Predictors of general quality of life and the mediating role of health related quality of life in patients with schizophrenia
- First Online:
- 234 Downloads
The concept ‘quality of life’ (QoL) has become increasingly important as an outcome measure in the evaluation of services and in clinical trials of people with schizophrenia. This study examines the mediating role of health related quality of life (HRQoL) in the prediction of general quality of life (GQoL).
QoL and other patient- and illness characteristics (psychopathology, overall functioning, illness history, self-esteem and social integration) were measured in a group of 143 outpatients with schizophrenia. GQoL was measured by the Lancashire Quality of Life Profile and HRQoL was measured by the MOS SF-36. To test the temporal stability of our findings, assessments were performed twice with an 18-month interval.
We found that patient’s GQoL is predicted mainly by anxiety and depression and self-esteem and to a lesser extent by global functioning and social integration. At both time intervals HRQoL appeared to be a significant mediator of the relationship between anxiety and depression and self esteem versus patient’s GQoL.
The results of this study are important for mental health professionals, as these provide more insight in the mechanisms by which they could improve the GQoL of their patients with schizophrenia. The results confirm that diagnosis and treatment of anxiety and depression in outpatients with schizophrenia deserves careful attention of clinicians. Also strategies and specific interventions to improve self-esteem of patients with schizophrenia are very important to maximise patient’s QoL.
KeywordsSchizophrenia quality of life Lancashire Quality of Life Profile MOS SF-36
- 8.Gaite L, Vazquez-Barquero JL, Borra C, Ballesteros J, Schene A, Welcher B, Thornicroft G, Becker T, Ruggeri M, Herran A, the EPSILON Study Group (2002) Quality of life in patients with schizophrenia in five European countries: the EPSILON study. Acta Psychiatr Scand 105:283–392PubMedCrossRefGoogle Scholar
- 17.Leese M, Schene A, Koeter M, Meijer K, Bindman J, Mazzi M, Puschner B, Burti L, Becker T, Moreno M, Celani D, White IR, Thonicroft G (2008) SF-36 scales, and simple sums of scales, were reliable quality-of-life summaries for patients with schizophrenia. J Clin Epidemiol 61:588–596PubMedCrossRefGoogle Scholar
- 20.Van Nieuwenhuizen Ch, Schene AH, Boevink WA, Wolf JRLM (1997) Measuring the quality of Life of clients with severe mental illness: a review of instruments. Psychiatr Rehabil J 20:33–41Google Scholar
- 26.Rosenberg M (1965) Society and the adolescent self image. Princeton University Press, PrincetonGoogle Scholar
- 32.Tollefson GD, Andersen SW (1999) Should we consider mood disturbance in schizophrenia as an important determinant of quality of life? J Clin Psychiatry 60:s23–s29Google Scholar
- 35.Ware JE, Kosinski MA, Keller SD (1994) SF-36 physical and mental health summary scales: a user’s manual. The Health Institute, New England Medical Center, BostonGoogle Scholar