Diabetologia

, Volume 45, Issue 5, pp 711–718

Family histories of Type II diabetes and hypertension predict intima–media thickness in patients with Type I diabetes

  • S. Mäkimattila
  • K. Ylitalo
  • A. Schlenzka
  • M.-R. Taskinen
  • P. Summanen
  • M. Syvänne
  • H. Yki-Järvinen
Article

Abstract

Aims/hypothesis. Hyperglycaemia predicts microvascular complications but data on macrovascular disease are limited. We searched for predictors of carotid artery intima–media thickness in young adults with Type I (insulin-dependent) diabetes mellitus.

Methods. A total of 71 children (F/M = 34/37) were followed after their diagnosis until they reached 32 ± 1 years of age, when duration of diabetes averaged 22 ± 1 years. Cardiovascular risk markers [lipids, blood pressure, smoking, urinary albumin excretion rate, lifetime glycaemic exposure (A1c months), exercise habits, alcohol consumption, family history] were evaluated at age 21 ± 1 for the baseline examination and at age 32 ± 1 years for the follow-up examination years. During follow-up, intima–media thickness of common and internal carotid arteries and the carotid bulb were quantitated using a high-resolution B-mode ultrasound.

Results. In univariate analysis, age, BMI, blood pressure, lifetime glycaemic exposure, a positive family history of Type II (non-insulin-dependent) diabetes mellitus, hypertension and cardiovascular disease were predictors of carotid intima–media thickness. In multivariate analysis, a positive family history of Type II diabetes predicted maximal (p < 0.05) and common (p < 0.005) carotid artery intima–media thickness, family history of hypertension predicted increases in maximal (p < 0.04), and far wall (p < 0.006) carotid artery intima–media thickness, and lifetime glycaemic exposure was an independent predictor of increased carotid bulb thickness (p < 0.03).

Conclusion/interpretation. Positive family histories of Type II diabetes and hypertension are independent predictors of carotid intima–media thickness in patients with Type I diabetes, and could therefore predispose these patients to atherosclerosis

Atherosclerosis cardiovascular risk glucose ultrasound 

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • S. Mäkimattila
    • 1
  • K. Ylitalo
    • 2
  • A. Schlenzka
    • 1
  • M.-R. Taskinen
    • 2
  • P. Summanen
    • 3
  • M. Syvänne
    • 2
  • H. Yki-Järvinen
    • 1
  1. 1.University of Helsinki, Department of Medicine, Division of Diabetes, P.O. Box 340, 00029 HUCH, HelsinkiFinland
  2. 2.Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, HelsinkiFinland
  3. 3.Department of Medicine, Division of Ophthalmology, Helsinki University Central Hospital, HelsinkiFinland

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