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Diabetologia

, Volume 45, Issue 7, pp 1045–1047 | Cite as

Beta-cell differentiation during human development does not rely on nestin-positive precursors: implications for stem cell-derived replacement therapy

  • K. Piper
  • S. G. Ball
  • L. W. Turnpenny
  • S. Brickwood
  • D. I. Wilson
  • N. A. Hanley
Letters Observations

Keywords

Mouse Embryonic Stem Cell Nestin Expression Foetal Pancreas Ependymal Layer Pancreatic Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292:1389–1394PubMedCrossRefGoogle Scholar
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    Zulewski H, Abraham EJ, Gerlach MJ et al. (2001) Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50:521–533PubMedCrossRefGoogle Scholar
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    Hanley NA, Ball SG, Clement-Jones M et al. (1999) Expression of steroidogenic factor 1 and Wilms’ tumour 1 during early human gonadal development and sex determination. Mech Dev 87:175–180Google Scholar
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    Wroblewski J, Engstrom M, Edwall-Arvidsson C, Sjoberg G, Sejersen T, Lendahl U (1997) Distribution of nestin in the developing mouse limb bud in vivo and in micro-mass cultures of cells isolated from limb buds. Differentiation 61:151–159PubMedCrossRefGoogle Scholar
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    Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P (2000) Early pattern of differentiation in the human pancreas. Diabetes 49:225–232PubMedCrossRefGoogle Scholar
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    Lendahl U, Zimmerman LB, McKay RD (1990) CNS stem cells express a new class of intermediate filament protein. Cell 60:585–595PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • K. Piper
    • 1
  • S. G. Ball
    • 1
  • L. W. Turnpenny
    • 1
  • S. Brickwood
    • 1
  • D. I. Wilson
    • 1
  • N. A. Hanley
    • 2
  1. 1.Division of Human GeneticsSouthampton University, Southampton General HospitalSouthamptonUK
  2. 2.School of Clinical Medical SciencesNewcastle UniversityNewcastle upon TyneUK

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