Psychiatric disorders among infertile and fertile women

  • Ahmad Ali Noorbala
  • Fatemeh Ramezanzadeh
  • Nasrin Abedinia
  • Mohammad Mehdi Naghizadeh


This study was performed in order to determine the prevalence and predisposing factors of psychiatric disorders among infertile and fertile women attending Vali-e-Asr Hospital. A total of 150 fertile women from Vali-e-Asr Reproduction Health Research Center and fertile women from the Gynecology Clinic of Imam Khomeini Hospital were chosen by consecutive sampling. Data included demographic information, SCL-90-R, and a semi-structured questionnaire about stress factors. Results showed that 44% of infertile and 28.7% of fertile women had a psychiatric disorder (P < 0.001). Using the SCL-90-R test, the highest mean scores in infertile women were found to be on the paranoid ideation, depression and interpersonal sensitivity scales, and lowest scores were found on the psychoticism and phobic anxiety scales. The interpersonal sensitivity, depression, phobic anxiety, paranoid ideas and psychoticism scales were significantly different between infertile and fertile women (P < 0.05). Infertile women were at higher risk of developing psychiatric disorders if they were housewives rather than working women (P = 0.001). Considering the high prevalence of psychiatric disorders among infertile women, it seems that gynecologists, psychiatrists and psychologists should be more attentive to identify and treat these disorders. The use of psychotherapy, especially supportive methods, should be considered as part of the general therapeutic framework of infertility.


psychiatric disorders infertility SCL-90-R 


  1. 1.
    Abbasi-Shavazi MJ, Inhorn MC, Razeghi-Nasrabad HB, Toloo G (2008) The “Iranian ART Revolution”: infertility, assisted reproductive technology, and third-party donation in the Islamic Republic of Iran. J Middle East Women’s Stud 4:1558–9579Google Scholar
  2. 2.
    Andrews FM, Abbey A, Halman LJ (1992) Is fertility-problem stress different? The dynamics of stress in fertile and infertile couples. Fertil Steril 57:1247–1253PubMedGoogle Scholar
  3. 3.
    Bagheri Yazdi SA, Bolhari J, Shahmohammadi D (1994) Psychiatric disorders in the rural district of Meybod (Yazd, Iran). Q J Andisheh Raftar (Persian) 1(1)Google Scholar
  4. 4.
    Berg B, Wilson J (1991) Psychological functioning across stages of treatment for infertility. J Behav Med 14:11–26PubMedCrossRefGoogle Scholar
  5. 5.
    Bjorn J, Tonkelaar O-I, Nieuwenhuyse H (1999) Psycho social experiences in women facing fertility problems—a comparative survey. Hum Reprod 14:255–261CrossRefGoogle Scholar
  6. 6.
    Boivin J (2003) A review of psychosocial interventions in infertility. Soc Sci Med 57:2325–2341PubMedCrossRefGoogle Scholar
  7. 7.
    Coleman R, Morison L, Paine K, Richard A, Walraven PJ (2006) Women’s reproductive health and depression. A community survey in the Gambia, West Africa. Soc Psychiatry Epidemiol 41:720–727CrossRefGoogle Scholar
  8. 8.
    Demyttenare K, Nijs P, Evers-Kiebooms G, Konickx PR (1989) The effect of specific emotional stressor on prolactine, cortisol and testosterone concentrations in women varies with their trait anxiety. Fertil Steril 52:942–948Google Scholar
  9. 9.
    Derogatis LR, Lipman RS, Covi L (1973) SCL-90-R an outpatient psychiatric rating scale-preliminary report. Psychopharmacol Bull 9:13–28PubMedGoogle Scholar
  10. 10.
    Domar A, Broome A, Zuttersmeister P (eds) (1992) The prevalence and predictability of depression in infertile women. Fertil Steril 58:1158–1163PubMedGoogle Scholar
  11. 11.
    Dyer ST, Abrahams N, Mokoena NE, Lombard CJ, Van derspuy ZM (2005) Psychological distress among women suffering from Couple infertility in South Africa: a quantitative assessment. Hum Reprod 20:1938–1943PubMedCrossRefGoogle Scholar
  12. 12.
    Freeman EW, Rickels K, Tausig J (eds) (1987) Emotional and psychological factors in follow-up women after IVF-ET treatment: a pilot investigation. Acta Obstet Gynecol Scand 66:517–521PubMedCrossRefGoogle Scholar
  13. 13.
    Golombok S (1992) Psychological functioning in infertility patients. Hum Reprod 7:208–212PubMedGoogle Scholar
  14. 14.
    Guerra D, Liobera A, Veiga A, Barri PN (1998) Psychiatric morbidity in couples attending a Fertility service. Hum Reprod 13:1733–1736PubMedCrossRefGoogle Scholar
  15. 15.
    Keye WR (1984) Psychosexual responses to infertility. Clin Obstet Gynecol 27:760–766PubMedCrossRefGoogle Scholar
  16. 16.
    Lu Y, Yang L, Lu G (1995) Mental status and personality of infertile women. Zhonghua Fu Chan Ke Za Zh 30:34–37Google Scholar
  17. 17.
    Manlstedt PP, Macduff S, Bemstein J (1987) Emotional factors and the in vitro fertilization and embryo transfer process. J In Vitro Fert Embryo Transf 4(4):232–236CrossRefGoogle Scholar
  18. 18.
    Mc Mahon CA, Ungerer JA, Beaurepaire J (eds) (1997) Anxiety during pregnancy and fetal attachment after in-vitro fertilization conception. Hum Reprod 12:176–182CrossRefGoogle Scholar
  19. 19.
    Menning BF (1975) The infertile couple: a plea for advocacy. Child Welf 54:454–460Google Scholar
  20. 20.
    Merari D, Feldberg D, Elizur A (eds) (1992) Psychological and hormonal changes in the course of in vitro fertilization. J Assist Reprod Genet 9:161PubMedCrossRefGoogle Scholar
  21. 21.
    Noorbala AA, Mohammad K, Bagheri Yazdi SA (1999) Prevalence of psychiatric disorders in Tehran (Iran). Hakim J 2:214–223Google Scholar
  22. 22.
    Noorbala AA, Ramezanzadeh F, Malakafzali H, Abedinia N et al (2008) Effects of a psychological intervention on depression in infertile couples. Int J Gynaecol Obstet 3:248–522CrossRefGoogle Scholar
  23. 23.
    Pfeffer N, Woollett A (eds) (1983) The experience of infertility. Virago Press, LondonGoogle Scholar
  24. 24.
    Seible MM, Taymor ML (1982) Emotional aspects of infertility. Fertil Steril 37:137–145Google Scholar
  25. 25.
    Slade P, Emery J, Lieberman BA (1997) A prospective, longitudinal study of emotional relationship in vitro fertilization treatment. Hum Reprod 12:183–190PubMedCrossRefGoogle Scholar
  26. 26.
    Tartatzis I, Bc Tarlatzis, Diakogiannis I (eds) (1993) Psychosocial impacts of infertility on Greek couples. Hum Reprod 8:396–401Google Scholar
  27. 27.
    Wischmann T, Stammer H, Scherg H, Gerhard I, Verres R (2001) Psychosocial characteristics of infertile souples: a study by the Heidelberg Fertility Consultation service. Hum Reprod 16:1753–1761PubMedCrossRefGoogle Scholar
  28. 28.
    Wright J, Bissonnette F, Duchesne C (eds) (1991) Psychosocial distress and infertility: men and women respond differently. Fertil Steril 55:100–108PubMedGoogle Scholar

Copyright information

© Steinkopff Verlag Darmstadt 2008

Authors and Affiliations

  • Ahmad Ali Noorbala
    • 1
  • Fatemeh Ramezanzadeh
    • 2
  • Nasrin Abedinia
    • 2
  • Mohammad Mehdi Naghizadeh
    • 2
  1. 1.Psychiatric and Psychology Research Center, Roozbeh HospitalTehran University of Medical SciencesTehranIran
  2. 2.Gynecology Group, Vali-e-Asr Reproduction Health Research Center, Imam Khomeini Hospital ComplexTehran University of Medical SciencesTehranIran

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