Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Nierenfunktion im Alter nach radikaler Tumornephrektomie und partieller Nephrektomie

Renal function in the elderly after radical tumor nephrectomy and partial nephrectomy

  • 140 Accesses

  • 1 Citations


Mit steigender Lebenserwartung und dem zunehmenden Einsatz schnittbildgebender Verfahren werden uns im klinischen Alltag immer ältere Patienten mit zufällig diagnostizierten Nierentumoren begegnen. Die vorliegende Arbeit beschäftigt sich mit der Nierenfunktion im Alter nach Tumoroperationen. Hierbei wird die aktuelle Studienlage zusammengefasst und versucht auf Basis dessen dem Leser Hilfestellungen für die Therapieentscheidungen im klinischen Alltag zu geben.


Due to rising life-expectancy and increasing use of tomography more elderly patients with incidental renal tumors are being diagnosed. The current article gives an overview of kidney function after renal surgery in the elderly and the aim is to give assistance in clinical practice for deciding how to adequately treat these patients.

This is a preview of subscription content, log in to check access.

Abb. 1
Abb. 2


  1. 1.

    Robert-Koch-Institut (2008) Krebs in Deutschland. RKI, Berlin

  2. 2.

    Pahernik S, Roos F, Hampel C et al (2006) Nephron sparing surgery for renal cell carcinoma with normal contralateral kidney: 25 years of experience. J Urol 175(6):2027–2031

  3. 3.

    Antonelli A, Cozzoli A, Nicolai M et al (2008) Nephron-sparing surgery versus radical nephrectomy in the treatment of intracapsular renal cell carcinoma up to 7 cm. Eur Urol 53(4):803–809

  4. 4.

    Peycelon M, Hupertan V, Comperat E et al (2009) Long-term outcomes after nephron sparing surgery for renal cell carcinoma larger than 4 cm. J Urol 181(1):35–41

  5. 5.

    Ljungberg B, Cowan NC, Hanbury DC et al (2010) EAU guidelines on renal cell carcinoma: the 2010 update. Eur Urol 58(3):398–406

  6. 6.

    Hillyer SP, Autorino R, Spana G et al (2012) Perioperative outcomes of robotic-assisted partial nephrectomy in elderly patients: a matched-cohort study. Urology 79(5):1063–1067

  7. 7.

    Thomas AA, Aron M, Hernandez AV et al (2009) Laparoscopic partial nephrectomy in octogenarians. Urology 74(5):1042–1046

  8. 8.

    Go AS, Chertow GM, Fan D et al (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351(13):1296–1305

  9. 9.

    Hellenthal NJ, Mansour AM, Hayn MH, Schwaab T (2011) Renal cell carcinoma in octogenarians: nephron sparing surgery should remain the standard of care. J Urol 185(2):415–420

  10. 10.

    Kates M, Badalato G, Pitman M, McKiernan J (2011) Persistent overuse of radical nephrectomy in the elderly. Urology 78(3):555–559

  11. 11.

    Zhou XJ, Saxena R, Liu ZH et al (2008) Renal senescence in 2008: progress and challenges. Int Urol Nephrol 40(3):823–839

  12. 12.

    Verhoest G, Veillard D, Guillé F et al (2007) Relationship between age at diagnosis and clinicopathologic features of renal cell carcinoma. Eur Urol 51(5):1298–1305

  13. 13.

    Huang WC, Levey AS, Serio AM et al (2006) Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol 7(9):735–740

  14. 14.

    Roos FC, Brenner W, Müller M et al (2011) Oncologic long-term outcome of elective nephron-sparing surgery versus radical nephrectomy in patients with renal cell carcinoma stage pT1b or greater in a matched-pair cohort. Urology 77(4):803–808

  15. 15.

    Weight CJ, Larson BT, Fergany AF et al (2010) Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in patients with localized cT1b renal masses. J Urol 183(4):1317–1323

  16. 16.

    Berdjis N, Hakenberg OW, Novotny V et al (2006) Treating renal cell cancer in the elderly. BJU Int 97(4):703–705

  17. 17.

    Lowrance WT, Yee DS, Savage C et al (2010) Complications after radical and partial nephrectomy as a function of age. J Urol 183(5):1725–1730

  18. 18.

    Roos FC, Pahernik S, Melchior SW et al (2008) Renal tumour surgery in elderly patients. BJU Int 102(6):680–683

  19. 19.

    Staehler M, Haseke N, Stadler T et al (2008) Renal surgery in the elderly: morbidity in patients aged > 75 years in a contemporary series. BJU Int 102(6):684–687

  20. 20.

    Denzinger S, Otto W, Burger M et al (2007) Sporadic renal cell carcinoma in young and elderly patients: are there different clinicopathological features and disease specific survival rates? World J Surg Oncol 5:16

  21. 21.

    Hollingsworth JM et al (2007) Five-year survival after surgical treatment for kidney cancer: a population-based competing risk analysis. Cancer 109(9):1763–1768

  22. 22.

    Scoll BJ, Miller DC, Daignault S et al (2009) Age, tumor size and relative survival of patients with localized renal cell carcinoma: a surveillance, epidemiology and end results analysis. J Urol 181(2):506–511

  23. 23.

    Roos FC, Brenner W, Jäger W et al (2011) Perioperative morbidity and renal function in young and elderly patients undergoing elective nephron-sparing surgery or radical nephrectomy for renal tumours larger than 4 cm. BJU Int 107(4):554–561

  24. 24.

    Van Poppel H,, Da Pozzo L, Albrecht W et al (2011) A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma. Eur Urol 59(4):543–552

  25. 25.

    Weight CJ, Lieser G, Larson BT et al (2010) Partial nephrectomy is associated with improved overall survival compared to radical nephrectomy in patients with unanticipated benign renal tumours. Eur Urol 58(2):293–298

  26. 26.

    Huang WC, Elkin EB, Levey AS et al (2009) Partial nephrectomy versus radical nephrectomy in patients with small renal tumors—is there a difference in mortality and cardiovascular outcomes? J Urol 181(1):55–62

  27. 27.

    Sun M, Bianchi M, Trinh QD et al. (2012) Comparison of partial vs radical nephrectomy with regard to other-cause mortality in T1 renal cell carcinoma among patients aged >/= 75 years with multiple comorbidities. BJU Int (Epub ahead of print), doi: 10.1111/j.1464-410X.2012.11254.x

  28. 28.

    Rais-Bahrami S, Guzzo TJ, Jarrett TW et al (2009) Incidentally discovered renal masses: oncological and perioperative outcomes in patients with delayed surgical intervention. BJU Int 103(10):1355–1358

  29. 29.

    Lane BR, Abouassaly R, Gao T et al (2010) Active treatment of localized renal tumors may not impact overall survival in patients aged 75 years or older. Cancer 116(13):3119–3126

  30. 30.

    Kunkle DA, Uzzo RG (2008) Cryoablation or radiofrequency ablation of the small renal mass: a meta-analysis. Cancer 113(10):2671–2680

  31. 31.

    Spaliviero M, Gill IS (2007) Laparoscopic partial nephrectomy. BJU Int 99(5 Pt B):1313–1328

  32. 32.

    Roos FC, Hampel C, Thuroff JW (2009) Renal cancer surgery in the elderly. Curr Opin Urol 19(5):459–464

Download references


Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.

Author information

Correspondence to Dr. S. Mehralivand.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mehralivand, S., Thomas, C., Hampel, C. et al. Nierenfunktion im Alter nach radikaler Tumornephrektomie und partieller Nephrektomie. Urologe 51, 1375–1380 (2012). https://doi.org/10.1007/s00120-012-2919-1

Download citation


  • Nierenzellkarzinom
  • Nierenfunktion
  • Alter
  • Radikale Nephrektomie
  • Organerhaltende Nierentumorresektion


  • Renal cell carcinoma
  • Kidney function
  • Age
  • Radical nephrectomy
  • Organ-sparing surgery