Theoretical and Applied Genetics

, Volume 121, Issue 6, pp 1103–1116 | Cite as

Syntenic relationships among legumes revealed using a gene-based genetic linkage map of common bean (Phaseolus vulgaris L.)

  • Melody McConnell
  • Sujan Mamidi
  • Rian Lee
  • Shireen Chikara
  • Monica Rossi
  • Roberto Papa
  • Phillip McCleanEmail author
Original Paper


Molecular linkage maps are an important tool for gene discovery and cloning, crop improvement, further genetic studies, studies on diversity and evolutionary history, and cross-species comparisons. Linkage maps differ in both the type of marker and type of population used. In this study, gene-based markers were used for mapping in a recombinant inbred (RI) population of Phaseolus vulgaris L. P. vulgaris, common dry bean, is an important food source, economic product, and model organism for the legumes. Gene-based markers were developed that corresponded to genes controlling mutant phenotypes in Arabidopsis thaliana, genes undergoing selection during domestication in maize, and genes that function in a biochemical pathway in A. thaliana. Sequence information, including introns and 3′ UTR, was generated for over 550 genes in the two genotypes of P. vulgaris. Over 1,800 single nucleotide polymorphisms and indels were found, 300 of which were screened in the RI population. The resulting LOD 2.0 map is 1,545 cM in length and consists of 275 gene-based and previously mapped core markers. An additional 153 markers that mapped at LOD <1.0 were placed in genetic bins. By screening the parents of other mapping populations, it was determined that the markers were useful for other common Mesoamerican × Andean mapping populations. The location of the mapped genes relative to their homologs in Arabidopsis thaliana (At), Medicago truncatula (Mt), and Lotus japonicus (Lj) were determine by using a tblastx analysis with the current pseduochromosome builds for each of the species. While only short blocks of synteny were observed with At, large-scale macrosyntenic blocks were observed with Mt and Lj. By using Mt and Lj as bridging species, the syntenic relationship between the common bean and peanut was inferred.


Linkage Group Common Bean Recombinant Inbred Syntenic Block Nonsynonymous SNPs 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This project was funded by the USDA Cooperative State Research, Education and Extension Service: National Research Initiative, Plant Genome Program. We would also like to thank Dr. Paul Gepts for supplying us with genotype information on the markers from the core BAT93 × Jalo EEP558 RI linkage map.

Supplementary material

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Supplementary Table 1 (XLS 77 kb)
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Supplementary Table 2 (XLS 126 kb)
122_2010_1375_MOESM3_ESM.pdf (89 kb)
Supplementary Table 3 (PDF 89 kb)
122_2010_1375_MOESM4_ESM.pdf (103 kb)
Supplementary Table 4 (PDF 102 kb)


  1. Altschul SF, Madden TL, Schäffer AA, Zhang J, Zhang Z (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389CrossRefPubMedGoogle Scholar
  2. American Dietetic Association (2004) Position of the American Dietetic Association and Dietitians of Canada. Nutrition intervention in the care of persons with the human immunodeficiency virus infection. J Am Diet Assoc 104:1425–1441CrossRefGoogle Scholar
  3. Arabidopsis Genome Initiative (2000) Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408:796–815CrossRefGoogle Scholar
  4. Aubert G, Morin J, Jacquin F, Loridon K, Quillet MC, Petit A, Rameau C, Lejune-Henaut I, Huguet T, Burstin J (2006) Functional mapping in pea, as an aid to the candidate gene selection and for investigating synteny with the model legume Medicago truncatula. Theor Appl Genet 112:1024–1041CrossRefPubMedGoogle Scholar
  5. Becerra-Velasquez VL, Gepts P (1994) RFLP diversity of common bean (Phaseolus vulgaris) in its centres of origin. Genome 37:256–263CrossRefGoogle Scholar
  6. Bertioli DJ, Moretzsohn MC, Madsen LH, Leal-Bertioli SCM, Guimaraes PM, Hougaard BK, Fredslund J, Nielsen AM, Sato S, Tabata S, Cannon SB, Stougaard J (2009) An analysis of synteny of Arachis with Lotus and Medicago sheds new light on the structure, stability and evolution of legume genomes. BMC Genomics 10:45CrossRefPubMedGoogle Scholar
  7. Blanc G, Wolfe KH (2004) Widespread paleopolyploidy in model plant species inferred from age distributions of duplicate genes. Plant Cell 16:1667–1678CrossRefPubMedGoogle Scholar
  8. Bowers JE, Chapman BA, Rong J, Paterson AM (2003) Unravelling angiosperm evolution by phylogenetic analysis of chromosomal duplication events. Nature 422:433–438CrossRefPubMedGoogle Scholar
  9. Brady L, Basset MJ, McClean PE (1998) Molecular markers associated with T and Z, two genes controlling partly colored seed coat patterns in common bean. Crop Sci 38:1073–1075CrossRefGoogle Scholar
  10. Buys H, Hendricks M, Eley B, Hussey G (2002) The role of nutrition and micronutrients in pediatric HIV infection. SADJ 57:454–456PubMedGoogle Scholar
  11. Ching A, Caldwell KS, Jung M, Dolan M, Smith OS, Tingey S, Morgante M, Rafalski AJ (2002) SNP frequency, haplotype structure and linkage disequilibrium in elite maize inbred lines. BMC Genetics 3:19CrossRefPubMedGoogle Scholar
  12. Choi HK, Mun JH, Kim DJ, Zhu H, Baek JM, Mudge J, Roe B, Ellis N, Doyle J, Kiss GB, Young ND, Cook DR (2004) Estimating genome conservation between crop and model legume species. Proc Natl Acad Sci USA 101:15289–15294CrossRefPubMedGoogle Scholar
  13. Choi I-Y, Hyten DL, Matukumalli LK, Song Q, Chaky JM, Quigley CV, Chase K, Lark KG, Reiter RS, Yoon M-S, Hwang E-Y, Yi S-I, Young ND, Shoemaker RC, van Tassell CP, Specht JE, Cregan PB (2007) A soybean transcript map: gene distribution, haplotype and single-nucleotide polymorphism analysis. Genetics 176:685–696CrossRefPubMedGoogle Scholar
  14. Doyle JJ, Doyle JL (1987) A rapid DNA extraction procedure for small quantities of fresh leaf material. Phytochem Bulletin 19:11–15Google Scholar
  15. Drenkard E, Richter BG, Rozen S, Stutius LM, Angell NA, Mindrinos M, Cho RJ, Oefner PJ, Davis RW, Ausubel FM (2000) A simple procedure for the analysis of single nucleotide polymorphisms facilitates map-based cloning in Arabidopsis. Plant Phys 124:1483–1492CrossRefGoogle Scholar
  16. Flint-Garcia SA, Thornsberry JM, Buckler ES (2003) Structure of linkage disequilibrium in plants. Annu Rev Plant Biol 54:357–374CrossRefPubMedGoogle Scholar
  17. Freyre R, Skroch PW, Geffroy V, Adam-Blondon AF, Shirmohamadali A, Johnson WC, Llaca V, Nodari RO, Pereira PA, Tsai SM, Tohme J, Dron M, Nienhuis J, Vallejos CE, Gepts P (1998) Towards an integrated linkage map of common bean. 4. Development of a core linkage map and alignment of RFLP maps. Theor Appl Genet 97:847–856CrossRefGoogle Scholar
  18. Gao LF, Jing RL, Huo NX, Li Y, Li XP, Zhou RH, Chang XP, Tang JF, Ma ZY, Jia JZ (2004) One hundred and one new microsatellite loci derived from ESTs (EST-SSRs) in bread wheat. Theor Appl Genet 108:1392–1400CrossRefPubMedGoogle Scholar
  19. Gepts P (1998) Origin and evolution of common bean: past events and recent trends. HortScience 33:1124–1130Google Scholar
  20. Gepts P, Debouck DG (1991) Origin, domestication, and evolution of the common bean (Phaseolus vulgaris L.). In: Voysest O, Van Schoonhoven A (eds) Common beans: research for crop improvement. CAB Intern, Wallingford, OxonGoogle Scholar
  21. Gillespie S, Kadiyala S (2005) HIV/AIDS and food nutrition and security: from evidence to action. International Food Policy Research Institute, Washington, DCGoogle Scholar
  22. Grant D, Cregan P, Shoemaker RC (2000) Genome organization in dicots: genome duplication in Arabidopsis and synteny between soybean and Arabidopsis. Proc Natl Acad Sci USA 97:4168–4173CrossRefPubMedGoogle Scholar
  23. Hougaard BK, Madsen LH, Sandal N, de Carvalho Moretzsohn M, Fredslund J, Schauser L, Nielsen AM, Rohde T, Sato S, Tabata S, Bertioli DJ, Stougaard J (2008) Legume anchor markers link syntenic regions between Phaseolus vulgaris, Lotus japonicus, Medicago truncatula, and Arachis. Genetics 179:2299–2312CrossRefPubMedGoogle Scholar
  24. International Rice Genome Sequencing Project (2005) The map-based sequence of the rice genome. Nature 436:793–800CrossRefGoogle Scholar
  25. Kaplan L, Lynch TF (1999) Phaseolus (Fabaceae) in archeology: AMS radiocarbon dates and their significance for pre-Colombian agriculture. Econ Bot 53:261–272Google Scholar
  26. Kelly JD, Vallejos VA (2004) A comprehensive review of the major genes conditioning resistance to anthracnose in common bean. HortScience 39:1196–1207Google Scholar
  27. Kelly JD, Gepts P, Miklas PN, Coyne DP (2003) Tagging and mapping of genes and QTL and molecular-marker assisted selection for traits of economic importance in bean and cowpea. Field Crops Res 82:135–154CrossRefGoogle Scholar
  28. Kevei Z, Seres A, Kerest A, Kao P, Kiss P, Toth G, Endre G, Kiss GB (2005) Significant microsynteny with new evolutionary highlights is detected between Arabidopsis and legume model plants despite the lack of macrosynteny. Mol Gen Genomics 274:644–657CrossRefGoogle Scholar
  29. Koinange EMK, Singh SP, Gepts P (1996) Genetic control of the domestication syndrome in common bean. Crop Sci 36:1037–1045CrossRefGoogle Scholar
  30. Kolkman JM, Kelly JD (2003) QTL conferring resistance and avoidance to white mold in common bean. Crop Sci 43:539–548CrossRefGoogle Scholar
  31. Komulainen P, Brown GR, Mikknoen M, Karhu A, Garcia-Gil MR, O’Malley D, Lee B, Neale DB, Savolainen O (2003) Comparing EST-based genetic maps between Pinus sylvestris and Pinus taeda. Theor Appl Genet 107:667–678CrossRefPubMedGoogle Scholar
  32. Konieczny A, Ausubel FM (1993) A procedure for mapping Arabidopsis mutations using co-dominant ecotype-specific PCR-based markers. Plant J 4:403–410CrossRefPubMedGoogle Scholar
  33. Kruzich LA, Marquis GS, Carriquiry AL, Wilson CM, Stephensen CB (2004) US youths in the early stages of HIV disease have low intakes of some micronutrients important for optimal immune function. J Am Diet Assoc 104:1095–1101CrossRefPubMedGoogle Scholar
  34. Kwak M, Gepts P (2009) Structure of genetic diversity in the two major gene pools of common bean (Phaseolus vulgaris L., Fabaceae). Theor Appl Genet 118:979–992CrossRefPubMedGoogle Scholar
  35. Lai Z, Livingstone K, Zou Y, Church A, Knapp SJ, Andrews J, Rieseberg LH (2005) Identification and mapping of SNPs from ESTs in sunflower. Theor Appl Genet 111:1532–1544CrossRefPubMedGoogle Scholar
  36. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, Newberg LA (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1:174–181CrossRefPubMedGoogle Scholar
  37. Liu K, Muse SV (2005) PowerMarker: an integrated analysis environment for genetic marker analysis. Bioinformatics 21:2128–2129CrossRefPubMedGoogle Scholar
  38. López CE, Acosta IF, Jara C, Pedraza F, Gaitán-Solís E, Gallego G, Beebe S, Tohme J (2003) Identifying resistance gene analogs associated with resistances to different pathogens in common bean. Phytopathology 93:88–95CrossRefPubMedGoogle Scholar
  39. McClean PE, Lee RK (2007) Genetic architecture of chalcone isomerase non-coding regions in common bean (Phaseolus vulgaris L.) Genome 50:203–214Google Scholar
  40. McClean PE, Lee RK, Otto C, Gepts P, Bassett MJ (2002) Molecular and phenotypic mapping of genes controlling seed coat pattern and color in common bean (Phaseolus vulgaris L.). J Hered 93:148–152CrossRefPubMedGoogle Scholar
  41. McClean PE, Lee RK, Miklas PM (2004) Sequence diversity analysis of dihydroflavonol 4-reductase intron 1 in common bean. Genome 47:266–280CrossRefPubMedGoogle Scholar
  42. McClean PE, Lavin M, Gepts P, Jackson SA (2008) Phaseolus vulgaris L.: a diploid model for soybean. In: Stacey G (ed) Genomics of soybean. Springer Science + Business Media, LLC, New York, pp 55–76CrossRefGoogle Scholar
  43. Meinke DW, Meinke LK, Showalter TC, Schissel AM, Mueller LA, Tzafrir I (2003) A sequence-based map of Arabidopsis genes with mutant phenotypes. Plant Physiol 131:409–418CrossRefPubMedGoogle Scholar
  44. Miklas PN, Stone V, Daly MJ, Stavely JR, Steadman JR, Bassett MJ, Delorme R, Beaver JS (2000) Bacterial, fungal, and viral disease resistance loci mapped in a recombinant inbred common bean population (‘Dorado’/XAN 176). J Am Soc HortSci 125:476–481Google Scholar
  45. Miklas PN, Johnson WC, Delorme R, Riley RH, Gepts P (2001) Inheritance and QTL analysis of physiological resistance to white mold in common bean G122. Crop Sci 41:309–315CrossRefGoogle Scholar
  46. Miklas PN, Delorme R, Riley RH (2003) Identification of QTL conditioning resistance to white mold in a snap bean population. J Am Soc HortSci 128:564–570Google Scholar
  47. Mudge J, Cannon SB, Kalo P, Oldroyd GED, Roe BA, Town CD, Young ND (2005) Highly syntenic regions in the genomes of soybean, Medicago truncatula, and Arabidopsis thaliana. BMC Plant Biol 5:15CrossRefPubMedGoogle Scholar
  48. Murray JD, Michaels TE, Cardona C, Schaafsma AW, Pauls KP (2004) Quantitative trait loci for leafhopper (Empoascafabe and Empoascakraemeri) resistance and seed weight in common bean. Plant Breed 123:474–479CrossRefGoogle Scholar
  49. Neff MM, Turk E, Kalishman M (2002) Web-based primer design for single nucleotide polymorphism analysis. Trends Genet 18:613–615CrossRefPubMedGoogle Scholar
  50. Nodari RO, Tsai SM, Gilbertson RL, Gepts P (1993a) Towards an integrated linkage map of common bean. 2. Development of an RFLP-based linkage map. Theor Appl Genet 85:513–520CrossRefGoogle Scholar
  51. Nodari RO, Tsai SM, Guzman P, Gilbertson RL, Gepts P (1993b) Towards an integrated linkage map of common bean III: Mapping genetic factors controlling host–bacteria interactions. Genetics 134:341–350PubMedGoogle Scholar
  52. Papa R, Acosta J, Delgado-Salinas A, Gepts P (2005) A genome-wide analysis of differentiation between wild and domesticated Phaseolus vulgaris from Mesoamerica. Theor Appl Genet 111:1147–1158CrossRefPubMedGoogle Scholar
  53. Papa R, Bellucci E, Rossi M, Leonardi S, Rau D, Gepts P, Nanni L et al (2007) Tagging the signatures of domestication in common bean (Phaseolus vulgaris) by means of pooled DNA samples. Ann Bot 100:1039–1051CrossRefPubMedGoogle Scholar
  54. Park SO, Coyne DP, Steadman JR, Skroch PW (2001) Mapping of QTL for resistance to white mold diseases in common bean. Crop Sci 41:1253–1262CrossRefGoogle Scholar
  55. Parkin IAP, Gulden SM, Sharpe AG, Lukens L, Trick M, Osborn TC, Lydiate DJ (2005) Segmental structure of the Brassica napus genome based on comparative analysis with Arabidopsis thaliana. Genetics 171:765–781CrossRefPubMedGoogle Scholar
  56. Pedrosa-Harand A, Porch T, Gepts P (2008) Standard nomenclature or common bean chromosomes and linkage groups. Annu Rept Bean Improv Coop 51:106–107Google Scholar
  57. Piperno DR, Dilehay TD (2008) Starch grains on human teeth reveal early broad crop diet in northern Peru. Proc Natl Acad Sci USA 105:19622–19627Google Scholar
  58. Ramirez M, Graham MA, Blanco-Lopez L, Silvente S, Medrano-Soto A, Blair MW, Hernandez G, Vance CP, Lara M (2005) Sequencing and analysis of common bean ESTs. Building a foundation for functional genomics. Plant Physiol 137:1211–1227CrossRefPubMedGoogle Scholar
  59. Remington DL, Thornsberry JM, Matsuoka Y, Wilson LM, Whitt SR, Doebley J, Kresovich S, Goodman MM, Buckler ES (2001) Structure of linkage disequilibrium and phenotypic associations in the maize genome. Proc Natl Acad Sci USA 98:11479–11484CrossRefPubMedGoogle Scholar
  60. Román-Avilés B, Kelly JD (2005) Identification of QTL conditioning resistance to Fusarium root rot in Phaseolus vulgaris L. Crop Sci 45:1881–1890CrossRefGoogle Scholar
  61. Rossi M, Bitocchi E, Bellucci E, Nanni L, Rau D, Attene G, Papa P (2009) Linkage disequilibrium and population structure in wild and domesticated populations of Phaseolus vulgaris L. Evol Appl (online) doi: 10.1111/j.1752-4571.2009.00082.x
  62. Rozen S, Skaletsky H (2000) Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S (eds) Bioinformatics methods and protocols: methods in molecular biology. Humana Press, Totowa, pp 365–386Google Scholar
  63. SAS Institute (1999) The SAS system for windows, version 9.13. SAS Institute, CaryGoogle Scholar
  64. Savarino A, Pescarmona GP, Boelaert JR (1999) Iron metabolism and HIV infection: reciprocal interactions with potentially harmful consequences? Cell Biochem Funct 17:279–287CrossRefPubMedGoogle Scholar
  65. Schlueter JA, Dixon P, Granger C, Grant D, Clark L, Doyle JJ, Shoemaker RC (2004) Mining EST databases to resolve evolutionary events in major crop species. Genome 47:868–876CrossRefPubMedGoogle Scholar
  66. Schmutz J, Cannon SB, Schlueter J, Ma J, Mitros T, Nelson W, Hyten DL, Song Q, Thelen JJ, Cheng J, Xu D, Hellsten U, May GD, Yu Y, Sakurai T, Umezawa T, Bhattacharyya MK, Sandhu D, Valliyodan B, Lindquist E, Peto M, Grant D, Shu S, Goodstein D, Barry K, Futrell-Griggs M, Abernathy B, Du J, Tian Z, Zhu L, Gill N, Joshi T, Libault M, Sethuraman A, Zhang XC, Shinozaki K, Nguyen HT, Wing RA, Cregan P, Specht J, Grimwood J, Rokhsar D, Stacey G, Shoemaker RC, Jackson SA (2010) Genome sequence of the palaeopolyploid soybean. Nature 463:178–183CrossRefPubMedGoogle Scholar
  67. Schneider KA, Grafton KF, Kelly JD (2001) QTL analysis of resistance to Fusarium root rot in bean. Crop Sci 41:535–542CrossRefGoogle Scholar
  68. Simillion C, Vandepoele K, Van Montagu MC, Van de Peer Y (2002) The hidden duplication past of Arabidopsis thaliana. Proc Natl Acad Sci USA 99:13627–13632CrossRefPubMedGoogle Scholar
  69. Singh SP (2001) Broadening the genetic base of common bean cultivars: a review. Crop Sci 41:1659–1675CrossRefGoogle Scholar
  70. Song QJ, Marek LF, Shoemaker RC, Lark KG, Concibido VC, Delannay X, Specht JE, Cregan PB (2004) A new integrated genetic linkage map of the soybean. Theor Appl Genet 109:122–128CrossRefPubMedGoogle Scholar
  71. South Africa Department of Health (2001) South African national guidelines on nutrition for people living with TB, HIV/AIDS and other debilitating diseases. Ministry of Health, Pretoria, South Africa. (accessed 1/26/2007)
  72. Staden R (1996) The Staden sequence analysis package. Mol Biotechnol 5:233–241CrossRefPubMedGoogle Scholar
  73. Tar’an B, Michaels TE, Pauls KP (2001) Mapping genetic factors affecting the reaction to Xanthomonas axonopodis pv phaseoli in Phaseolus vulgaris L. under field conditions. Genome 44:1046–1056CrossRefGoogle Scholar
  74. Tohme J, Orlando Gonzalez D, Beebe S, Duque MC (1996) AFLP analysis of gene pools of a wild bean core collection. Crop Sci 36:1375–1384CrossRefGoogle Scholar
  75. Vallejos CE, Sakiyama NS, Chase CD (1992) A molecular marker-based linkage map of Phaseolus vulgaris L. Genetics 131:733–740PubMedGoogle Scholar
  76. Vigoroux Y, McMullen M, Hittinger CT, Houchins K, Schulz L, Kresovich S, Matsuoka Y, Doebley J (2002) Identifying genes of agronomic importance in maize by screening microsatellites for evidence of selection during domestication. Proc Natl Acad Sci USA 99:9650–9655CrossRefGoogle Scholar
  77. Vision TJ, Brown DG, Tanksley SD (2000) The origins of genomic duplications in Arabidopsis. Science 290:2114–2117CrossRefPubMedGoogle Scholar
  78. Weir BS (1990) Genetic data analysis. Sinauer Publications, SunderlandGoogle Scholar
  79. Wright SI, Bi IV, Schroeder SG, Yamasaki M, Doebley JF, McMullen MD, Gaut BS (2005) The effects of artificial selection on the maize genome. Science 308:1310–1314CrossRefPubMedGoogle Scholar
  80. Yamasaki M, Teanillon MI, Vroh Bi I, Schroeder SG, Sanchez-Villeda H, Doebley JF, Gaut BS, McMulled MD (2005) A large-scale screen for artificial selection in maize identifies candidate agronomic loci for domestication and crop improvement. Plant Cell 17:2859–2872CrossRefPubMedGoogle Scholar
  81. Young ND, Cannon SB, Sato S, Kim D, Cook DR, Town CD, Roe BA, Tabata S (2005) Sequencing the genespaces of Medicago truncatula and Lotus japonicus. Plant Phys 137:1174–1181CrossRefGoogle Scholar
  82. Yu ZH, Stall RE, Vallejos CE (1998) Detection of genes for resistance to common bacterial blight of beans. Crop Sci 38:1290–1296CrossRefGoogle Scholar
  83. Zhang WK, Wang YJ, Luo GZ, Zhang JS, He CY, Wu XL, Gai JY, Chen SY (2004) QTL mapping of ten agronomic traits on the soybean (Glycine max L. Merr.) genetic map and their association with EST markers. Theor Appl Genet 108:1131–1139CrossRefPubMedGoogle Scholar
  84. Zhu H, Kim D-J, Maek J-M, Choi H-K, Ellis LC, Kuester H, McCrombie MW, Pend H-M, Cook DR (2003a) Syntenic relationships between Medicago truncatula and Arabidopsis reveal extensive divergence of genome organization. Plant Physiol 131:1018–1026CrossRefPubMedGoogle Scholar
  85. Zhu YL, Song QJ, Hyten DL, van Tassell CP, Matukumalli LK, Grimm DR, Hyatt SM, Fickus EW, Young ND, Cregan PB (2003b) Single-nucleotide polymorphisms in soybean. Genetics 163:1123–1134PubMedGoogle Scholar
  86. Zhu H, Choi H-K, Cook DR, Shoemaker RC (2005) Bridging model and crop legumes through comparative genomics. Plant Physiol 137:1189–1196CrossRefPubMedGoogle Scholar
  87. Zhu C, Gore M, Buckler ES, Yu J (2008) Status and prospects of association mapping in plants. Plant Genome 1:5–20CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Melody McConnell
    • 1
    • 2
  • Sujan Mamidi
    • 1
    • 2
  • Rian Lee
    • 1
    • 2
  • Shireen Chikara
    • 1
    • 2
  • Monica Rossi
    • 3
  • Roberto Papa
    • 3
  • Phillip McClean
    • 1
    • 2
    Email author
  1. 1.Genomics and Bioinformatics ProgramNorth Dakota State UniversityFargoUSA
  2. 2.Department of Plant SciencesNorth Dakota State UniversityFargoUSA
  3. 3.Dipartimento di Scienze Ambientali e delle Produzioni VegetaliUniversità Politecnica delle MarcheAnconaItaly

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