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Der Radiologe

, Volume 53, Issue 3, pp 200–208 | Cite as

MR-gesteuerter fokussierter Ultraschall

Aktuelle und potenzielle Indikationen
  • C.G. Trumm
  • A. Napoli
  • M. Peller
  • D.-A. Clevert
  • R. Stahl
  • M. Reiser
  • M. Matzko
Leitthema

Zusammenfassung

Radiologische Standardverfahren

MRT-gesteuerter hochintensiver fokussierter Ultraschall (MRgFUS bzw. MR-HIFU) ist ein nichtinvasives Verfahren zur präzisen Thermoablation eines Zielgewebes. Bei dieser Methode werden benachbarte Gewebe und Organe geschont.

Methodische Innovationen

Die Kombination des fokussierten Ultraschalls (FUS) mit der MRT zwecks Planung und Monitoring (nahezu) in Echtzeit sowie zur Erfolgskontrolle von Behandlungen trägt wesentlich zur Sicherheit dieser Methode bei.

Bewertung

MRgFUS ist klinisch v. a. zur Behandlung von symptomatischen Uterusmyomen etabliert, gefolgt von der palliativen Ablation von Knochenmetastasen. Weitere vielversprechende Anwendungsgebiete des MRgFUS sind die Adenomyose des Uterus, die Behandlung von Prostata-, Mamma- und Lebertumoren sowie der intrakranielle Einsatz.

Schlüsselwörter

Hochintensiver fokussierter Ultraschall Magnetresonanztomographie Ablation Transducer Sonikation 

MR-guided focused ultrasound

Current and future applications

Abstract

Standard radiological methods

High-intensity focused ultrasound (synonyms FUS and HIFU) under magnetic resonance imaging (MRI) guidance (synonyms MRgFUS and MR-HIFU) is a completely non-invasive technology for accurate thermal ablation of a target tissue while neighboring tissues and organs are preserved.

Methodical innovations

The combination of FUS with MRI for planning, (near) real-time monitoring and outcome assessment of treatment markedly enhances the safety of the procedure.

Achievements

The MRgFUS procedure is clinically established in particular for the treatment of symptomatic uterine fibroids, followed by palliative ablation of painful bone metastases. Furthermore, promising results have been shown for the treatment of adenomyosis, malignant tumors of the prostate, breast and liver and for various intracranial applications, such as thermal ablation of brain tumors, functional neurosurgery and transient disruption of the blood-brain barrier.

Keywords

High-intensity focused ultrasound Magnetic resonance imaging Ablation Transducer Sonikation 

Notes

Interessenkonflikt

Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • C.G. Trumm
    • 1
  • A. Napoli
    • 2
  • M. Peller
    • 1
  • D.-A. Clevert
    • 1
  • R. Stahl
    • 1
  • M. Reiser
    • 1
  • M. Matzko
    • 3
  1. 1.Institut für Klinische RadiologieKlinikum der Ludwig-Maximilians-Universität München-GroßhadernMünchenDeutschland
  2. 2.Abteilung für Radiologie (Department of Radiological Sciences), MRgFUS and Cardiovascular Imaging UnitSapienza Universität RomRomItalien
  3. 3.Abteilung für diagnostische und interventionelle RadiologieKlinikum DachauDachauDeutschland

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