Diabetologia

, Volume 42, Issue 10, pp 1195–1198

Antibodies to tissue transglutaminase C in Type I diabetes

  • V. Lampasona
  • R. Bonfanti
  • E. Bazzigaluppi
  • A. Venerando
  • G. Chiumello
  • E. Bosi
  • E. Bonifacio
Short communications

DOI: 10.1007/s001250051291

Cite this article as:
Lampasona, V., Bonfanti, R., Bazzigaluppi, E. et al. Diabetologia (1999) 42: 1195. doi:10.1007/s001250051291

Abstract

Aims/hypothesis. Silent coeliac disease is a gluten driven autoimmune disease which is relatively frequent in patients with Type I (insulin-dependent) diabetes mellitus. To determine the extent of gluten associated autoimmunity in Type I diabetes, autoantibodies to tissue transglutaminase C, a major autoantigen in coeliac disease, were measured in patients with new-onset Type I diabetes. Methods. We measured IgG and IgA tissue transglutaminase C autoantibodies using human recombinant antigen and radio-binding assays in a cohort of 287 patients with new-onset Type I diabetes, 119 with Type II (non-insulin-dependent) diabetes mellitus and in 213 control subjects. Results. We found IgA and IgG tissue transglutaminase C antibodies in 24 (8 %) patients with Type I diabetes; 97 (33 %) patients had IgG antibodies only and 1 IgA antibodies only. Antibody concentrations were highest in those with both IgA and IgG antibodies. Only 2 (2 %) patients with Type II diabetes and 2 (1 %) control subjects had either IgG or IgA tissue transglutaminase C antibodies. Patients with HLA DRB1*04 alleles had the highest prevalence of IgG tissue transglutaminase C antibodies. Conclusion/Interpretation. These data show that almost 10 % of patients have autoimmunity typical of coeliac disease and that another 30 % have low level tissue transglutaminase C antibody binding. This high prevalence suggests either involvement of the gut in the pathogenesis of Type I diabetes or that transglutaminase is a secondary autoantigen resulting from beta-cell destruction. [Diabetologia (1999) 42: 1195–1198]

Keywords Type I diabetes autoantibodies coeliac disease transglutaminase. 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • V. Lampasona
    • 1
  • R. Bonfanti
    • 2
  • E. Bazzigaluppi
    • 3
  • A. Venerando
    • 3
  • G. Chiumello
    • 2
  • E. Bosi
    • 3
  • E. Bonifacio
    • 3
  1. 1.Department of Laboratory Medicine, San Raffaele Scientific Institute, Milan, ItalyIT
  2. 2.Department of Paediatrics, San Raffaele Scientific Institute, Milan, ItalyIT
  3. 3.Department of Medicine 1, San Raffaele Scientific Institute, Milan, ItalyIT

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