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Are attitudes towards medication adherence associated with medication adherence behaviours among patients with psychosis? A systematic review and meta analysis

  • Michelle RichardsonEmail author
  • Rose McCabe
  • Stefan Priebe
Original Paper

Abstract

Background

Studies have shown patient attitudes to be an important predictor for health related behaviours including medication adherence. It is less clear whether patient attitudes are also associated with medication adherence among patients with psychoses.

Method

We conducted a systematic review and meta analysis of the data of studies that tested the association of attitude measures with medication adherence among patients with psychoses. 14 studies conducted between 1980 and 2010 were included.

Results

Results show a small to moderate mean weighted effect size (r + = 0.25 and 0.26 for Pearson and Spearman correlations, respectively).

Conclusions

Theory based interventions that target potentially modifiable attitude components are needed to assess the relationship between positive patient attitudes and adherence behaviours among patients with psychoses.

Keywords

Medication adherence Attitudes Psychoses 

References

  1. 1.
    Young JL, Zonana HV, Shepler L (1986) Medication non-compliance in schizophrenia: codification and update. Bull Am Acad Psychiatr Law 14:105–122Google Scholar
  2. 2.
    Velligan DI, Lam YWF, Glahn DC, Barrett JA, Maples NJ, Ereshefsky L, Miller AL (2006) Defining and assessing adherence to oral antipsychotics: a review of the literature. Schizophr Bull 32:724–742PubMedCrossRefGoogle Scholar
  3. 3.
    Kamali M, Kelly BD, Clarke M, Browne M, Gervin S, Kinsella A, Lane A, Larkin C, O’Callaghan E (2006) A prospective evaluation of adherence to medication in first episode schizophrenia. Eur Psychiatry 21(1):29–33PubMedCrossRefGoogle Scholar
  4. 4.
    Pinikahana J (2005) Determinants of medication compliance in schizophrenia in Pletson, J. E.(Ed.). Progress in Schizophrenia research. Nova Science Publishers, Inc. Hauppauge, NY, pp. 131–148Google Scholar
  5. 5.
    Thieda P, Beard S, Ritchter A, Kane J (2003) An economic review of adherence with medication therapy in the treatment of schizophrenia. Psychiatr Serv 54:508–516PubMedCrossRefGoogle Scholar
  6. 6.
    Lacro JP, Dunn LB, Dolder CR et al (2002) Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature. J Clin Psychiatry 63:892–908PubMedCrossRefGoogle Scholar
  7. 7.
    Reininghaus U, McCabe R, Burns T, Croudace T, Priebe S (2010) Measuring patients’ views: a bi-factor model of distinct patient-reported outcomes in psychosis. Psychol Med 21:1–13Google Scholar
  8. 8.
    Becker MH, Haefner DP, Maiman LA (1977) The health belief model of prediction of dietary compliance: a field experiment. J Health Soc Behav 18:348–366PubMedCrossRefGoogle Scholar
  9. 9.
    Ajzen I (1991) The theory of planned behaviour. Organ Behav Hum Decis Process 50:179–211CrossRefGoogle Scholar
  10. 10.
    Dolder CR, Larco JP, Warren KA, Golshan S, Perkins D, Jeste DV (2004) Brief evaluation of medication influences and beliefs. Development and testing of a brief scale for Medication Adherence. J Clin Psychopharmacol 24(4):404–409PubMedCrossRefGoogle Scholar
  11. 11.
    Kopelowicz A, Wallace CJ, Liberman RP, Aguirre F, Zarate R, Mintz J (2007) The use of the theory of planned behaviour to predict medication adherence in schizophrenia. Clin Schizophr Relat Psychoses. 1(3):227–242CrossRefGoogle Scholar
  12. 12.
    Reid LD, Christensen DB (1988) A psychosocial perspective in the explanation of patients’ drug taking behaviour. Soc Sci Med 27:277–285CrossRefGoogle Scholar
  13. 13.
    Brwonlee-Duffeck M, Peterson L, Simonds JF, Goldstein D, Kilo C, Hoette S (1987) The role for health beliefs in the regimen adherence and metabolic control of adolescents and adults with diabetes mellitus. Soc Sci Med 55:139–144Google Scholar
  14. 14.
    Murphy DA, Greenwell L, Hoffman D (2002) Factors associated with antiretroviral adherence among HIV-infected women with children. Women Health 36:97–111PubMedCrossRefGoogle Scholar
  15. 15.
    Abraham C, Clift S, Grabowsk P (1999) Cognitive predictors of adherence to malaria prophylaxis regimens on return from a malarious region: a prospective study. Soc Sci Med 48:1641–1654PubMedCrossRefGoogle Scholar
  16. 16.
    Hogan TP, Awad AG, Eastwood R (1983) A self-report scale predictive of drug compliance in schizophrenics : reliability and discriminative validity. Psychol Med 13:177–183PubMedCrossRefGoogle Scholar
  17. 17.
    Weiden P, Rapkin B, Mott T (1994) Rating of medication influences (ROMI) scale in schizophrenia. Schizophr Bull 20:197–310CrossRefGoogle Scholar
  18. 18.
    Becker MH, Haefner DP, Kasl SV et al (1977) Selected psychosocial models and correlates of individual health-related behaviours. Med Care 15 (supplement):27–46Google Scholar
  19. 19.
    Hunter JE, Schmidt FL (2004) Methods of meta-analysis: correcting error and bias in research findings, 2nd edn. Sage Publications, Newbury ParkGoogle Scholar
  20. 20.
    Katsakou C, Priebe S (2007) Patient’s experiences of involuntary hospital admission and treatment: a review of qualitative studies. Epidemiol Psichiatr Soc 16:172–178PubMedGoogle Scholar
  21. 21.
    Duval S, Tweedie R (2000) A nonparametric “trim and fill” method of accounting for publication bias in meta-analysis. J Am Stat Assoc 95:89–98Google Scholar
  22. 22.
    National Research Council (1992) Combining information: statistical issues and opportunities for research. National Academy Press, Washington, D.CGoogle Scholar
  23. 23.
    Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560PubMedCrossRefGoogle Scholar
  24. 24.
    Greenwald AG (1975) Consequences of prejudice against the null hypothesis. Psychol Bull 82:1–20CrossRefGoogle Scholar
  25. 25.
    Agarwal MR, Sharma VK, Kishore Kumar KV, Lowe D (1998) Non-compliance with treatment in patients suffering from schizophrenia: a study to evaluate possible contributing factors. Int J Soc Psychiatry 44:92–106PubMedCrossRefGoogle Scholar
  26. 26.
    Cabeza IG, Amador MS, Lopez CA, de Chavez MG (2000) Subjective response to antipsychotics in schizophrenic patients: clinical implications and related factors. Schizophr Res 41(2):349–355PubMedCrossRefGoogle Scholar
  27. 27.
    Donohoe G, Ownes N, O’Donell C, Burke T, Morre L, Tobin A, O’Callaghan EO (2001) Predictos of compliance with neuroleptic medication among inpatients with schizophrenia: a discriminant function analysis. Eur Psychiatry 16:293–298PubMedCrossRefGoogle Scholar
  28. 28.
    Fialko L, Garety PA, Kuipers E, Dunn G, Bebbington PE, Fowler D, Freeman D (2008) A large-scale validation study of the medication adherence rating scale (MARS). Schizophr Res 100:53–59PubMedCrossRefGoogle Scholar
  29. 29.
    Haan DL, Amelsvoort VT, Dingsmans P, Linszen D (2007) Risk factors for medication non-adherence in patients with first episode schizophrenia and related disorders; A prospective five year follow –up. Pharmacopsychiatry 40:1–5CrossRefGoogle Scholar
  30. 30.
    Hayward P, Chan N, Kemp R et al (1995) Medication selfmanagement: a preliminary report of an intervention to improve medication compliance. J Ment Health 4:511–517CrossRefGoogle Scholar
  31. 31.
    Kelly GR, Mamon JA, Scott JE (1987) Utility of the Health Belief Model in examining medication compliance among psychiatric outpatients. Soc Sci Med 25:1205–1211PubMedCrossRefGoogle Scholar
  32. 32.
    Kennedy FC, Seth R, Sinclair S, Levey S, Bentall RP (2003) Patients’ appraisals of neuroleptic medication: the measurement and predictive utility of attitudes. Prim Care Community 9(1):21–27CrossRefGoogle Scholar
  33. 33.
    Mutsatsa SH, Joyce EM, Hutton SB et al (2003) Clinical correlates of early medication adherence: West London first episode schizophrenia study. Acta Psychiatr Scand 108:439–446PubMedCrossRefGoogle Scholar
  34. 34.
    Quach PL, Mors O, Christensen TO, Krarup G, Jorgensen P, Bertelsen M, Jeppesen P, Petersen L, Thorup A, Nordentoft M (2009) Predictors of poor adherence to medication among patients with first-episode schizophrenia spectrum-disorder. Early Interv Psychiatry 3(1):66–74PubMedCrossRefGoogle Scholar
  35. 35.
    Tsang HWH, Fung KMT, Corrigan PW (2009) Psychosocial and socio-demographic correlates of medication compliance among people with schizophrenia. J Behav Ther Exp Psychiatry 40:3–14PubMedCrossRefGoogle Scholar
  36. 36.
    Kamali M, Kelly L, Gervin M, Browne S, Larkin C, O’Callaghan E (2000) The prevalence of comorbid substance misuse and its influence on suicidal ideation among in-patients with schizophrenia. Acta Psychiatr Scand 101(6):452–456PubMedCrossRefGoogle Scholar
  37. 37.
    Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta analysis. Stat Med 21:1539–1558PubMedCrossRefGoogle Scholar
  38. 38.
    Abraham C, Michie S (2008) A taxonomy of behaviour change techniques used in interventions. Br J Health Psychol 27(3):379–387CrossRefGoogle Scholar
  39. 39.
    Murgraff V, McDermott MR, Abraham C (2007) Reducing Friday alcohol consumption among moderate, women drinkers: evaluation of a brief evidence-based intervention. Alcohol Alcohol Am J Drug Alcohol Abuse 42(1):37–41CrossRefGoogle Scholar
  40. 40.
    Lin IF, Spiga R, Fortsch W (1979) Insight and adherence to medication in chronic schizophrenics. J Clin Psychiatry 40:430–432Google Scholar
  41. 41.
    Adams SG Jr, Howe JT (1993) Predicting medication compliance in a psychotic population J Nerv Ment Dis 181:558–560Google Scholar
  42. 42.
    Kemp R, Hayward P, Applewhaite G, Everitt B, David A (1996) Compliance therapy in psychotic patients: randomised controlled trial. BMJ 312:345–349Google Scholar
  43. 43.
    Hall M, Meaden A, Smith J et al (2001) Brief report: the development and psychometric properties of an observer-rated measure of engagement with mental health services. J Ment Health 10(4):457–465Google Scholar
  44. 44.
    Kamali M, Kelly L, Gervin M et al (2001) Insight and comorbid substance misuse and medication compliance among patients with schizophrenia. Psychiatr Serv 52:161–163Google Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Michelle Richardson
    • 1
    Email author
  • Rose McCabe
    • 1
  • Stefan Priebe
    • 1
  1. 1.Unit for Social and Community Psychiatry, Barts and the London School of MedicineQueen Mary University of LondonLondonUK

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