Molekulare Grundlagen alternativer Therapieansätze für das hormonrefraktäre Prostatakarzinom
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Zusammenfassung
In westlichen Ländern liegt eine häufigere Inzidenz des Prostatakarzinoms vor als in asiatischen Gesellschaften. Daher wird eine Prävention des Prostatakarzinoms durch Ernährungsfaktoren wie Phytoöstrogene aus Sojaprodukten diskutiert. Da es bisher keine kurative Therapie für das hormonrefraktäre Prostatakarzinom gibt, sind neue Strategien gefragt, die auch von Phytoöstrogenen oder Histondeacetylasehemmern ausgehen können. Beide Ansätze weisen Parallelen auf, hinsichtlich der Möglichkeit, mit ihnen die in Tumorzellen überaktiven Signalwege des Androgenrezeptors und der IGF-Achse, sowie die Invasivität und die erworbenen Überlebensmechanismen des Tumors wieder zu reduzieren. Diese Expressionsänderungen gehen mit verminderter Tumorzellproliferation und PSA-Sekretion einher. Darüber hinaus konnten durch gezielte Ausschaltung bestimmter Gene mittels RNA-Interferenztechniken Funktionsanalysen hinsichtlich der Bedeutung und der Hierarchie der Expressionsereignisse vollzogen werden.
Schlüsselwörter
Prostatakarzinom Alternative Therapiestrategien Phytoöstrogene Histon-Deacetylase-Inhibitoren (HDACi) RNA-Interferenz (RNAi)Molecular principles of alternative treatment approaches for hormone-refractory prostate cancer
Abstract
Prostate cancer is more frequently diagnosed in men from Western countries than from Asian societies. Therefore, nutritional factors such as phyto-oestrogens from soya are considered to cause this prostate cancer prevention effect. As there is no curative therapy for hormone-refractory prostate cancer, new strategies are in demand which might include phyto-oestrogens or inhibitors of histone deacetylases. Both approaches have in common the potential to reduce the aberrant androgen receptor and IGF receptor signalling. Furthermore, invasiveness and acquired survival strategies of tumours can be diminished. Reduced tumour cell proliferation and PSA secretion coincide with altered gene expression in the aforementioned processes. In addition, selective knock-down of genes by RNA interference afforded functional analyses regarding impact and succession of expression events involved in the beneficial effects caused by phyto-oestrogens and histone deacetylase inhibitors.
Keywords
Prostate cancer Complementary and alternative medicine (CAM) Phyto-oestrogens Histone deacetylase inhibitors (HDACi) RNA interference (RNAi)Notes
Interessenkonflikt
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