Comment to: Patti ME, Mcmahon G, Mun EC et al. (2005) Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia 48:2236–2240
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glucagon-like peptide 1
To the Editor:
We read the recent report of three cases of hypoglycaemia following gastric bypass surgery with interest . Consistent with a prior study , the authors report postprandial hypoglycaemia in a subgroup of patients who had undergone gastric bypass surgery for morbid obesity. The authors speculate that ‘excessive secretion of GLP-1 played a pivotal role in post-gastric bypass hypoglycaemia in our second and third patients, and perhaps in the first.’ However, respectfully we suggest that the report contains insufficient evidence to support this intriguing conclusion.
The arguments provided by the authors in support of this conclusion are as follows: (1) two out of the three patients exhibited increased (∼300 pmol/l) postprandial glucagon-like peptide 1 (GLP-1) plasma levels; (2) pancreatic sections from all three patients showed islets adjacent to exocrine ducts as well as single hormone-positive cells inside the ductal epithelium; (3) in one patient the frequency of Ki-67-positive cells appeared higher in exocrine ducts; and. (4) the relative beta-cell area in one of the patients was reported to be relatively high (3.3%) compared with that in obese controls.
We respectfully suggest caution before concluding that the data provided indicate a new clinical syndrome of postprandial hypoglycaemia due to expansion of beta cell mass secondary to excessive GLP-1 secretion. There is no reason to expect a high beta cell mass to cause hypoglycaemia in response to physiological stimuli, especially if GLP-1 is thought to be involved, which only stimulates insulin secretion in a strictly glucose-dependent manner . In fact, the glucose-sensing machinery of pancreatic beta cells represents a potent safeguard against excessive insulin secretion . Moreover, islet or beta cell hyperplasia would more likely be associated with autonomous insulin secretion, leading to fasting rather than postprandial hypoglycaemia. The report by Patti et al. also contains no information on whether accelerated gastric emptying (of the residual stomach) was present in the patients with postprandial hypoglycaemia compared with asymptomatic patients following gastric bypass . Accelerated gastric emptying might be expected in the classic late dumping syndrome . Perhaps abnormal counter-regulation to hypoglycaemia should be excluded as an alternative explanation for the symptomatic hypoglycaemia. Finally, perhaps the greatest argument against the conclusion that these symptoms were due to increased beta cell mass is the fact that an 80% pancreatectomy in case one provided no relief, and a distal pancreateomy in case two provided only temporary relief of symptoms .
We certainly appreciate the dangerous nature of hypoglycaemia and note that two of the patients were involved in road traffic accidents attributed to hypoglycaemia. Indeed, one lesson is that in cases with recurrent unresolved hypoglycaemia, driving a motor vehicle is ill advised. None the less, the long-term clinical success of the surgical intervention selected for these patients needs to be critically assessed before this putative novel syndrome and its therapy can be accepted and pancreatic resections advised for patients presenting with reactive hypoglycaemia after bariatric surgery.
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