Trends in prescriptions for sedative–hypnotics among Korean adults: a nationwide prescription database study for 2011–2015
This study investigated prescriptions for sedative–hypnotics via data obtained from the Health Insurance Review and Assessment (HIRA) service.
Data on sedative–hypnotic prescriptions from the HIRA service of the Republic of Korea were analyzed from 2011 to 2015. We included prescriptions for subjects > 18 years of age from hospitals and community healthcare centers. In addition, subgroup analyses with a subsample restricted to prescriptions from patients with diagnostic codes F510 (nonorganic insomnia) or G470 (insomnia) were performed. After analyzing the number of prescriptions by individual pharmacy items, the prescription codes were grouped as: (1) benzodiazepines; (2) non-benzodiazepines, including zolpidem; (3) antidepressants; and (4) antipsychotics. We calculated the monthly percent change in the number of prescriptions by drug group using Joinpoint regression.
Among the sedative–hypnotic groups, benzodiazepines were the most commonly prescribed drugs in Korea during the study period. As a single sedative–hypnotic item, zolpidem was the most frequently prescribed medication for patients with insomnia. Prescriptions for all groups of sedative–hypnotics increased significantly during the study period. When stratified by age group, antipsychotic prescriptions increased significantly by 0.19–0.21% per month among men and women aged 50–59 years and > 70 years. Prescriptions for antidepressants in 30–39-year-old men increased significantly by 0.20%.
Benzodiazepine prescriptions as well as those for antipsychotics and antidepressants to treat insomnia increased during 2011–2015 in Korea. Monitoring the use of sedative–hypnotics at the national level is necessary, especially in the elderly population.
KeywordsSedatives Hypnotics Prescription Insomnia
This study was supported by the research fund of the Mental Health Technology Development Project (Project No. HM15C1197).
Compliance with ethical standards
Conflict of interest
On behalf of all of the authors, the corresponding author states that there are no conflicts of interest.
- 3.Morphy H, Dunn KM, Lewis M, Boardman HF, Croft PR (2007) Epidemiology of insomnia: a longitudinal study in a UK population. Sleep 30:274–280Google Scholar
- 8.Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M (2008) Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med 4:487–504Google Scholar
- 14.OECD Health Statistics (2015) https://doi.org/10.1787/health-data-en. Accessed 10 Dec 17
- 17.Ford ES, Wheaton AG, Cunningham TJ, Giles WH, Chapman DP, Croft JB (2014) Trends in outpatient visits for insomnia, sleep apnea, and prescriptions for sleep medications among US adults: findings from the National Ambulatory Medical Care Survey 1999–2010. Sleep 37:1283–1293. https://doi.org/10.5665/sleep.3914 CrossRefGoogle Scholar
- 21.Korea Statistics Office (2017) http://kostat.go.kr. Accessed 10 Dec 17
- 26.Finnish Medical Society Duodecim and the Finnish Sleep Research Society working group (2008) Treatment of insomnia, current care guidelines. Duodecim 124:1782–1794Google Scholar