Diabetologia

, Volume 44, Issue 12, pp 2107–2114

Postprandial blood glucose as a risk factor for cardiovascular disease in Type II diabetes: the epidemiological evidence

  • E. Bonora
  • M. Muggeo
Reviews

DOI: 10.1007/s001250100020

Cite this article as:
Bonora, E. & Muggeo, M. Diabetologia (2001) 44: 2107. doi:10.1007/s001250100020

Abstract.

That cardiovascular disease occurs more frequently in patients with Type II (non-insulin-dependent) diabetes mellitus has been recognized for a long time. However, the extent to which hyperglycaemia contributes to atherosclerosis and cardiovascular disease is still not clear. Epidemiological studies published in recent years suggest that postprandial blood glucose might be an independent risk factor of cardiovascular disease. The main results of these studies, which are reviewed in this article, are that subjects from the general population with mild to moderate hyperglycaemia, following oral glucose load, but not in the fasting state, showed an increased cardiovascular risk. Furthermore, the post-challenge as well as postprandial glucose concentrations of subjects with Type II diabetes were found to be directly associated to incident cardiovascular disease independently of fasting glucose. Also, the correction of fasting hyperglycaemia or HbA1 c or both, disregarding the specific correction of postprandial hyperglycaemia was not found to significantly reduce the incidence of cardiovascular disease in patients with Type II diabetes. Finally, the strict control of both preprandial and postprandial hyperglycaemia yielded a substantial reduction of cardiovascular disease in Type II diabetes. Trials specifically designed to address this issue are needed to determine whether postprandial hyperglycaemia plays an independent and causative role in cardiovascular disease in patients with Type II diabetes. [Diabetologia (2001) 44: 2107–2114]

Keywords Type II diabetes cardiovascular disease fasting glucose postprandial glucose HbA1 c. 

Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • E. Bonora
    • 1
  • M. Muggeo
    • 1
  1. 1.Division of Endocrinology and Metabolic Disease, University of Verona Medical School, Verona, ItalyIT

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