Outcome data on individuals with diabetic foot ulcers are scarce, especially in those with peripheral arterial disease (PAD). We therefore examined the clinical characteristics that best predict poor outcome in a large population of diabetic foot ulcer patients and examined whether such predictors differ between patients with and without PAD.
Analyses were conducted within the EURODIALE Study, a prospective cohort study of 1,088 diabetic foot ulcer patients across 14 centres in Europe. Multiple logistic regression modelling was used to identify independent predictors of outcome (i.e. non-healing of the foot ulcer).
After 1 year of follow-up, 23% of the patients had not healed. Independent baseline predictors of non-healing in the whole study population were older age, male sex, heart failure, the inability to stand or walk without help, end-stage renal disease, larger ulcer size, peripheral neuropathy and PAD. When analyses were performed according to PAD status, infection emerged as a specific predictor of non-healing in PAD patients only.
Predictors of healing differ between patients with and without PAD, suggesting that diabetic foot ulcers with or without concomitant PAD should be defined as two separate disease states. The observed negative impact of infection on healing that was confined to patients with PAD needs further investigation.
Diabetic foot ulcers are a common and much feared complication of diabetes, with recent studies suggesting that the lifetime risk of developing a foot ulcer in diabetic patients may be as high as 25% . Foot ulceration requires long and intensive treatment, has important effects on quality of life of both patients and care-givers  and is associated with major healthcare costs [3–5]. Although in recent years much effort has been put into the development of international guidelines in order to stimulate the delivery of uniform and structured care , prospective data on outcomes and predictors of outcome in patients with diabetic foot ulcers are limited.
The population of diabetic patients who present with foot ulceration is heterogeneous: although most patients have peripheral polyneuropathy, there are several other characteristics that may vary among patients, such as the presence of peripheral arterial disease (PAD), infection and co-morbidities. PAD is present in approximately one-half of all patients with foot ulcers  and is considered an important predictor of outcome [8, 9]. Therefore, outcome data on this important subgroup of patients with diabetic foot disease are needed. Such a requirement is underlined by the fact that although diabetic foot ulcers are usually reported and analysed as one clinical entity, marked differences in patient, foot and ulcer characteristics can exist between patients with and without PAD . These observations raise the question of whether predictors of outcome in patients with and without PAD may differ.
The aim of the present study was therefore: (1) to obtain prospective data on outcome of individuals presenting with a new diabetic foot ulcer, including patients both with and without PAD; (2) to assess clinical characteristics that best predict poor outcome (i.e. non-healing of the foot ulcer) from this large set of patients; and (3) to examine whether such predictors differ between patients with and without PAD.
Study design and population
The EURODIALE consortium is an international collaborative network that was created to stimulate further research in the field of diabetic foot disease. Its main objective was to assess outcome and the major predictors of clinical outcome in a large sample of European patients with diabetic foot ulcers. The design and rationale of this study have been described in detail elsewhere .
Briefly, between 1 September 2003 and 1 October 2004, 1,232 patients with a new foot ulcer were included in 14 diabetic foot centres in ten European countries. The mean (range) number of included patients per centre was 88 (40–125). All participating centres have a longstanding expertise in the field of diabetic foot disease. Patients included were those presenting for the first time with a new foot ulcer within a period of 12 months, either at the outpatient or inpatient clinics of participating centres. Excluded patients were those who had been treated at the participating centres for an ulcer on the ipsilateral foot during the previous 12 months and those with a life expectancy of less than 1 year. Participants attended follow-up visits on a monthly basis. At baseline and during all follow-up visits, data were collected and recorded on standardised case record forms. This was done by dedicated investigators in each centre who were trained during plenary meetings and on-site visits. Recorded data included demographics, data on co-morbidities and foot and ulcer characteristics, as well as management. The local ethics committees of the 14 hospitals approved the study protocol and all patients gave written informed consent.
Management of diabetic foot ulcer
All patients were treated according to protocols based on the International Consensus on the Diabetic Foot , which include off-loading, diagnosis and treatment of infection, assessment of vascular status, treatment of PAD and regular wound debridement.
Potential predictive factors
Potential determinants of healing were chosen on the basis of (1) current literature; (2) expert opinion after extensive discussions during EURODIALE meetings; and (3) suitability for use in daily clinical practice. In addition to sex, age at baseline and duration of diabetes, several disease-specific characteristics and co-morbidities were investigated .
All patients underwent a standardised examination according to the PEDIS system. This was developed by the International Consensus on the Diabetic Foot to enable classification of patients for clinical research purposes [11, 12] and classifies foot ulcers according to five categories: perfusion, extent, depth, infection and sensation.
Perfusion assessment included evaluation of the presence of pedal pulses and measurement of the ankle–brachial pressure index (ABPI) using a handheld Doppler device; PAD was considered to be present if ABPI was <0.9 and/or two foot pulses were absent.
Extent (i.e. size) was determined by multiplying the largest by the second largest diameter perpendicular to the first and divided into three categories: <1 cm2, 1–5 cm2 and >5 cm2.
Depth was described as either deep or superficial if a full thickness lesion of the skin was or was not extending through the subcutis, respectively.
Infection was diagnosed if two or more of the following signs were present: frank purulence, local warmth, erythema, lymphangitis, oedema, pain, fever and foul smell. The term infection covers both soft tissue infection and bone infection.
Evaluation of sensation (peripheral neuropathy [PNP]) included pressure sensation (10 g monofilament on plantar aspect of hallux, metatarsophalangeal joints 1 and 5), tactile sensation (cotton wisp on dorsum of foot), vibration sensation (128 Hz tuning fork on dorsum of the hallux) and blunt/sharp discrimination (dorsum of foot). PNP was diagnosed if the results of two or more of the aforementioned tests were abnormal.
In addition, the location of the ulcer was divided into plantar (on the plantar toes, plantar mid- or forefoot and plantar hind foot) and non-plantar (on the dorsal or interdigital part of the toes, on the dorsal or lateral aspect of the foot and heel ulcers). Ulcer duration was divided into three categories: <1 week, between 1 week and 3 months, and >3 months.
The following disabling co-morbidities were assessed: presence of severe visual impairment (defined as the inability to read a newspaper after correction), end-stage renal disease (ESRD) (defined as dependency on haemodialysis or peritoneal dialysis or a previous renal transplant procedure), heart failure (New York Heart Association [NYHA] classification III or IV), any neurological disorder (excluding diabetic polyneuropathy) resulting in loss of motor or sensory function (e.g. stroke) and inability to stand or walk without help.
Study main outcome
Main outcome was complete healing (with or without minor amputation) of the foot, within the maximum follow-up period of 1 year. Healing was defined as healing (intact skin) of the whole foot at two consecutive visits. If more than one ulcer was present, the foot was defined as healed once all ulcers were healed. Outcome information was not obtained in 144 patients (11.7% of the patients included) who dropped out of the study and were therefore excluded from the analyses. Reasons for dropout were non-compliance (n = 24), inability to follow the patient (lack of transportation, no social support, too sick to attend; n = 25) or if care had been taken over by other specialists (n = 29); in 66 patients the reason for dropout could not be discovered. At baseline these participants were slightly older and had a higher incidence of heart failure, deeper ulcers and ulcers of longer duration than those included in the analyses (n = 1,088; Table 1).
All statistical analyses were carried using the STATA software package version 9.2 (STATA, College Station, TX, USA). Comparisons between groups’ characteristics were made with χ 2 tests (frequency data) or Student’s t test (continuous data).
Multiple imputation of missing values of predictor variables
Values for one (n = 188), two (n = 35) or three (n = 13) predictor variables were not available for 236 participants; the number of missing values per predictor ranged from 0 to 6%. In order to decrease bias and increase power of the analyses , we used multiple imputation chained equations (procedure ‘ICE’ in STATA) to impute those missing values (1.7% of all required values) rather than performing complete case analyses [14, 15]. With ICE the imputation model of a single variable uses all the other variables as predictors by appropriate regression models (i.e. linear, logistic or multinomial if imputed variable is continuous, dichotomous or categorical). We generated five imputed datasets that were used to fit the regression models of interest (in each dataset and in the final, i.e. the combined dataset). Parameter estimates and standard errors were combined across the five replicates according to the procedure described by Rubin  and Carlin et al.  (procedure ‘micombine’ in STATA).
Development of predictive models
First, univariable logistic regression analyses were performed for all potential predictor variables with the outcome of interest (non-healing), with values presented as univariable odds ratios (ORs) along with the respective 95% CI. Second, all potential predictors were entered simultaneously in a multivariable logistic regression model that was reduced to a most parsimonious model using a backward selection method based on Akaike’s Information Criterion. These models yielded a set of variables that best predict (and can be regarded as independent predictors of) outcome.
Within the 1 year follow-up, 77% of the 1,088 patients healed, 12% were still undergoing treatment, 5% underwent a major (i.e. above the ankle level) amputation and 6% died (before healing of the foot ulcer). Among the patients who healed, 17% underwent a minor amputation; this rate was similar to that in those patients who did not heal (20%, p = 0.425).
When stratifying patients according to the presence or absence of PAD, significantly (p < 0.001) worse healing rates were observed in patients with than in those without PAD (69% vs 84%, respectively). Major amputation and mortality rates were also higher in patients with (8% and 9%, respectively) than in patients without PAD (2% and 3% respectively; p < 0.001). Baseline characteristics of patients with PAD compared with those without PAD are provided in Table 2.
Predictors of healing
Table 3 shows the univariable associations of the potential predictors of non-healing in the overall population and Table 4 presents the variables retained in the predictive models after backward selection in the combined imputed datasets. The estimates were similar to those obtained in the complete cases dataset (n = 854) indicating that missing values were non-selective (data not shown). These include the following eight characteristics, all of which predict lower probabilities of healing: older age, male sex, larger ulcer size, heart failure, inability to stand or walk without help, ESRD, PNP and PAD. These variables were consistently identified in all five imputed datasets.
Since we hypothesised that, from an aetiological point of view, predictors of non-healing would differ between patients with and those without PAD, predictive models were also fitted for these two groups separately (Table 4). In patients with PAD almost all of the predictors identified in the whole study population, with the exception of PNP, were again found to be independent predictors of healing. In addition, the presence of infection emerged as an additional independent predictor of non-healing. In patients without PAD, older age, larger ulcer size, inability to stand or walk without help, ESRD, PNP and, in addition, longer ulcer duration were independent predictors of poorer healing.
The observed interaction between infection and PAD status partly supports the classification of foot ulcer disease into four stages as suggested by Armstrong et al. (University of Texas classification system) . Accordingly, upon analysis of the odds of non-healing per PAD × infection status, it was only in those patients with both PAD and infection that the odds of non-healing were markedly increased compared with those without PAD or infection: OR 2.82, CI 1.88–4.22, p < 0.001 in unadjusted analyses (Fig. 1) vs OR 1.87, CI 1.20–2.91, p < 0.001 after adjustments for the other variables included in the predictive model.
The EURODIALE study is one of the few large prospective, international studies on outcome and determinants of outcome in diabetic foot disease. Despite the severity of the underlying disease and the important co-morbidity , clinical outcome of this population within a 1 year follow-up can be considered favourable. In our cohort, 77% of the patients healed (with or without a minor amputation), 5% underwent a major amputation and 6% died. However, healing rates in patients with PAD were considerably worse. In addition, predictors of healing also differed between the groups with and without PAD. The presence of infection, which is generally regarded as an important predictor of healing, was only predictive in individuals with PAD.
With regard to the overall outcome in our cohort, two recent studies found relatively comparable outcomes. Jeffcoate et al.  reported healing (excluding minor amputations) rates of 66% and an amputation rate of 5% with a similar prevalence of PAD. In a German cohort, Beckert et al.  found healing rates between 57% and 93% and major amputation rates of 3%, although the data as presented in that report cannot be easily compared because of their unique classification system. Oyibo et al.  also found similar rates of major amputation in their cohort (5%).
Our study shows that the combination of PAD and infection has a major impact on healing rates (Fig. 1); this significant interaction between PAD and infection is, in our opinion, one of the major findings of this study. In the patients without PAD we did not observe an association between infection and non-healing, which suggests that in these patients current antibiotic regimens and surgical techniques seem adequate to save a limb with adequate perfusion. However, within the total population of individuals with diabetic foot disease in developed countries, the group of infected and ischaemic ulcers accounted for almost one-third of all patients in our earlier report . In a recent study, a significant relation between PAD, infection and poor outcome was also observed: in that study’s large cohort of outpatients with type 2 diabetes, PAD was an independent predictor of infection-related mortality . Unfortunately, there is very little insight into the pathophysiology and treatment of infection in individuals with PAD. Currently it is not clear why infection is more prevalent and more difficult to treat in individuals with PAD. Remarkably, very few patients with PAD were included in most of the randomised trials on antibiotic therapy in diabetic foot infections [22, 23]. It has previously been demonstrated that lower limb tissue levels of antibiotics can be markedly decreased as a result of impaired perfusion in PAD . It is open to speculation whether aggressive revascularisation will improve control of infection in these patients.
Although some earlier studies have examined the impact of co-morbidities on ulcer healing , no studies, to our knowledge, have systematically assessed in a multivariable analysis the effects on ulcer healing of patient characteristics including co-morbidities, as well as foot and ulcer characteristics at baseline. In our study, older age, ulcer size and several co-morbidities were independent predictors of non-healing in patients with and without PAD. Recently a number of larger studies reported data on determinants of outcome in diabetic foot disease such as the single-centre study by Beckert in Germany and the UK multi-centre study initiated by Jeffcoate [19, 26]. The former focused on wound-based characteristics and also found that the presence of PAD (defined as absence of pedal pulses) was an independent predictor of outcome (healing), while infection was not. In the recent UK multi-centre study, ulcer area was a strong predictor of outcome, as was the presence of PAD; co-morbidities were not taken into account in the regression analyses. Surprisingly, depth of the ulcer was not associated with outcome in our multivariable model, a finding also shown by Ince et al. . In a retrospective study, Miyajima et al.  reported on patient characteristics that determined major lower extremity amputation and found that haemodialysis was an independent predictor of major amputation; in this study wound characteristics were not part of the regression analyses. The poor prognosis of foot ulcers for individuals in our study with ESRD is in line with earlier reports, in which amputation rates of 57% in individuals on haemodialysis were observed . Although in our study ESRD was a predictor of non-healing in patients with and without PAD, it seemed to have a particularly negative effect in the latter patient group. PAD is frequently diagnosed and associated with adverse outcomes in haemodialysis patients . PAD in ESRD patients is more severe and is accompanied by diffuse vascular calcifications, involvement of both distal infrapopliteal and foot arteries, and by impaired microcirculatory perfusion [29–31]. The severity of PAD in ESRD may explain the importance of ESRD in our healing models; additional mechanisms are probably impaired host defences in chronic renal failure and uraemia, or the presence of more resistant micro-organisms [32, 33].
The outcome of patients without PAD in our study was relatively favourable: 84% of the patients healed with or without minor amputation, 2% underwent a major amputation and 3% died. In our multivariate models, loss of sensation was associated with a poorer outcome in these patients, suggesting that loss of protective sensation is not only a key factor in the development of an ulcer, but also affects its outcome. This may be related to the preserved mechanism of off-loading the ulcer in individuals with intact protective sensation. However, neuropathy may also have direct effects on wound healing. Although data on the effect of neuropathy on wound healing in humans are scarce, some animal studies suggest that denervation may contribute to impaired wound healing in diabetes [34, 35]. A large dataset on individuals with neuropathic ulcers comes from retrospective database analyses in which healing rates of 47% were observed . Although this study reported on healing at 20 weeks (whereas the current one examined healing rates at 1 year), the different results compared with our study are striking and may be related to an increased awareness of the importance of adequate off-loading, as a result of publication of international guidelines and reports on casting techniques [37–39].
There are several limitations to our study. Individuals who were lost to follow-up were excluded from the analyses as healing status could not be obtained; these individuals were slightly older and had a greater incidence of heart failure, deep ulcers or ulcers with a longer duration and PAD at baseline. In addition, we excluded patients who had had a previous ulcer within 12 months prior to presentation (i.e. we probably excluded patients with recurrent ulcers). Also we excluded patients with a life expectancy shorter than 1 year because of anticipated problems with follow-up. The estimates obtained in our models may therefore have underestimated the probability of non-healing in patients with a recurrent foot ulcer, although in one earlier study healing rate of neuropathic foot ulcers did not decrease in patients with multiple recurrences . Since our study was embedded in daily clinical practice, limitations had to be set with regard to the number and type of data collected. It was therefore not possible to record more characteristics of these patients such as medication and extensive documentation of all complications. Moreover, to facilitate data collection, some continuous data (e.g. ulcer size) had to be transformed into a limited set of categories. Nevertheless, the set of potential predictors used in the present study do cover relevant patient and disease-specific aspects that can be easily assessed and used for patient risk estimation in clinical practice. Finally, our predictive model is based on outcomes that can be obtained in developed countries with access to the necessary resources such as antibiotic treatment and revascularisation; our results, therefore, are most relevant for diabetic foot ulcer patients in developed countries.
In conclusion, the results of this study have several implications. Both ulcer characteristics and several patient-related characteristics affected the outcome of diabetic foot ulcers. Therefore, a holistic approach by healthcare professionals who are familiar with the treatment of complicated diabetic patients is essential in order to identify the high-risk patient and start appropriate treatment. We found that patients with and without PAD differ in clinical characteristics, outcome and predictors of outcome. Taking into account these findings and the different pathophysiology and treatment of PAD and non-PAD ulcers, we feel that that diabetic foot ulcer with and without PAD should be defined as two separate disease states. The prevalent combination of PAD and infection is a unique entity; an important challenge lies in the development of evidence-based strategies to improve the poor outcome of these patients. Both studies comparing different antibiotic regimens in PAD, and studies evaluating the effects of early revascularisation on control of infection are urgently needed.
ankle–brachial pressure index
end-stage renal disease
New York Heart Association
peripheral arterial disease
Singh N, Armstrong DG, Lipsky BA (2005) Preventing foot ulcers in patients with diabetes. JAMA 293:217–228
Nabuurs-Franssen MH, Huijberts MS, Nieuwenhuijzen Kruseman AC, Willems J, Schaper NC (2005) Health-related quality of life of diabetic foot ulcer patients and their caregivers. Diabetologia 48:1906–1910
Apelqvist J, Ragnarson-Tennvall G, Larsson J, Persson U (1995) Long-term costs for foot ulcers in diabetic patients in a multidisciplinary setting. Foot Ankle Int 16:388–394
Apelqvist J, Ragnarson-Tennvall G, Persson U, Larsson J (1994) Diabetic foot ulcers in a multidisciplinary setting. An economic analysis of primary healing and healing with amputation. J Intern Med 235:463–471
Ragnarson-Tennvall G, Apelqvist J (2004) Health-economic consequences of diabetic foot lesions. Clin Infect Dis 39(Suppl 2):S132–S139
Apelqvist J, Bakker K, van Houtum WH, Nabuurs-Franssen MH, Schaper NC (2000) International consensus and practical guidelines on the management and the prevention of the diabetic foot. International Working Group on the Diabetic Foot. Diabetes Metab Res Rev 16(Suppl 1):S84–S92
Prompers L, Huijberts M, Apelqvist J et al (2007) High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale Study. Diabetologia 50:18–25
Boulton AJ (1996) The pathogenesis of diabetic foot problems: an overview. Diabet Med 13(Suppl 1):S12–S16
Armstrong DG, Lavery LA, Harkless LB (1998) Validation of a diabetic wound classification system. The contribution of depth, infection, and ischemia to risk of amputation. Diabetes Care 21:855–859
Prompers L, Huijberts M, Apelqvist J et al (2007) Optimal organisation of health care in diabetic foot disease. Introduction to the Eurodiale Study. Int J Low Extrem Wounds 6:11–17
Schaper NC, Apelqvist J, Bakker K (2003) The international consensus and practical guidelines on the management and prevention of the diabetic foot. Curr Diab Rep 3:475–479
Schaper NC (2004) Diabetic foot ulcer classification system for research purposes: a progress report on criteria for including patients in research studies. Diabetes Metab Res Rev 20(Suppl 1):S90–S95
Little R (1992) Regression with missing X’s: a review. J Am Stat Assoc 87:1227–1237
Royston P (2005) Multiple imputation of missing values: update of ice. Stata Journal 5:527–536
van Buuren S, Boshuizen HC, Knook DL (1999) Multiple imputation of missing blood pressure covariates in survival analysis. Stat Med 18:681–694
Rubin D (1987) Multiple imputation for nonresponse in surveys. Wiley, New York
Carlin J, Li N, Greenwood P, Coffey C (2003) Tools for analyzing multiple imputed datasets. Stata Journal 3:226–244
Jeffcoate WJ, Chipchase SY, Ince P, Game FL (2006) Assessing the outcome of the management of diabetic foot ulcers using ulcer-related and person-related measures. Diabetes Care 29:1784–1787
Beckert S, Witte M, Wicke C, Konigsrainer A, Coerper S (2006) A new wound-based severity score for diabetic foot ulcers: a prospective analysis of 1,000 patients. Diabetes Care 29:988–992
Oyibo SO, Jude EB, Tarawneh I et al (2001) The effects of ulcer size and site, patient’s age, sex and type and duration of diabetes on the outcome of diabetic foot ulcers. Diabet Med 18:133–138
Cardoso CR, Salles GF (2007) Macro and microvascular complications are determinants of increased infection-related mortality in Brazilian type 2 diabetes mellitus patients. Diabetes Res Clin Pract 75:51–58
Lipsky BA, Armstrong DG, Citron DM, Tice AD, Morgenstern DE, Abramson MA (2005) Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): prospective, randomised, controlled, double-blinded, multicentre trial. Lancet 366:1695–1703
Harkless L, Boghossian J, Pollak R et al (2005) An open-label, randomized study comparing efficacy and safety of intravenous piperacillin/tazobactam and ampicillin/sulbactam for infected diabetic foot ulcers. Surg Infect (Larchmt) 6:27–40
Raymakers JT, Houben AJ, van der Heyden JJ, Tordoir JH, Kitslaar PJ, Schaper NC (2001) The effect of diabetes and severe ischaemia on the penetration of ceftazidime into tissues of the limb. Diabet Med 18:229–234
Morbach S, Quante C, Ochs HR, Gaschler F, Pallast JM, Knevels U (2001) Increased risk of lower-extremity amputation among Caucasian diabetic patients on dialysis. Diabetes Care 24:1689–1690
Ince P, Kendrick D, Game F, Jeffcoate W (2007) The association between baseline characteristics and the outcome of foot lesions in a UK population with diabetes. Diabet Med 24:977–981
Miyajima S, Shirai A, Yamamoto S, Okada N, Matsushita T (2006) Risk factors for major limb amputations in diabetic foot gangrene patients. Diabetes Res Clin Pract 71:272–279
Rajagopalan S, Dellegrottaglie S, Furniss AL et al (2006) Peripheral arterial disease in patients with end-stage renal disease: observations from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Circulation 114:1914–1922
Boufi M, Ghaffari P, Allaire E, Fessi H, Ronco P, Vayssairat M (2006) Foot gangrene in patients with end-stage renal disease: a case control study. Angiology 57:355–361
Leskinen Y, Salenius JP, Lehtimaki T, Huhtala H, Saha H (2002) The prevalence of peripheral arterial disease and medial arterial calcification in patients with chronic renal failure: requirements for diagnostics. Am J Kidney Dis 40:472–479
Gensler SW, Haimovici H, Hoffert P, Steinman C, Beneventano TC (1965) Study of vascular lesions in diabetic, nondiabetic patients. Clinical, arteriographic, and surgical considerations. Arch Surg 91:617–622
Fejfarova V, Jirkovska A, Petkov V, Boucek P, Skibova J (2004) Comparison of microbial findings and resistance to antibiotics between transplant patients, patients on hemodialysis, and other patients with the diabetic foot. J Diabetes Complications 18:108–112
Cheung A, Wong L (2001) Surgical infections in patients with chronic renal failure. Infect Dis Clin North Am 15:775–796
Richards AM, Floyd DC, Terenghi G, McGrouther DA (1999) Cellular changes in denervated tissue during wound healing in a rat model. Br J Dermatol 140:1093–1099
Gibran NS, Jang YC, Isik FF et al (2002) Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus. J Surg Res 108:122–128
Margolis DJ, Allen-Taylor L, Hoffstad O, Berlin JA (2003) Diabetic neuropathic foot ulcers: predicting which ones will not heal. Am J Med 115:627–631
Armstrong DG, Lavery LA, Wu S, Boulton AJ (2005) Evaluation of removable and irremovable cast walkers in the healing of diabetic foot wounds: a randomized controlled trial. Diabetes Care 28:551–554
Mueller MJ, Diamond JE, Sinacore DR et al (1989) Total contact casting in treatment of diabetic plantar ulcers. Controlled clinical trial. Diabetes Care 12:384–388
Nabuurs-Franssen MH, Sleegers R, Huijberts MS et al (2005) Total contact casting of the diabetic foot in daily practice: a prospective follow-up study. Diabetes Care 28:243–247
Nabuurs-Franssen MH, Huijberts MS, Sleegers R, Schaper NC (2005) Casting of recurrent diabetic foot ulcers: effective and safe? Diabetes Care 28:1493–1494
The project Optimal Organization of Health Care in Diabetic Foot Disease is funded by the European Commission as part of the fifth framework programme (QLG4-CT-2002-1524) and was supported by an unrestricted educational grant from Smith and Nephew. Neither of these parties was involved in design and conduct of the study; collection, management, analysis and interpretation of the data; and preparation, review or approval of the manuscript. We would like to thank all EURODIALE co-workers: M. Annersten, R. Bem, A. Boykowskov, H. Brill, S. Bus, A. De Leiva, J. De Neve, S. Di Cario, V. Fejfarova, J. Gaitan, D. Geenen, T. Geens, J. Gibbons, L. Giurato, B. Hempe, M. Hutten, J. Kersken, F. Palumbo, L. Rizzo, R. Roel, D. Simon and M. Slak.
Duality of interest
The authors declare that there is no duality of interest associated with this manuscript.
This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
About this article
Cite this article
Prompers, L., Schaper, N., Apelqvist, J. et al. Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study. Diabetologia 51, 747–755 (2008). https://doi.org/10.1007/s00125-008-0940-0
- Foot ulcer
- Peripheral arterial disease
- Predictive model