Advertisement

Der Radiologe

, Volume 57, Issue 3, pp 204–212 | Cite as

Tumoren der peripheren Nerven

  • Michael HoEmail author
  • Amelie M. Lutz
Leitthema

Zusammenfassung

Hintergrund

Die Unterscheidung zwischen malignen und benignen Tumoren der peripheren Nerven ist im initialen Stadium schwierig. Die Früherkennung der malignen Tumoren ist aufgrund ihrer ungünstigen Prognose jedoch wichtig.

Fragestellungen

Möglichkeiten der MR-Neurographie zur Detektion, Artdiagnostik und klinischem Management von Tumoren der peripheren Nerven anhand bildmorphologischer Charakteristika.

Material und Methode

Zusammenschau der Studienlage mittels PubMed- bzw. MEDLINE-Recherche. Zusätzlich Darlegung teils unveröffentlichter Erkenntnisse aus der eigenen klinischen Beobachtung.

Ergebnisse

Wenn auch nicht pathognomonisch, existieren verschiedene Bildgebungszeichen zur möglichen Unterscheidung verschiedener Tumoren der peripheren Nerven.

Schlussfolgerungen

Die MR-Neurographie ist ein geeignetes bildgebendes Verfahren zur Detektion und ersten Differenzialdiagnose von Tumoren der peripheren Nerven. Zudem kommt ihr besondere Bedeutung bei der Verlaufskontrolle, der gezielten Biopsie und der operativen Planung zu.

Schlüsselwörter

MR-Neurographie Bildgebungszeichen Weichgewebstumoren Nervenscheidentumoren Neurofibromatose 

Tumors of peripheral nerves

Abstract

Background

Differentiation between malignant and benign tumors of peripheral nerves in the early stages is challenging; however, due to the unfavorable prognosis of malignant tumors early identification is required.

Objectives

To show the possibilities for detection, differential diagnosis and clinical management of peripheral nerve tumors by imaging appearance in magnetic resonance (MR) neurography.

Material and methods

Review of current literature available in PubMed and MEDLINE, supplemented by the authors’ own observations in clinical practice.

Results

Although not pathognomonic, several imaging features have been reported for a differentiation between distinct peripheral nerve tumors.

Conclusion

The use of MR neurography enables detection and initial differential diagnosis in tumors of peripheral nerves. Furthermore, it plays an important role in clinical follow-up, targeted biopsy and surgical planning.

Keywords

MR neurography Imaging features Soft tissue neoplasms Nerve sheath tumors Neurofibromatosis 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

M. Ho und A.M. Lutz geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Literatur

  1. 1.
    Murphey MD, Smith WS, Smith SE et al (1999) From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics 19(5):1253–1280CrossRefPubMedGoogle Scholar
  2. 2.
    Chhabra A, Soldatos T, Durand DJ et al (2011) The role of magnetic resonance imaging in the diagnostic evaluation of malignant peripheral nerve sheath tumors. Indian J Cancer 48(3):328–334CrossRefPubMedGoogle Scholar
  3. 3.
    Soldatos T, Fisher S, Karri S et al (2015) Advanced MR imaging of peripheral nerve sheath tumors including diffusion imaging. Semin Musculoskelet Radiol 19(2):179–190CrossRefPubMedGoogle Scholar
  4. 4.
    Mauermann ML, Amrami KK, Kuntz NL et al (2009) Longitudinal study of intraneural perineurioma – a benign, focal hypertrophic neuropathy of youth. Brain 132(Pt 8):2265–2276CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Kransdorf MJ (1995) Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. AJR Am J Roentgenol 164(2):395–402CrossRefPubMedGoogle Scholar
  6. 6.
    Kransdorf MJ (1995) Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol 164(1):129–134CrossRefPubMedGoogle Scholar
  7. 7.
    Hornick JL, Fletcher CD (2005) Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol 29(7):859–865CrossRefPubMedGoogle Scholar
  8. 8.
    Woertler K (2010) Tumors and tumor-like lesions of peripheral nerves. Semin Musculoskelet Radiol 14(5):547–558CrossRefPubMedGoogle Scholar
  9. 9.
    Stark AM, Hugo HH, Buhl R et al (2002) Tumoren peripherer Nerven. Dtsch Arztebl 99(14):A–928Google Scholar
  10. 10.
    Abreu E, Aubert S, Wavreille G et al (2013) Peripheral tumor and tumor-like neurogenic lesions. Eur J Radiol 82(1):38–50CrossRefPubMedGoogle Scholar
  11. 11.
    Le LQ, Liu C, Shipman T (2001) Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. AJR Am J Roentgenol 176(1):75–82CrossRefGoogle Scholar
  12. 12.
    Lin J, Martel W (2001) Cross-sectional imaging of peripheral nerve sheath tumors: characteristic signs on CT, MR imaging, and sonography. AJR Am J Roentgenol 176(1):75–82CrossRefPubMedGoogle Scholar
  13. 13.
    Ahlawat S, Chhabra A, Blakely J (2014) Magnetic resonance neurography of peripheral nerve tumors and tumorlike conditions. Neuroimaging Clin N Am 24(1):171–192CrossRefPubMedGoogle Scholar
  14. 14.
    Macarenco RS, Ellinger F, Oliveira AM (2007) Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med 131(4):625–636PubMedGoogle Scholar
  15. 15.
    Woodruff JM (1993) The pathology and treatment of peripheral nerve tumors and tumor-like conditions. CA Cancer J Clin 43(5):290–308CrossRefPubMedGoogle Scholar
  16. 16.
    Roux A, Tréguier C, Bruneau B et al (2012) Localized hypertrophic neuropathy of the sciatic nerve in children: MRI findings. Pediatr Radiol 42(8):952–958CrossRefPubMedGoogle Scholar
  17. 17.
    Ogose A, Hotta T, Morita T et al (1999) Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis. Skeletal Radiol 28(4):183–188CrossRefPubMedGoogle Scholar
  18. 18.
    Jee WH, Oh SN, McCauley T et al (2004) Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol 183(3):629–633CrossRefPubMedGoogle Scholar
  19. 19.
    Li CS, Huang GS, Wu HD et al (2008) Differentiation of soft tissue benign and malignant peripheral nerve sheath tumors with magnetic resonance imaging. Clin Imaging 32(2):121–127CrossRefPubMedGoogle Scholar
  20. 20.
    Isobe K, Shimizu T, Akahane T et al (2004) Imaging of ancient schwannoma. AJR Am J Roentgenol 183(2):331–336CrossRefPubMedGoogle Scholar
  21. 21.
    Chhabra A, Thakkar RS, Andreisek G et al (2013) Anatomic MR imaging and functional diffusion tensor imaging of peripheral nerve tumors and tumorlike conditions. AJNR Am J Neuroradiol 34(4):802–807CrossRefPubMedGoogle Scholar
  22. 22.
    Demehri S, Belzberg A, Blakeley J et al (2014) Conventional and functional MR imaging of peripheral nerve sheath tumors: initial experience. AJNR Am J Neuroradiol 35(8):1615–1620CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Zou C, Smith KD, Liu J et al (2009) Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg 249(6):1014–1022CrossRefPubMedGoogle Scholar
  24. 24.
    Porter DE, Prasad V, Foster L et al (2009) Survival in malignant peripheral nerve sheath tumours: a comparison between sporadic and neurofibromatosis type 1‑associated tumours. Sarcoma 2009:756395CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Descamps MJ, Barrett L, Groves M et al (2006) Primary sciatic nerve lymphoma: a case report and review of the literature. J Neurol Neurosurg Psychiatr 77(9):1087–1089CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Bakst R, Jakubowski A, Yahalom J (2011) Recurrent neurotropic chloroma: report of a case and review of the literature. Adv Hematol 2011:854240CrossRefPubMedGoogle Scholar
  27. 27.
    Kim DH, Murovic JA, Tiel RL et al (2005) A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg 102(2):256–266CrossRefPubMedGoogle Scholar
  28. 28.
    Manenti G, Raguso M, D’Onofrio S (2013) Pancoast tumor: the role of magnetic resonance imaging. Case Rep Radiol 2013(2013):479120PubMedPubMedCentralGoogle Scholar
  29. 29.
    Weishaupt D, Treiber K, Kundert HP et al (2003) Morton neuroma: MR imaging in prone, supine, and upright weight-bearing body positions. Radiology 226(3):849–856CrossRefPubMedGoogle Scholar
  30. 30.
    Zanetti M, Strehle JK, Kundert HP et al (1999) Morton neuroma: effect of MR imaging findings on diagnostic thinking and therapeutic decisions. Radiology 213(2):583–588CrossRefPubMedGoogle Scholar

Copyright information

© Springer Medizin Verlag Berlin 2017

Authors and Affiliations

  1. 1.Institut für Diagnostische RadiologieUniversitätsklinikum ZürichZürichSchweiz
  2. 2.Department of RadiologyStanford University School of MedicineStanfordUSA

Personalised recommendations