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Toxicity of Trimethyltin and Dimethyltin in Rats and Mice

  • Xiaojiang TangEmail author
  • Xin Wu
  • Amber M. Dubois
  • Gang Sui
  • Banghua Wu
  • Guanchao Lai
  • Zhihong Gong
  • Hongbin Gao
  • Shenglai Liu
  • Zhiyong Zhong
  • Zhongning Lin
  • James Olson
  • Xuefeng RenEmail author
Article

Abstract

Extensive uses of methyltin compounds in polyvinyl chloride (PVC) production have led to a dramatic increase of occupational-related methyltin poisoning accidents and the widespread contamination of methyltins in various environmental media. Here, we conducted studies to compare the acute toxicity induced by trimethyltin (TMT) and dimethyltin (DMT), and investigated the cumulative toxic effects of TMT in rats and mice. Neurobehavioral changes were observed in rats and mice treated with either DMT or TMT, but we also observed that both TMT and DMT exposure in rats significantly lowered the blood potassium level. Moreover, the cumulative toxic coefficient factor of TMT was 1.7 in rats versus 3.8 in mice, suggesting a high cumulative risk for rats and a moderate risk for mice. In summary, we demonstrated that acute and chronic exposure to methyltin compounds induced neurotoxicity and hypokalemia. Moreover, our study suggests that TMT can accumulate in the body and pose a risk for workers chronically exposed to a low dose of TMT.

Keywords

Acute toxicity Cumulative toxicity Dimethyltin Hypokalemia Trimethyltin 

Notes

Acknowledgments

This work was supported by the National Science Foundation of China (30771786, 30972458 to Tang, X), Guangdong Natural Science Foundation (S2012020011009 to Tang, X) and by a startup fund (to Ren, X) provided by the State University of New York at Buffalo.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Xiaojiang Tang
    • 1
    Email author
  • Xin Wu
    • 1
  • Amber M. Dubois
    • 2
    • 3
  • Gang Sui
    • 1
  • Banghua Wu
    • 4
  • Guanchao Lai
    • 4
  • Zhihong Gong
    • 2
  • Hongbin Gao
    • 4
  • Shenglai Liu
    • 1
  • Zhiyong Zhong
    • 1
  • Zhongning Lin
    • 5
  • James Olson
    • 2
    • 3
  • Xuefeng Ren
    • 1
    • 2
    • 3
    Email author
  1. 1.Guangdong Medical Laboratory Animal CenterFoshanChina
  2. 2.Social and Preventive MedicineThe State University of New York at BuffaloBuffaloUSA
  3. 3.Pharmacology and ToxicologyThe State University of New York at BuffaloBuffaloUSA
  4. 4.Guangdong Prevention and Treatment Center for Occupational DiseasesGuangzhouChina
  5. 5.School of Public HealthSun Yat-Sen UniversityGuangzhouChina

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