer W, Jeibmann A (2015) Myopericytoma: a series of 5 cases affecting the nervous system. World Neurosurg 84(5):1493.e5–1493.e8.  https://doi.org/10.1016/j.wneu.2015.04.041 CrossRefGoogle Scholar
  59. 59.
    Hunald FA, Rakotoarisoa JC, Razafimahatratra R, Andriamampionona F, Ravalisoa A, Randrianjafisamindrakotroka N (2008) Thoracic myopericytoma in a child. A case report. Arch Pediatr 15(11):1660–1662.  https://doi.org/10.1016/j.arcped.2008.08.014 CrossRefPubMedGoogle Scholar
  60. 60.
    Ide F, Obara K, Yamada H, Mishima K, Saito I (2007) Intravascular myopericytoma of the oral mucosa: a rare histologic variant in an uncommon location. Virchows Arch 450(4):475–477.  https://doi.org/10.1007/s00428-007-0368-9 CrossRefPubMedGoogle Scholar
  61. 61.
    Inoue T, Misago N, Asami A, Tokunaga O, Narisawa Y (2016) Myopericytoma proliferating in an unusual anastomosing multinodular fashion. J Dermatol 43(5):557–559.  https://doi.org/10.1111/1346-8138.13161 CrossRefPubMedGoogle Scholar
  62. 62.
    Jairajpuri ZS, Hasan MJ, Madan GB, Jetley S (2016) Myopericytoma—a unifying term or a unique entity? Malays J Pathol 38(2):159–163PubMedGoogle Scholar
  63. 63.
    James AW, Chang L, Shrestha S, Tirado CA, Dry SM (2015) An unusual complex karyotype in myopericytoma. J Orthop 12(1):58–62.  https://doi.org/10.1016/j.jor.2015.01.015 CrossRefPubMedPubMedCentralGoogle Scholar
  64. 64.
    Jung YI, Chung YK, Chung S (2012) Multiple myopericytoma of the face and parotid gland. Arch Plast Surg 39(2):158–161.  https://doi.org/10.5999/aps.2012.39.2.158 CrossRefPubMedPubMedCentralGoogle Scholar
  65. 65.
    Kara A, Keskinbora M, Kayaalp ME, Seker A, Erdil M, Bulbul M (2014) An atypical presentation of myopericytoma in palmar arch and review of the literature. Case Rep Orthop.  https://doi.org/10.1155/2014/759329 CrossRefPubMedPubMedCentralGoogle Scholar
  66. 66.
    Kim EK, Lee JH, Kim SY, Kim GM (2013) Myopericytoma of the facial cheek. Ann Dermatol 25(1):122–124.  https://doi.org/10.5021/ad.2013.25.1.122 CrossRefPubMedPubMedCentralGoogle Scholar
  67. 67.
    Kuczkowski J, Rzepko R, Szurowska E (2010) Myopericytoma of the parotid gland—a pathological conundrum. J Craniomaxillofac Surg 38(8):595–596.  https://doi.org/10.1016/j.jcms.2009.10.024 CrossRefPubMedGoogle Scholar
  68. 68.
    Laga AC, Tajirian AL, Islam MN, Bhattacharyya I, Cohen DM, Plamondon CJ, Robinson-Bostom L (2008) Myopericytoma: report of two cases associated with trauma. J Cutan Pathol 35(9):866–870.  https://doi.org/10.1111/j.1600-0560.2007.00910.x CrossRefPubMedGoogle Scholar
  69. 69.
    Lee SK, Kwon SY (2009) Gray-scale and power Doppler sonography and CT findings of myopericytoma of the posterior cervical space. AJNR Am J Neuroradiol 30(8):1604–1606.  https://doi.org/10.3174/ajnr.A1535 CrossRefPubMedGoogle Scholar
  70. 70.
    Li J, You Q, Wang L, Xu L, Zhang H, Yu X (2015) Primary hepatic myopericytoma with rhabdoid-like cells: report of the first case and review of literature. Pathol Int 65(2):108–110.  https://doi.org/10.1111/pin.12240 CrossRefPubMedGoogle Scholar
  71. 71.
    Li J, Zhao M, Chen Z, Zou L, Teng X (2015) Renal myopericytoma: a clinicopathologic study of six cases and review of the literature. Int J Clin Exp Pathol 8(5):4307–4320PubMedPubMedCentralGoogle Scholar
  72. 72.
    Mahapatra P, Dunne J, Colville RJ (2015) Digital artery intravascular myopericytoma—a rare cause of a painful finger. J Hand Surg Am 40(7):753–754.  https://doi.org/10.1177/1753193414534380 CrossRefGoogle Scholar
  73. 73.
    Maheshwari V, Alam K, Jain A, Sharma SC (2008) Myopericytoma of neck region—a case report. Indian J Otolaryngol Head Neck Surg 60(2):179–180.  https://doi.org/10.1007/s12070-008-0047-4 CrossRefPubMedPubMedCentralGoogle Scholar
  74. 74.
    Michot A, Chaput B, Alet JM, Pelissier P (2016) Arterial myopericytoma resulting in Guyon’s canal syndrome. Hand Surg Rehabil 35(3):231–233.  https://doi.org/10.1016/j.hansur.2016.01.008 CrossRefPubMedGoogle Scholar
  75. 75.
    Morzycki A, Joukhadar N, Murphy A, Williams J (2017) Digital myopericytoma: a case report and systematic literature review. J Hand Microsurg 9(1):32–36.  https://doi.org/10.1055/s-0037-1601397 CrossRefPubMedPubMedCentralGoogle Scholar
  76. 76.
    Mun JM, Kim JI, Ko TY, Park SD (2018) Surgical treatment of primary pulmonary myopericytoma. Korean J Thorac Cardiovasc Surg 51(3):220–222.  https://doi.org/10.5090/kjtcs.2018.51.3.220 CrossRefPubMedPubMedCentralGoogle Scholar
  77. 77.
    Munakomi S, Chaudhary P (2016) Case Report: a giant myopericytoma involving the occipital region of the scalp—a rare entity. F1000Res 5:2905.  https://doi.org/10.12688/f1000research.10505.1 CrossRefPubMedPubMedCentralGoogle Scholar
  78. 78.
    Nagai T, Kamimura T, Itou K, Fujii M, Tsukino H, Mukai S, Akiyama Y, Kataoka H, Kamoto T (2017) Myopericytoma in urinary bladder: a case report. J Med Case Rep 11(1):46.  https://doi.org/10.1186/s13256-017-1226-2 CrossRefPubMedPubMedCentralGoogle Scholar
  79. 79.
    Numata I, Nakagawa S, Hasegawa S, Aiba S (2010) A myopericytoma of the nose. Acta Derm Venereol 90(2):192–193.  https://doi.org/10.2340/00015555-0790 CrossRefPubMedGoogle Scholar
  80. 80.
    Oliveira RC, Velasco R, Santos GR, Rebelo O (2018) Intracranial myopericytoma: a tumour in a rare location. BMJ Case Rep.  https://doi.org/10.1136/bcr-2017-223111 CrossRefPubMedGoogle Scholar
  81. 81.
    Orenay OM, Sarifakioglu E, Yildirim U (2016) A perivascular tumour on the wrist; myopericytoma. J Eur Acad Dermatol Venereol 30(4):709–710.  https://doi.org/10.1111/jdv.13006 CrossRefPubMedGoogle Scholar
  82. 82.
    Park HJ, Lee DR, Park MY, Choi YS, Lee DB (2010) A case of intravascular myopericytoma. J Clin Pathol 63(9):847–848.  https://doi.org/10.1136/jcp.2009.073601 CrossRefPubMedGoogle Scholar
  83. 83.
    Patrick A, Soares-de-Almeida L, Heinz K (2016) Malignant myopericytoma: report of a new case and review of the literature. Am J Dermatopathol 38(4):307–311.  https://doi.org/10.1097/dad.0000000000000463 CrossRefPubMedGoogle Scholar
  84. 84.
    Peters K, Caracciolo JT, Henderson-Jackson E, Binitie O (2018) Myopericytoma/myopericytomatosis of the lower extremity in two young patients: a recently designated rare soft tissue neoplasm. Radiol Case Rep 13(1):275–280.  https://doi.org/10.1016/j.radcr.2017.10.010 CrossRefPubMedGoogle Scholar
  85. 85.
    Prado-Calleros HM, Galarza-Lozano D, Arrieta-Gomez JR, Pombo-Nava A, Parraguirre-Martinez S, Gutierrez CJ (2016) Myopericytoma arising adjacent to the common carotid artery: case report and systematic review of deep located neck myopericytomas. Head Neck 38(9):E2479–E2482.  https://doi.org/10.1002/hed.24455 CrossRefPubMedGoogle Scholar
  86. 86.
    Provenzano D, Lo Bianco S, Belfiore M, Buffone A, Cannizzaro MA (2017) Foot soft tissue myopericytoma: case-report and review. Int J Surg Case Rep 41:377–382.  https://doi.org/10.1016/j.ijscr.2017.10.061 CrossRefPubMedPubMedCentralGoogle Scholar
  87. 87.
    Rho BH, Lee SK, Kwon SY (2011) Myopericytoma of the neck: sonographic appearance and sonographically guided needle biopsy. J Clin Ultrasound 39(8):469–472.  https://doi.org/10.1002/jcu.20827 CrossRefPubMedGoogle Scholar
  88. 88.
    Rodriguez D, Cornejo KM, Sadow PM, Santiago-Lastra Y, Feldman AS (2015) Myopericytoma tumor of the glans penis. Can J Urol 22(3):7830–7833PubMedGoogle Scholar
  89. 89.
    Rousseau A, Kujas M, van Effenterre R, Boch AL, Carpentier A, Leroy JP, Poirier J (2005) Primary intracranial myopericytoma: report of three cases and review of the literature. Neuropathol Appl Neurobiol 31(6):641–648.  https://doi.org/10.1111/j.1365-2990.2005.00681.x CrossRefPubMedGoogle Scholar
  90. 90.
    Rubino S, De Berardinis R, Colombo D, De Padova A (2017) Myopericytoma of the tongue base: a case report. Acta Otorrinolaringol Esp.  https://doi.org/10.1016/j.otorri.2017.06.010 CrossRefPubMedGoogle Scholar
  91. 91.
    Ruiz-Arriaga LF, Ramirez Teran AL, Ortiz-Hidalgo C, Fonte-Avalos V, Toussaint-Caire S, Vega-Memije ME, Anda-Juarez MC (2018) Myopericytoma in an unusual location. Dermatol Online J 24(4):pii:13030/qt5z02t0dkGoogle Scholar
  92. 92.
    Rullier A, Coindre JM, Sassoust G, Bioulac-Sage P, Lepreux S (2010) Arterial myopericytoma: a case report. Ann Pathol 30(4):325–327.  https://doi.org/10.1016/j.annpat.2010.05.014 CrossRefPubMedGoogle Scholar
  93. 93.
    Sadahira C, Yoneda K, Moriue T, Takai I, Kushida Y, Haba R, Kubota Y (2006) Periungual myopericytoma. J Am Acad Dermatol 54(6):1107–1108.  https://doi.org/10.1016/j.jaad.2006.01.057 CrossRefPubMedGoogle Scholar
  94. 94.
    Samaratunga H, Delahunt B (2015) Mesenchymal tumors of adult kidney. Semin Diagn Pathol 32(2):160–171.  https://doi.org/10.1053/j.semdp.2015.02.007 CrossRefPubMedGoogle Scholar
  95. 95.
    Sapelli S, Ribas M, Martins WD, de Noronha L, Gomes AP (2009) Myopericytoma of the lip: report of case. Head Neck 31(4):561–564.  https://doi.org/10.1002/hed.20933 CrossRefPubMedGoogle Scholar
  96. 96.
    Scott RS, Blank KL, Proffer LH, Kraus EW, Heim-Hall J (2006) Perivascular myoma of myopericytoma and myofibromatosis-type arising in a chronic scar. J Cutan Pathol 33(3):231–235.  https://doi.org/10.1111/j.0303-6987.2006.00401.x CrossRefPubMedGoogle Scholar
  97. 97.
    Song XL, Sun XY, Zhang GL, Yu YW, Wang CH (2012) Myopericytoma presenting as multiple pulmonary nodules. Intern Med 51(6):639–642CrossRefPubMedGoogle Scholar
  98. 98.
    Squillaci S, Cecchetti D, Tallarigo F, Pontieri F, Filardo AV (2005) Myopericytoma-type perivascular myoma located in the soft tissue of the foot: a case report and review of the literature. Pathologica 97(6):378–382PubMedGoogle Scholar
  99. 99.
    Strayer E, Throndson R, Clement C, McDaniel K (2018) Myopericytoma of the lip: a case report of this rare lesion. J Oral Maxillofac Surg 76(7):1464–1467.  https://doi.org/10.1016/j.joms.2018.02.003 CrossRefPubMedGoogle Scholar
  100. 100.
    Terada T (2010) Minute myopericytoma of the neck: a case report with literature review and differential diagnosis. Pathol Oncol Res 16(4):613–616.  https://doi.org/10.1007/s12253-010-9253-y CrossRefPubMedGoogle Scholar
  101. 101.
    Valero J, Salcini JL, Gordillo L, Gallart J, Gonzalez D, Deus J, Lahoz M (2015) Intravascular myopericytoma in the heel: case report and literature review. Medicine 94(11):e642.  https://doi.org/10.1097/md.0000000000000642 CrossRefPubMedPubMedCentralGoogle Scholar
  102. 102.
    Van Camp L, Goubau J, Van den Berghe I, Mermuys K (2018) Myopericytoma of the base of the finger: radiological and pathological description of a rare benign entity. J Hand Surg Am.  https://doi.org/10.1016/j.jhsa.2018.03.015 CrossRefPubMedGoogle Scholar
  103. 103.
    Vasenwala SM, Afroz N, Ansari HA, Khan AH, Basari R, Rehman S (2015) Myopericytoma of lip: a rare lesion in an unusual location. Indian J Pathol Microbiol 58(2):211–213.  https://doi.org/10.4103/0377-4929.155317 CrossRefPubMedGoogle Scholar
  104. 104.
    Wagner ER, Shin AY (2015) Myopericytoma of the hypothenar eminence: case report. Hand 10(2):349–352.  https://doi.org/10.1007/s11552-014-9655-5 CrossRefPubMedGoogle Scholar
  105. 105.
    Wilson T, Hellquist HB, Ray S, Pickles J (2007) Intranasal myopericytoma. A tumour with perivascular myoid differentiation: the changing nomenclature for haemangiopericytoma. J Laryngol Otol 121(8):786–789.  https://doi.org/10.1017/s0022215107007591 CrossRefPubMedGoogle Scholar
  106. 106.
    Wu F, Sun J, Dong J, Wang X, Gao Q (2013) Management of multicentric myopericytoma in the maxillofacial region: a case report. Case Rep Oncol 6(2):350–355.  https://doi.org/10.1159/000353625 CrossRefPubMedPubMedCentralGoogle Scholar
  107. 107.
    Xia CY, Liu H, Xu T, Wang J (2009) Intravascular myopericytoma beside the shinbone: a rare histological variant. J Clin Pathol 62(9):862–863.  https://doi.org/10.1136/jcp.2009.065672 CrossRefPubMedGoogle Scholar
  108. 108.
    Xia L, Chen Y, Geng N, Jiang J, Yang M, Zhang W (2010) Multifocal myopericytoma in the maxillofacial region: a case report. Oral Surg 109(2):e59–e62.  https://doi.org/10.1016/j.tripleo.2009.09.029 CrossRefGoogle Scholar
  109. 109.
    Yang JC, Venteicher AS, Koch MJ, Stapleton CJ, Friedman GN, Venteicher EM, Shin JH (2018) Myopericytoma at the craniocervical junction: clinicopathological report and review of a rare perivascular neoplasm. Neurosurgery.  https://doi.org/10.1093/neuros/nyy262 CrossRefPubMedGoogle Scholar
  110. 110.
    Zhang CH, Hasegawa H, Johns P, Martin AJ (2014) Myopericytoma of the posterior cranial fossa. Br J Neurosurg.  https://doi.org/10.3109/02688697.2014.952270 CrossRefPubMedGoogle Scholar
  111. 111.
    Zhang Z, Yu D, Shi H, Xie D (2014) Renal myopericytoma: a case report with a literature review. Oncol Lett 7(1):285–287.  https://doi.org/10.3892/ol.2013.1678 CrossRefPubMedGoogle Scholar
  112. 112.
    Fletcher CDM, Bridge JA, Hogendoorn P, Mertens F (2013) WHO Classification of Tumours. IARC WHO Classification of Tumours, No 5. WHO, LyonGoogle Scholar
  113. 113.
    Consortium A (2000) Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 26(3):345–348.  https://doi.org/10.1038/81664 CrossRefGoogle Scholar
  114. 114.
    Schapira D, Izhak BO, Nachtigal A, Burstein A, Shalom RB, Shagrawi I, Best LA (1995) Tumor-induced osteomalacia. Semin Arthritis Rheum 25(1):35–46CrossRefPubMedGoogle Scholar
  115. 115.
    Leitlinie des Dachverbands der Deutschsprachigen Wissenschaftlichen Osteologischen Gesellschaften e. V. bei postomenopausalen Frauen und Männern Prophylaxe, Diagnostik und Therapie der Osteoporose (2017) DVO.Google Scholar
  116. 116.
    Agaimy A, Michal M, Chiosea S, Petersson F, Hadravsky L, Kristiansen G, Horch RE, Schmolders J, Hartmann A, Haller F, Michal M (2017) Phosphaturic Mesenchymal Tumors: Clinicopathologic, Immunohistochemical and Molecular Analysis of 22 Cases Expanding their Morphologic and Immunophenotypic Spectrum. Am J Surg Pathol 41(10):1371–1380.  https://doi.org/10.1097/pas.0000000000000890 CrossRefPubMedGoogle Scholar

Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  • N. Muro Bushart
    • 1
    Email author
  • L. Tharun
    • 2
  • R. Oheim
    • 1
  • A. Paech
    • 1
  • J. Kiene
    • 1
  1. 1.Klinik für Orthopädie und UnfallchirurgieUKSH Campus LübeckLübeckDeutschland
  2. 2.Institut für PathologieUKSH Campus LübeckLübeckDeutschland

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