An explanation for recent discrepancies in levels of human circulating betatrophin
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KeywordsANGPTL8 Betatrophin C19orf80 Lipasin RIFL
Note added in proof
Consistent with the result of negative correlation between betatrophin and BMI based on the N-terminal kit (Fig. 1c), in a recent study, Gómez-Ambrosi et al  showed that circulating betatrophin is decreased in obesity.
This work was supported by a startup fund from Wayne State University to RZ.
Duality of interest
The authors confirm that there is no duality of interest associated with this manuscript.
ZF performed the experiments, analysed the data and participated in manuscript revision. ABA-S participated in data analysis and manuscript revision. RZ designed the study, analysed the data and wrote the manuscript. All authors have approved the final version. RZ is the guarantor of this work.
- 10.Chang JK, Lyu RM, Chen XQ et al (2013) Detection of C-terminal betatrophin peptides in human plasma and rodent liver. In: Nishiuchi Y, Teshima T (eds) The 4th Asia-Pacific International Peptide Symposium. Peptide Science, Japan, pp 243–246Google Scholar
- 11.Gómez-Ambrosi J, Pascual E, Catalán V et al (2014) Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes. J Clin Endocrinol Metab (in press)Google Scholar