, Volume 57, Issue 4, pp 841–843 | Cite as

Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study

  • Lars KrogvoldEmail author
  • Bjørn Edwin
  • Trond Buanes
  • Johnny Ludvigsson
  • Olle Korsgren
  • Heikki Hyöty
  • Gun Frisk
  • Kristian F. Hanssen
  • Knut Dahl-Jørgensen
Research Letter

To the Editor: There is a serious lack of information for all involved in type 1 diabetes treatment and research: what is happening in the insulin-producing cells and local environment as the disease evolves? Type 1 diabetes is a serious disease [1], but despite extensive research, the causes are still unknown.

The location of the pancreas in close proximity to vital organs is an obvious reason why studies of pancreatic tissue from patients with newly diagnosed type 1 diabetes have rarely been undertaken. With improved laparoscopic surgical techniques, the risks associated with a laparoscopic pancreatic tail resection have decreased. Within our team, surgeons have developed considerable expertise in this technique [2], expecting a very low frequency of complications after limited tail resections in otherwise healthy young diabetic patients.

Previously, studies have been carried out using punching to collect small samples of pancreatic tissue from recent-onset type 1 diabetic patients [


Aetiology Complications Ethics Laparoscopy Pancreatic pathology Type 1 diabetes 



Diabetes Virus Detection Study



The authors thank: specialist nurse T. Roald, Children’s Department, Oslo University Hospital, Norway, who has provided invaluable efforts in coordination of the study; nurses and doctors at the local hospitals for providing contact with the patients; and finally the patients who participated in this study.


The project was funded by South-Eastern Norway Regional Health Authority and through the Persistent Virus Infection in Diabetes Network (PEVNET) Study Group funded by the European Union's Seventh Framework Programme [FP7/2007-2013] under grant agreement no 261441 PEVNET. The participants of the PEVNET consortium are described at

Duality of interest

The authors declare that there is no duality of interest associated with this manuscript.

Contribution statement

All authors were responsible for the conception and drafting of the manuscript, and approved the final version for publication.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Lars Krogvold
    • 1
    Email author
  • Bjørn Edwin
    • 2
  • Trond Buanes
    • 2
  • Johnny Ludvigsson
    • 3
  • Olle Korsgren
    • 4
  • Heikki Hyöty
    • 5
    • 6
  • Gun Frisk
    • 4
  • Kristian F. Hanssen
    • 7
  • Knut Dahl-Jørgensen
    • 1
  1. 1.Paediatric DepartmentOslo University Hospital HFOsloNorway
  2. 2.Department of SurgeryOslo University HospitalOsloNorway
  3. 3.Division of Paediatrics, Department of Clinical and Experimental MedicineLinköping UniversityLinköpingSweden
  4. 4.Department of Immunology, Genetics and PathologyUppsala UniversityUppsalaSweden
  5. 5.School of MedicineUniversity of TampereTampereFinland
  6. 6.Fimlab LaboratoriesPirkanmaa Hospital DistrictTampereFinland
  7. 7.Department of EndocrinologyOslo University HospitalOsloNorway

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