Polybrominated Diphenyl Ethers in Human Serum and Sperm Quality
- 413 Downloads
Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants; currently, they are identified as ubiquitous environmental contaminants. Several studies indicate that PBDEs might affect male fertility. We present the results of a pilot study on the relationship between human serum PBDEs and sperm quality. The PBDE levels in Japan are comparable to those found in European countries. Strong inverse correlations were observed between the serum concentration of 2,2′,4,4′,5,5′-hexabromodiphenyl ether and sperm concentration (r = −0.841, p = 0.002) and testis size (r = −0.764, p = 0.01). Extensive studies on the relationship between PBDEs and sperm quality are required.
KeywordsPolybrominated diphenyl ethers Flame retardants Human serum Sperm
We thank the participants who donated their blood and semen samples. This study was supported by grants from the Ministry of the Environment and the Ministry of the Health, Labor and Welfare, Japan.
- Geyer HJ, Schramm K-W, Darnerud PO, Aune M, Feicht A, Fried KW, Henkelmann B, Lenoir D, Schmid P, McDonald TA (2004) Terminal elimination half-lives of the brominated flame retardants TBBPA, HBCD, and lower brominated PBDEs in humans. Organohalogen Comp 66:3867–3872Google Scholar
- Ministry of the Environment, Japan (2006) Regarding brominated flame retardants (reference data 3). In: report on the survey of emissions of brominated dioxins and related compounds in fiscal year 2004. (in Japanese). Available: http://www.env.go.jp/air/report/h18-07/index.html [accessed 20 June, 2007]
- World Health Organization (1999) WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction, 4th edn. Cambridge University Press, CambridgeGoogle Scholar