, Volume 44, Issue 12, pp 2115–2133 | Cite as

A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis

  • D. L. Eizirik
  • T. Mandrup-Poulsen


Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death could indicate novel sites for therapeutic intervention in Type I (insulin-dependent) diabetes mellitus. We review the molecular effectors and signal transduction of immune-mediated beta-cell apoptosis.

Keywords Beta cell apoptosis interleukin-1 interferon-γ nitric oxide diabetes mellitus. 

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • D. L. Eizirik
    • 1
  • T. Mandrup-Poulsen
    • 2
  1. 1.Gene Expression Unit, Diabetes Research Center, Vrije Universiteit Brussel, Brussels, BelgiumBE
  2. 2.Steno Diabetes Center, Gentofte, DenmarkDK

Personalised recommendations