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Diabetologia

, Volume 45, Issue 10, pp 1372–1378 | Cite as

Circulating concentrations of asymmetrical dimethyl-L-arginine are increased in women with previous gestational diabetes

  •  F. Mittermayer
  •  B. Mayer
  •  A. Meyer
  •  C. Winzer
  •  G. Pacini
  •  O. Wagner
  •  M. Wolzt
  •  A. Kautzky-Willer
Article

Abstract

Aims/hypothesis. The concentration of asymmetrical dimethyl-L-arginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, is increased in patients at risk or with cardiovascular disease. We have investigated ADMA concentrations in women with a history of gestational diabetes (GDM), who could develop endothelial dysfunction and Type II (non-insulin-dependent) diabetes mellitus after delivery, and in healthy control subjects.

Methods. Previous GDM patients were grouped according to their BMI as obese (≥25 kg/m2, n=46) or non-adipose (<25 kg/m2, n=31). Serum samples were taken 14 to 16 weeks after delivery and after 1 year. The control group comprised 17 healthy women (BMI<25 kg/m2). ADMA concentrations were analysed by high performance liquid chromatography.

Results. ADMA concentrations were comparable between obese and non-adipose GDM patients (0.58±0.02 and 0.57±0.02 µmol/l, respectively), and higher than in the control group (0.47±0.03 µmol/l; p<0.006). Insulin resistance as estimated by the insulin sensitivity index was more frequent among the obese than the non-adipose GDM women (p<0.05) and control subjects (p<0.05, both). No change in ADMA concentrations was found after 1 year in women with GDM. There was only a slight correlation between ADMA and BMI (r=0.26, p<0.02), triglycerides (r=0.29, p<0.004), or fasting plasma glucose (r=0.21, p<0.05), and not with the insulin sensitivity index or other parameters. In a multiple regression analysis ADMA serum concentrations were only associated with triglycerides.

Conclusion/interpretation. Circulating ADMA concentrations are increased in normoglycaemic women with previous GDM. This increase is independent from other risk factors or surrogate markers for diabetes or cardiovascular events.

Gestational diabetes asymmetrical dimetylarginine nitric oxide insulin resistance cholesterol 

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  •  F. Mittermayer
    • 2
  •  B. Mayer
    • 2
  •  A. Meyer
    • 2
  •  C. Winzer
    • 3
  •  G. Pacini
    • 5
  •  O. Wagner
    • 4
  •  M. Wolzt
    • 1
  •  A. Kautzky-Willer
    • 3
  1. 1.Department of Clinical Pharmacology, Allgemeines Krankenhaus Wien, Währinger Gürtel 18–20, 1090 Vienna, Austria
  2. 2.Department of Clinical Pharmacology, University of Vienna, Vienna, Austria
  3. 3.Department of Internal Medicine III, University of Vienna, Vienna, Austria
  4. 4.Clinical Institute for Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria
  5. 5.Institute of Systems Science and Biomedical Engineering (LADSEB-CNR), Padova, Italy

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