Skip to main content

Advertisement

Log in

Epidemiology of antidepressant medication use in the Canadian diabetes population

  • Original Paper
  • Published:
Social Psychiatry and Psychiatric Epidemiology Aims and scope Submit manuscript

Abstract

Background

Depression has been shown to be a common co-morbidity in diabetes. From a public health point of view, there is a lack of population-based studies regarding the use of antidepressant medication in non-clinical samples of people with diabetes. The objective of the present study was to provide demographic and clinical information about the use of antidepressant medication in a representative community sample of people with diabetes.

Method

The Canadian Community Health Survey 1.2 (CCHS 1.2) is a cross-sectional survey that collects information related to health status, health-care utilization and health determinants of the Canadian general population. Diabetes presence was ascertained by self-report of physician diagnosis. Depression and anxiety were assessed using a modified version of the World Mental Health Composite International Diagnostic Interview. Antidepressant use was determined through self-report.

Results

The population prevalence of self-reported antidepressant use in the past 12 months was 8.4% (SE = 0.95) among people with diabetes (n = 1,662). People who took antidepressants had higher average body mass index (M = 32.6, SD = 6.5) than those not taking antidepressants (M = 29.2, SD = 5.7). The use of antidepressants was associated with poorer health status and higher number of co-morbid chronic conditions. Half of diabetes subjects who used antidepressant medication in the last year did not have a lifetime history of major depression.

Conclusions

In a community sample of people with diabetes, the prevalence of antidepressant use exceeded the prevalence of major depression. Anxiety disorders and other somatic chronic conditions were associated with the prescription of antidepressant medication in people with diabetes, but without a history of major depression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Andrews G, Slade T (2001) Interpreting scores on the Kessler Psychological Distress Scale (K10). Aust N Z J Public Health 25:494

    Article  CAS  PubMed  Google Scholar 

  2. Beck CA, Patten SB, Williams JVA, Jian Li W, Currie SR, Maxwell CJ, El-Guebaly N (2005) Antidepressant utilization in Canada. Soc Psychiatry Psychiatr Epidemiol 40:799–807

    Article  PubMed  Google Scholar 

  3. Cairney J, Veldhuizen S, Wade TJ, Kurdyak P, Streiner DL (2007) Evaluation of 2 measures of psychological distress as screeners for depression in the general population. Can J Psychiatry 52:111–120

    PubMed  Google Scholar 

  4. Demyttenaere K, Jaspers L (2008) Bupropion and SSRI-induced side effects. J Psychopharmacol 22:792–804

    Article  CAS  PubMed  Google Scholar 

  5. Deshmukh R, Franco K (2003) Managing weight gain as a side effect of antidepressant therapy. Cleve Clin J Med 70:614–623

    Article  PubMed  Google Scholar 

  6. Furukawa TA, Kessler RC, Slade T, Andrews G (2003) The performance of the K6 and K10 screening scales for psychological distress in the Australian National Survey of Mental Health and Well-Being. Psychol Med 33:357–362

    Article  CAS  PubMed  Google Scholar 

  7. Ghaemi SN, Lenox MS, Baldessarini RJ (2001) Effectiveness and safety of long-term antidepressant treatment in bipolar disorder. J Clin Psychiatry 62:565–569

    CAS  PubMed  Google Scholar 

  8. Gonzalez JS, Peyrot M, McCarl LA et al (2008) Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care 31:2398–2403

    Article  PubMed  Google Scholar 

  9. Gonzalez JS, Safren SA, Cagliero E, Wexler DJ, Delahanty L, Wittenberg E et al (2007) Depression, self-care, and medication adherence in type 2 diabetes: relationships across the full range of symptom severity. Diabetes Care 30:2222–2227

    Article  PubMed  Google Scholar 

  10. Goodnick PJ (2001) Use of antidepressants in treatment of comorbid diabetes mellitus and depression as well as in diabetic neuropathy. Ann Clin Psychiatry 13:31–41

    CAS  PubMed  Google Scholar 

  11. Hirschfeld R, Keller M, Panico S, Arons B, Barlow D, Davidoff F, Endicott J, Froom J, Goldstein M, Gorman J, Marek R, Maurer T, Meyer R, Phillips K, Ross J, Schwenk T, Sharfstein S, Thase M, Wyatt R (1997) The National Depressive and Manic-Depressive Association consensus statement on the undertreatment of depression. JAMA 277:333–340

    Article  CAS  PubMed  Google Scholar 

  12. Idler EL, Benyamini Y (1997) Self-rated health and mortality: a review of twenty-seven community studies. J Health Soc Behav 38:21–37

    Article  CAS  PubMed  Google Scholar 

  13. Katon W, Lin EHB, Kroenke K (2007) The association of depression and anxiety with medical symptom burden in patients with chronic medical illness. Gen Hosp Psychiatry 29:147–155

    Article  PubMed  Google Scholar 

  14. Katon WJ, Von Korff M, Lin EHB, Simon G, Ludman E, Russo J, Ciechanowski P, Walker E, Bush T (2004) The pathways study: a randomized trial of collaborative care in patients with diabetes and depression. Arch Gen Psychiatry 61:1042–1049

    Article  PubMed  Google Scholar 

  15. Katon WJ, Rutter C, Simon G, Lin EH, Ludman E, Ciechanowski P et al (2005) The association of comorbid depression with mortality in patients with type 2 diabetes. Diabetes Care 28:2668–2672

    Article  PubMed  Google Scholar 

  16. Keller MB, McCullough JP, Klein DN, Arnow B, Dunner DL, Gelenberg AJ, Markowitz JC, Nemeroff CB, Russell JM, Thase ME, Trivedi MH, Zajecka J (2000) A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression. N Engl J Med 342:1462–1470

    Article  CAS  PubMed  Google Scholar 

  17. Kennedy SH (2006) A review of antidepressant treatments today. Eur Neuropsychopharmacol 16:S619–S623

    Article  CAS  Google Scholar 

  18. Kessler RC, Ustün TB (2004) The World Mental Health (WMH) survey initiative version of the World Health Organization (WHO) composite. International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res 13:93–121

    Article  PubMed  Google Scholar 

  19. Kessler R, Andrews G, Colpe L, Hiripi E, Mroczek D, Normand S, Walters E, Zaslavsky A (2002) Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med 32:959–976

    Article  CAS  PubMed  Google Scholar 

  20. Lin EHB, Von Korff M (2008) Mental disorders among persons with diabetes-Results from the World Mental Health Surveys. J Pyschosom Res 65:571–580

    Article  Google Scholar 

  21. Lustman PJ, Freedland KE, Griffith LS, Clouse RE (2000) Fluoxetine for depression in diabetes: a randomized double-blind placebo-controlled trial. Diabetes Care 23:618–623

    Article  CAS  PubMed  Google Scholar 

  22. Lustman PJ, Griffith LS, Clouse RE, Freedland KE, Eisen SA, Rubin EH, Carney RM, McGill JB (1997) Effects of nortriptyline on depression and glycemic control in diabetes: results of a double-blind, placebo-controlled trial. Psychosom Med 59:241–250

    CAS  PubMed  Google Scholar 

  23. Lustman PJ, Griffith LS, Freedland KE, Kissel SS, Clouse RE (1998) Cognitive behavior therapy for depression in type 2 diabetes mellitus: a randomized, controlled trial. Ann Intern Med 129:613–621

    CAS  PubMed  Google Scholar 

  24. McCollum M, Ellis SL, Regensteiner JG, Zhang W, Sullivan PW (2007) Minor depression and health status among US adults with diabetes mellitus. Am J Manag Care 13:65–72

    PubMed  Google Scholar 

  25. McIntyre RS, Soczynska JK, Konarski JZ, Kennedy SH (2006) The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms. Expert Opin Drug Saf 5:157–168

    Article  CAS  PubMed  Google Scholar 

  26. McIntyre RS, Soczynska JK, Konarski JZ, Kennedy SH (2006) The effect of antidepressants on lipid homeostasis: a cardiac safety concern? Expert Opin Drug Saf 5:523–537

    Article  CAS  PubMed  Google Scholar 

  27. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors. JAMA 289:76–79

    Article  PubMed  Google Scholar 

  28. National Institutes of Health (1998) Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res 6:51–209

    Google Scholar 

  29. Ohayon MM, Caulet M, Priest RG, Guilleminault C (1998) Psychotropic medication consumption patterns in the UK general population. J Clin Epidemiol 51:273–283

    Article  CAS  PubMed  Google Scholar 

  30. Okura Y, Urban LH, Mahoney DW, Jacobsen SJ, Rodeheffer RJ (2004) Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure. J Clin Epidemiol 57:1096–1103

    Article  PubMed  Google Scholar 

  31. Radloff LS (1977) The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1:385–401

    Article  Google Scholar 

  32. Rubin RR, Ma Y, Marrero DG, Peyrot M, Barrett-Connor EL, Kahn SE et al (2008) Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program. Diabetes Care 31:420–426

    Article  PubMed  Google Scholar 

  33. Statistics Canada (2002) A profile of disability in Canada. Canadian Research Index 2002, Ottawa

  34. The Diabetes Prevention Program Research Group (2005) Depression symptoms and antidepressant medicine use in diabetes prevention program participants. Diabetes Care 28:830–837

    Article  Google Scholar 

  35. Tunks ER, Weir R, Crook J (2008) Epidemiologic perspective on chronic pain treatment. Can J Psychiatry 53:235–242

    PubMed  Google Scholar 

  36. Williams JW Jr, Katon W, Lin EHB, Noel PH, Worchel J, Cornell J, Harpole L, Fultz BA, Hunkeler E, Mika VS, Unutzer J (2004) The effectiveness of depression care management on diabetes-related outcomes in older patients. Ann Intern Med 140:1015–1024

    PubMed  Google Scholar 

  37. Wittchen HU (1994) Reliability and validity studies of the WHO-Composite International Diagnostic Interview (CIDI): a critical review. J Psychiatr Res 28:57–84

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This analysis is based on Statistics Canada’s Canadian Community Health Survey, Cycle 1.2 (2005), public use microdata file which contains anonymized collected data. All computations on these microdata were prepared by Anna Ivanova, Danit Nitka, and Norbert Schmitz, and the responsibility for the use and interpretation of these data is entirely that of the authors. All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. This research was funded by the Canadian Institutes for Health Research (CIHR Grant MOP-79464) and a FRSQ Chercheur-Boursier fellowship to Dr Schmitz.

Conflict of interest statement

Nothing to declare.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Norbert Schmitz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ivanova, A., Nitka, D. & Schmitz, N. Epidemiology of antidepressant medication use in the Canadian diabetes population. Soc Psychiat Epidemiol 45, 911–919 (2010). https://doi.org/10.1007/s00127-009-0129-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00127-009-0129-y

Keywords

Navigation