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VEGF-A and blood vessels: a beta cell perspective

  • Willem Staels
  • Yves Heremans
  • Harry Heimberg
  • Nico De LeuEmail author
Review

Abstract

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult pancreas, islets depend on their dense capillary network to adequately respond to changes in plasma glucose levels. Vascular changes contribute to the onset and progression of both type 1 and type 2 diabetes. Impaired revascularisation of islets transplanted in individuals with type 1 diabetes is linked to islet graft failure and graft loss. This review summarises our understanding of the role of vascular endothelial growth factor-A (VEGF-A) and endothelial cells in beta cell development, physiology and disease. In addition, the therapeutic potential of modulating VEGF-A levels in beta and beta-like cells for transplantation is discussed.

Keywords

Blood vessels Diabetes Endothelial cells Pancreatic beta cells Review VEGF-A 

Abbreviations

Ang

Angiopoietin

BOEC

Blood outgrowth endothelial cell

E

Embryonic day

FGF

Fibroblast growth factor

HGF

Hepatocyte growth factor

IBMIR

Instant blood-mediated inflammatory response

RTK

Receptor tyrosine kinase

VEGF

Vascular endothelial growth factor

VEGFR

Vascular endothelial growth factor receptor

Notes

Acknowledgements

We would like to acknowledge all researchers that contributed to the field. We would also like to thank our colleagues and members of the Beta Cell Neogenesis laboratory. We apologise to scientists whose work could not be highlighted because of space limitations.

Contribution statement

WS and NDL were responsible for drafting the article. All authors revised it critically for important intellectual content. All authors approved the version to be published.

Funding

The authors acknowledge support by grants from the Research Foundation Flanders (FWO), the VUB Research Council, Stichting Diabetes Onderzoek Nederland, the European Union Sixth and Seventh Framework Program, the Wetenschappelijk Fonds Willy Gepts (WFWG) of the UZ Brussel and the European Foundation for the Study of Diabetes. WS is supported by a postdoctoral grant from Agence Nationale de la Recherche (Laboratoire d’Excellence Revive, Investissement d’Avenir; ANR-10-LABX-73).

Duality of interest

The authors declare that there is no duality of interest associated with this manuscript.

Supplementary material

125_2019_4969_MOESM1_ESM.pptx (286 kb)
Figure slide (PPTX 286 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Beta Cell Neogenesis (BENE)Vrije Universiteit BrusselBrusselsBelgium
  2. 2.Institut Cochin, CNRS, INSERMUniversité de ParisParisFrance
  3. 3.Department of EndocrinologyUZ BrusselBrusselsBelgium
  4. 4.Department of EndocrinologyASZ AalstAalstBelgium

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