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Der Radiologe

, Volume 54, Issue 2, pp 145–151 | Cite as

Strahlentherapeutische Konzepte beim CUP-Syndrom

  • D. KrugEmail author
  • J. Debus
  • F. Sterzing
Leitthema

Zusammenfassung

Hintergrund

Das Cancer-of-unknown-primary(CUP)-Syndrom fasst eine Gruppe von Erkrankungen zusammen, die durch eine ausgeprägte Heterogenität hinsichtlich Ätiologie, Therapie und Prognose geprägt sind.

Ziel der Arbeit

Darstellung der Rolle der Strahlentherapie beim CUP-Syndrom.

Material und Methoden

Systematische Literaturrecherche und Erläuterung der Behandlungsoptionen.

Ergebnisse und Diskussion

Die Strahlentherapie ist beim CUP-Syndrom sowohl in adjuvanten und definitiven Therapiekonzepten wie auch in palliativer Intention etabliert. Technisch innovative Verfahren wie die intensitätsmodulierte Radiotherapie und die stereotaktische Bestrahlung im Körperstammbereich ermöglichen eine Vergrößerung der therapeutischen Breite. Eine leistungsfähige und moderne radiologische und nuklearmedizinische Diagnostik stellt die Grundlage jeder strahlentherapeutischen Intervention dar.

In Verbindung mit operativen und medikamentösen Ansätzen eröffnet die Strahlentherapie therapeutische Möglichkeiten zum organerhaltenden und kurativen Vorgehen. In der palliativen Situation bietet die Strahlentherapie Optionen zur Verbesserung und Bewahrung von Lebensqualität.

Schlussfolgerung

Strahlentherapeutische Verfahren stellen einem unverzichtbaren Bestandteil des interdisziplinären Behandlungskonzepts für Patienten mit CUP-Syndrom dar. Therapieentscheidungen sollten im interdisziplinären Kontext getroffen werden.

Schlüsselwörter

Behandlungsoptionen Lebensqualität Interdisziplinärer Kontext „Stereotactic body radiotherapy“ (SBRT) Intensitätsmodulierte Radiotherapie (IMRT) 

Radiotherapeutic concepts in cancer of unknown primary site

Abstract

Background

The term cancer of unknown primary (CUP) encompasses a group of entities which differ to a great extent regarding etiology, prognosis and therapeutic management.

Objectives

The aim of the study was an elaboration of the role of radiotherapy in CUP syndrome.

Material and methods

Systematic literature search and specification of the available treatment options.

Results

Radiotherapy is an integral part of interdisciplinary management approaches for patients with CUP in both curative and palliative situations. Radio-oncological techniques, such as intensity-modulated radiotherapy and stereotactic body radiotherapy increase the therapeutic window. Modern diagnostic modalities from radiology and nuclear medicine are the cornerstone of radiotherapeutic interventions, especially in terms of target volume definition and pretherapeutic staging. In the interdisciplinary setting radiation oncology offers the possibility of curative and often organ preserving approaches in patients with axillary and cervical CUP. In addition, improvement and preservation of quality of life can be achieved in patients with metastatic disease.

Conclusion

Radiation oncology is a crucial component of the interdisciplinary management of patients with CUP. Therapeutic decisions in patients with CUP should be made in an interdisciplinary setting.

Keywords

Treatment options Quality of life Interdisciplinary context Stereotactic body radiotherapy Intensity-modulated radiotherapy 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt. D. Krug, J. Debus, F. Sterzing geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Klinik für Radioonkologie und StrahlentherapieUniversitätsklinikum HeidelbergHeidelbergDeutschland

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