Asthma, life events and psychiatric disorders: a population-based study
- 353 Downloads
Although asthma and other chronic physical conditions have been shown to be associated with psychiatric symptoms, the relative contributions of negative life events to this association and impaired quality of life (QOL) are not clear.
This is a cross-sectional study of a nationally representative sample of Singaporean adults aged 20–59 (n = 2,847). Individuals were grouped by asthma, other chronic physical conditions, and no chronic physical conditions. Participants were assessed life events (list of threatening experiences questionnaire), psychiatric disorders [schedule for clinical assessment in neuropsychiatry diagnoses of psychiatric disorder including any psychiatric disorder, major depressive disorder (MDD) and generalized anxiety disorder (GAD)], and QOL (medical outcomes study 12-item short form).
In multivariate analyses controlling for confounding variables, asthma and other chronic physical conditions, compared to no chronic physical conditions, both showed similarly (two- to four-fold) elevated odds ratio (OR) of association with MDD and GAD. However, the asthma group reported more life events as compared to other chronic physical conditions (OR = 4.33, 95 % CI: 2.09–8.95) or no chronic physical conditions (OR = 7.64, 95 % CI: 3.87–15.06). Life events accounted significantly for excess coexistence of psychiatric disorders with asthma over participants without chronic physical conditions. It also contributed significantly to relatively worse QOL observed among individuals with asthma.
In this cross-sectional study, life events among adults in Singapore appeared to mediate the co-occurrence of psychiatric disorders and functional impairment with asthma, more than with other chronic physical conditions. This should be further investigated in longitudinal studies.
KeywordsAsthma Psychiatric disorder Life events Quality of life National Mental Health Survey
- 2.Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, Gibson P, Ohta K, O’Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ (2008) Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 31(1):143–178. doi:10.1183/09031936.00138707 PubMedCrossRefGoogle Scholar
- 3.Barreto do Carmo MB, Neves Santos D, Alves Ferreira Amorim LD, Fiaccone RL, Souza da Cunha S, Cunha Rodrigues L, Barreto ML (2009) Minor psychiatric disorders in mothers and asthma in children. Soc Psychiatry Psychiatr Epidemiol 44(5):416–420. doi:10.1007/s00127-008-0450-x PubMedCrossRefGoogle Scholar
- 7.Scott KM, Von Korff M, Ormel J, Zhang MY, Bruffaerts R, Alonso J, Kessler RC, Tachimori H, Karam E, Levinson D, Bromet EJ, Posada-Villa J, Gasquet I, Angermeyer MC, Borges G, de Girolamo G, Herman A, Haro JM (2007) Mental disorders among adults with asthma: results from the world mental health survey. Gen Hosp Psychiatry 29(2):123–133. doi:10.1016/j.genhosppsych.2006.12.006 PubMedCrossRefGoogle Scholar
- 9.Lavoie KL, Cartier A, Labrecque M, Bacon SL, Lemiere C, Malo JL, Lacoste G, Barone S, Verrier P, Ditto B (2005) Are psychiatric disorders associated with worse asthma control and quality of life in asthma patients? Respir Med 99(10):1249–1257. doi:10.1016/j.rmed.2005.03.003 PubMedCrossRefGoogle Scholar
- 13.Feldman JM, Acosta Perez E, Canino G, McQuaid EL, Goodwin RD, Ortega AN (2011) The role of caregiver major depression in the relationship between anxiety disorders and asthma attacks in island Puerto Rican youth and young adults. J Nerv Ment Dis 199(5):313–318. doi:10.1097/NMD.0b013e3182174e84 PubMedCrossRefGoogle Scholar
- 24.Goldberg DP (1988) A user’s guide to the general health questionnaire. NFER-NELSON Publishing Company, BerkshireGoogle Scholar
- 28.Goldberg DP (1972) The detection of psychiatric illness by questionnaire; a technique for the identification and assessment of non-psychotic psychiatric illness. Maudsley monographs vol no 21. Oxford University Press, LondonGoogle Scholar
- 31.Guze SB (1995) Diagnostic and statistical manual of mental-disorders, 4th edition (Dsm-Iv)—Amer-Psychiat-Assoc. Am J Psychiat 152:1228Google Scholar
- 33.Brugha TS, Nienhuis F, Bagchi D, Smith J, Meltzer H (1999) The survey form of SCAN: the feasibility of using experienced lay survey interviewers to administer a semi-structured systematic clinical assessment of psychotic and non-psychotic disorders. Psychol Med 29(3):703–711PubMedCrossRefGoogle Scholar
- 35.Ware JE, Kosinski M, Keller SD, QualityMetric I, New England Medical Center Hospital. Health Assessment L (2002) SF-12: how to score the SF-12 physical and mental health summary scales. QualityMetric Inc., Health Assessment Lab, Lincoln, R.I., Boston, MassGoogle Scholar
- 54.Kriegsman DM, Penninx BW, van Eijk JT, Boeke AJ, Deeg DJ (1996) Self-reports and general practitioner information on the presence of chronic diseases in community dwelling elderly. A study on the accuracy of patients’ self-reports and on determinants of inaccuracy. J Clin Epidemiol 49(12):1407–1417PubMedCrossRefGoogle Scholar