Autoantibody binding in liquid phase to IL-2 in human sera is not type 1 diabetes specific
KeywordsAutoantibodies Autoimmunity ELISA IL-2 Immunoprecipitation LIPS Type 1 diabetes
Luciferase immunoprecipitation system
Recombinant IL-2 tagged with a NanoLuc luciferase reporter
Area under the receiver operator characteristic curve
We wish to thank the BioBank of the Immunohematology and Transfusion Medicine Unit, led by L. Santoleri at the San Raffaele Scientific Institute, Milan, Italy, for their assistance in sample collection and retrieval.
Data generated in this study are available from the authors upon request.
This study was conducted within the framework of the Italian Ministry of Research’s project ‘Ivascomar project, Cluster Tecnologico Nazionale Scienze della Vita ALISEI’.
Duality of interest
The authors declare that there is no duality of interest associated with this manuscript.
IM, DL, CB, RB, AS and PM acquired and analysed the data. EB, LP and VL designed the study, analysed the data and wrote the manuscript. All authors revised and approved the final version of the manuscript. VL is responsible for the integrity of the work as a whole.