Diabetologia

, Volume 42, Issue 3, pp 292–296 | Cite as

Type I (insulin-dependent) diabetes mellitus and cow milk: casein variant consumption

  • R. B. Elliott
  • D. P. Harris
  • J. P. Hill
  • N. J. Bibby
  • H. E. Wasmuth
Articles

Summary

Previously published Type I (insulin-dependent) diabetes mellitus incidence in 0 to 14-year-old children from 10 countries or areas was compared with the national annual cow milk protein consumption. Countries which were selected for study had appropriate milk protein polymorphism studies, herd breed composition information and low dairy imports from other countries. Total protein consumption did not correlate with diabetes incidence (r = + 0.402), but consumption of the β-casein A1 variant did (r = + 0.726). Even more pronounced was the relation between β-casein (A1 + B) consumption and diabetes (r = + 0.982). These latter two cow caseins yield a bioactive peptide β-casomorphin-7 after in vitro digestion with intestinal enzymes whereas the common A2 variant or the corresponding human or goat caseins do not. β-casomorphin-7 has opioid properties including immunosuppression, which could account for the specificity of the relation between the consumption of some but not all β-casein variants and diabetes incidence. [Diabetologia (1999) 42: 292–296]

Keywords Milk casein epidemiology immunosuppression beta-casomorphin. 

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • R. B. Elliott
    • 1
  • D. P. Harris
    • 2
  • J. P. Hill
    • 2
  • N. J. Bibby
    • 1
  • H. E. Wasmuth
    • 3
  1. 1.Department of Paediatrics, School of Medicine, Auckland, New ZealandNZ
  2. 2.Food Science Section, New Zealand Dairy Research Institute, Palmerston North, New ZealandNZ
  3. 3.Diabetes Research Institute, University of Düsseldorf, GermanyDE

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