Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Blood Mg2+ is more closely associated with hyperglycaemia than with hypertriacylglycerolaemia: the PREVEND study

This is a preview of subscription content, log in to check access.

Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.



Prevention of Renal and Vascular End-stage Disease


  1. 1.

    Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A (2000) Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta Int J Clin Chem 294(1–2):1–26.

  2. 2.

    Gommers LMM, Hoenderop JGJ, Bindels RJM, de Baaij JHF (2016) Hypomagnesemia in type 2 diabetes: a vicious circle? Diabetes 65(1):3–13.

  3. 3.

    Schutten JC, Gomes-Neto AW, Navis G et al (2019) Lower plasma magnesium, measured by nuclear magnetic resonance spectroscopy, is associated with increased risk of developing type 2 diabetes mellitus in women: results from a Dutch prospective cohort study. J Clin Med 8(2):169.

  4. 4.

    Kurstjens S, de Baaij JHF, Overmars-Bos C et al (2019) Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+. Diabetologia 62(2):311–321.

  5. 5.

    Kurstjens S, de Baaij JHF, Bouras H, Bindels RJM, Tack CJJ, Hoenderop JGJ (2017) Determinants of hypomagnesemia in patients with type 2 diabetes mellitus. Eur J Endocrinol 176(1):11–19.

  6. 6.

    Gruppen EG, Connelly MA, Vart P, Otvos JD, Bakker SJ, Dullaart RP (2016) GlycA, a novel proinflammatory glycoprotein biomarker, and high-sensitivity C-reactive protein are inversely associated with sodium intake after controlling for adiposity: the Prevention of Renal and Vascular End-Stage Disease study. Am J Clin Nutr 104(2):415–422.

  7. 7.

    Matyus SP, Braun PJ, Wolak-Dinsmore J et al (2014) NMR measurement of LDL particle number using the Vantera Clinical Analyzer. Clin Biochem 47(16–17):203–210.

Download references


This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

Author information

All authors were responsible for drafting the article and revising it critically for important intellectual content. All authors approved the version to be published. RPFD is the guarantor of this work.

Correspondence to Peter R. van Dijk.

Ethics declarations

The authors declare that there is no duality of interest associated with this manuscript.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

van Dijk, P.R., Schutten, J.C., Jeyarajah, E.J. et al. Blood Mg2+ is more closely associated with hyperglycaemia than with hypertriacylglycerolaemia: the PREVEND study. Diabetologia 62, 1732–1734 (2019).

Download citation


  • Hyperglycaemia
  • Magnesium
  • Nuclear magnetic resonance spectroscopy
  • Triacylglycerols
  • Type 2 diabetes mellitus