Social Psychiatry and Psychiatric Epidemiology

, Volume 46, Issue 12, pp 1303–1312 | Cite as

Specific medical conditions associated with clinically significant depressive symptoms in men

  • Evan Atlantis
  • Kylie Lange
  • Robert D. Goldney
  • Sean Martin
  • Matthew T. Haren
  • Anne Taylor
  • Peter D. O’Loughlin
  • Villis Marshall
  • Wayne Tilley
  • Gary A. Wittert
Original Paper



To define specific medical conditions associated with clinically significant depressive symptoms in men.


A cross-sectional study was conducted in a community-based sample of Australian men (N = 1,195, aged 35–80 years; for 2002–2005). Depression was defined by: (1) symptomatic depression (current symptoms) or (2) current prescription for antidepressant(s) or (3) previously diagnosed depression. Logistic regression was used to determine prevalence odds ratios (OR) for depression independently associated with an extensive range of demographic, lifestyle, and clinical factors. Adjusted population attributable risk (PAR%) estimates were also computed.


Depression was significantly (ORs at P < 0.05) associated with previously diagnosed anxiety (12.0) and insomnia (4.4), not married (1.7), current smoker (1.7), low muscle strength tertile (1.7, P = 0.059), high triglycerides (1.6), high storage lower urinary tract symptoms (LUTS) tertile (1.8), past year general practitioner visits 5–9 (1.9), middle energy density tertile (0.4), and high systolic blood pressure (0.5). Significant PAR% estimates (at P < 0.05) were for previous anxiety (27.0%) and insomnia (16.1%), middle energy density tertile (−17.2%), high SBP (−23.5%), high triglycerides (15.2%), and high storage LUTS tertile (12.6%). Results strengthened when depression-related factors (previous anxiety and insomnia, psycholeptics, and cognition) were omitted, and became significant for CVD (OR 1.6; PAR 13.9%).


Medical conditions associated with depression in men include high triglycerides, low muscle strength, CVD, and LUTS. Depressed men are likely to use health services frequently, be current smokers, not be married, eat unhealthily, and report previous diagnosis of anxiety and insomnia; which has important implications for clinicians managing male patients.


Depression Cardiovascular disease Muscle strength Triglycerides LUTS 

Supplementary material

127_2010_302_MOESM1_ESM.doc (172 kb)
Supplementary material 1 (DOC 172 kb)


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Evan Atlantis
    • 1
    • 2
  • Kylie Lange
    • 3
  • Robert D. Goldney
    • 4
    • 5
  • Sean Martin
    • 2
  • Matthew T. Haren
    • 6
  • Anne Taylor
    • 6
  • Peter D. O’Loughlin
    • 1
    • 2
  • Villis Marshall
    • 2
  • Wayne Tilley
    • 1
    • 2
    • 7
  • Gary A. Wittert
    • 1
    • 2
    • 3
  1. 1.Royal Adelaide Hospital/Institute of Medical and Veterinary ScienceSouth Australia Health, Government of South AustraliaAdelaideAustralia
  2. 2.School of Medicine, Freemasons Foundation Centre for Men’s HealthThe University of AdelaideAdelaideAustralia
  3. 3.School of Medicine, Centre of Clinical Research Excellence in Nutritional Physiology, Interventions and OutcomesThe University of AdelaideAdelaideAustralia
  4. 4.Discipline of PsychiatryThe University of AdelaideAdelaideAustralia
  5. 5.Hanson Institute, SA PathologyRoyal Adelaide HospitalAdelaideAustralia
  6. 6.Division of Health Sciences, SANSOM InstituteUniversity of South AustraliaAdelaideAustralia
  7. 7.School of Medicine, Dame Roma Mitchell Cancer Research Laboratories and Discipline of MedicineThe University of AdelaideAdelaideAustralia

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