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Cotinine Characterization and Quality Effect of Sperm for Smoking and Nonsmoking Students

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  1. Aitken RJ (1999) The human spermatozoon—a cell in crisis. J Reprod Fertil 115:1–7

  2. Bos RP, Henderson PT (1984) Genotoxic risk of passive smoking. Rev Environ Health 4:161–178

  3. Cummins JM, Jequier AM, Kan R (1994) Molecular biology of human male infertility: linked with aging, mitochondrial genetics, and oxidative stress. Mol Reprod Dev 37:345–362

  4. Field AE, Colditz GA, Willett WC, Longcope C, McKinlay JB (1994) The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men. J Clin Endocrinol Metab 79:1310–1316

  5. Health Promotion Bureau, Taiwan (2006) Annual report of Taiwan tobacco control in Taiwan. Taipei, Taiwan

  6. Howe G, Westhoff C, Vessey M, Yeastes D (1985) Effects of age, cigarette, smoking, and other factors on fertility: findings in a large prospective study. Br Med J 290:1697–1700

  7. Hulka BS (1991) Epidemiological studies using biological markers: issues for epidemiology. Cancer Epidemiol Biomarkers 1:13–19

  8. Jarvis MJ, Russell MAH, Benowitz NL, Feyerabend C (1988) Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure. Am J Public Health 78:696–698

  9. Jensen TK, Henriksen TB, Hjollund NH, Scheike T, Kolstad H, Giwercman A, Ernst E, Bonde JP, Skakkebaek NE, Olsen J (1998) Adult and prenatal exposures to tobacco smoke as risk indicators of fertility among 430 Danish couples. Am J Epidemiol 148:992–997

  10. Kuo CT, Teng YK (2001) Study on the effects of nicotine concentration on sperm quality. J Chin Med Sci 2:183–192

  11. Zenzes MT, Bielecki R, Reed TE (1999) Detection of benzo(a)pyrene diol epoxide DNA adducts in sperm of men exposed to cigarette smoke. Fertil Steril 72:330–335

  12. Oldereid NB, Rui H, Clausen OPH, Purvis K (1989) Cigarette smoking and human sperm quality assessed by laser-Doppler spectroscopy and DNA flow cytometry. J Reprod Fert 86:731–736

  13. Pacifici R, Alteri I, Gandini L, Lenzi A, Pichini S, Rosa M, Zuccaro P, Dondero F (1993) Nicotine, cotinine, and trans-3 hydroxycotinine levels in seminal plasma of smokers: effects on sperm parameters. Ther Drug Monit 15:358–363

  14. Vine MF, Hulka BS, Margolin BH, Truong YK, Hu PC, Schramm MM, Griffith JD, McCann M, Everson RB (1993) Cotinine concentrations in semen, urine, and blood of smokers and nonsmokers, Am J Public Health 83:1335–1338

  15. Vine MF (1996) Smoking and male reproduction: a view. Int J Androl 19:323–337

  16. Wall MA, Johnson J, Jacob P, Benowitz NL (1988) Cotinine in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers. Am J Public Health 78:699–701

  17. WHO (1992) Laboratory manual for examination of human semen and semen-cervical mucus interaction, 3rd edn. World Health Organization, Cambridge

  18. Yang ZS (2000) Study of the environmental and biological monitoring of airborne environmental tobacco smoking exposure. MD Thesis of Department of Public Health, China Medical University, Taiwan

  19. Zavos PM, Correa JR, Antypas S, Zarmakoupis-Zavos PN, Zarmakoupis CN (1998) Effects of seminal plasma from cigarette smokers on sperm viability and longevity. Fertil Steril 69:425–429

  20. Zenzes MT, Reed TE, Wang P, Klein J (1996) Cotinine, a major metabolite of nicotine, is detectable in follicular fluids of passive smokers in vitro fertilization therapy. Fertil Steril 66:614–619

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Correspondence to H.-W. Chen.

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Chen, H., Kuo, C. Cotinine Characterization and Quality Effect of Sperm for Smoking and Nonsmoking Students. Bull Environ Contam Toxicol 79, 11–14 (2007). https://doi.org/10.1007/s00128-007-9175-x

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  • Smoke
  • Cotinine
  • Seminal Plasma
  • Environmental Tobacco Smoke
  • Sperm Quality