Diabetic encephalopathy: a concept in need of a definition
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KeywordsCognitive Decline Cognitive Dysfunction Dentate Nucleus Descriptive Definition Cognitive Complaint
Research criteria for diabetes-associated cognitive decline (DACD)
Lowered performance by a patient with established type 1diabetes mellitus (below − 1.5 SD, compared to age- andeducationally matched control subjects) on validated neuropsychologicaltests in one or more of the following cognitivedomains:
•visual perception [3, 9].
2. Cognitive deficits are determined as chronic, i.e. not related toacute hypo- or hyperglycaemia.
3. Usually, but not necessarily accompanied by subjective cognitive complaints.
4. Not meeting criteria for dementia, and excluding other likelycauses e.g. head trauma, intoxication, alcohol abuse, Parkinson’sdisease, multiple sclerosis, stroke and other primary brain diseases.
We hope that by offering this simple descriptive definition, research into the pathogenesis, consequences and potential therapeutic interventions of DACD will be stimulated. In addition, the extent to which diabetes-related cognitive decline affects day-to-day functioning and diabetes self-care needs to be assessed, to further expand our understanding of the clinical implications of this potentially burdensome complication. The reliability of this assessment is fully dependent on the accuracy of the diagnostic tests.
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