, Volume 57, Issue 10, pp 2232–2234 | Cite as

An explanation for recent discrepancies in levels of human circulating betatrophin

  • Zhiyao Fu
  • Abdul B. Abou-Samra
  • Ren ZhangEmail author

To the Editor: In addition to hyperglycaemia and hyperinsulinaemia, type 2 diabetes mellitus is often associated with hypertriglyceridaemia. Recently, we and others have identified a novel circulating factor, referred to as lipasin [1], refeeding induced in fat and liver (RIFL) [2], angiopoietin-like protein 8 (ANGPTL8) [3, 4], and betatrophin [5], which may have a dual role in mediating both triacylglycerol metabolism and glucose homeostasis.

Lipasin mRNA levels in liver and fat, where it is predominantly expressed, are suppressed by fasting and highly induced by feeding and insulin resistance [1, 2, 3, 5]. Serum triacylglycerol levels are increased in lipasin overexpressing mice and decreased in lipasin knockout mice, and this likely occurs through a mechanism involving regulation of the activity of lipoprotein lipase (LPL) either directly [1] or indirectly by promoting ANGPTL3 cleavage [3]. Indeed, the knockout mice exhibit higher LPL activity [4]. The discovery of betatrophin as a...


ANGPTL8 Betatrophin C19orf80 Lipasin RIFL 



Angiopoietin-like protein


Lipoprotein lipase


Note added in proof

Consistent with the result of negative correlation between betatrophin and BMI based on the N-terminal kit (Fig. 1c), in a recent study, Gómez-Ambrosi et al [11] showed that circulating betatrophin is decreased in obesity.


This work was supported by a startup fund from Wayne State University to RZ.

Duality of interest

The authors confirm that there is no duality of interest associated with this manuscript.

Contribution statement

ZF performed the experiments, analysed the data and participated in manuscript revision. ABA-S participated in data analysis and manuscript revision. RZ designed the study, analysed the data and wrote the manuscript. All authors have approved the final version. RZ is the guarantor of this work.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Center for Molecular Medicine and Genetics, School of MedicineWayne State UniversityDetroitUSA
  2. 2.Department of MedicineHamad Medical CorporationDohaQatar

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