Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study
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To the Editor: There is a serious lack of information for all involved in type 1 diabetes treatment and research: what is happening in the insulin-producing cells and local environment as the disease evolves? Type 1 diabetes is a serious disease , but despite extensive research, the causes are still unknown.
The location of the pancreas in close proximity to vital organs is an obvious reason why studies of pancreatic tissue from patients with newly diagnosed type 1 diabetes have rarely been undertaken. With improved laparoscopic surgical techniques, the risks associated with a laparoscopic pancreatic tail resection have decreased. Within our team, surgeons have developed considerable expertise in this technique , expecting a very low frequency of complications after limited tail resections in otherwise healthy young diabetic patients.
Previously, studies have been carried out using punching to collect small samples of pancreatic tissue from recent-onset type 1 diabetic patients [
KeywordsAetiology Complications Ethics Laparoscopy Pancreatic pathology Type 1 diabetes
Diabetes Virus Detection Study
The authors thank: specialist nurse T. Roald, Children’s Department, Oslo University Hospital, Norway, who has provided invaluable efforts in coordination of the study; nurses and doctors at the local hospitals for providing contact with the patients; and finally the patients who participated in this study.
The project was funded by South-Eastern Norway Regional Health Authority and through the Persistent Virus Infection in Diabetes Network (PEVNET) Study Group funded by the European Union's Seventh Framework Programme [FP7/2007-2013] under grant agreement no 261441 PEVNET. The participants of the PEVNET consortium are described at www.uta.fi/med/pevnet/consortium.html.
Duality of interest
The authors declare that there is no duality of interest associated with this manuscript.
All authors were responsible for the conception and drafting of the manuscript, and approved the final version for publication.