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Der Radiologe

, Volume 48, Issue 6, pp 544–552 | Cite as

Multiple Sklerose

  • I.Q. Grunwald
  • A.L. Kühn
  • M. Backens
  • K. Shariat
  • P. Kostopoulos
  • P. Papanagiotou
Leitthema

Zusammenfassung

Die Multiple Sklerose (MS) ist die häufigste chronisch-entzündliche Erkrankung des Myelins mit eingesprengten Läsionen im Bereich der weißen Substanz des zentralen Nervensystems. Die Magnetresonanztomographie (MRT) hat bei der Diagnosestellung und Verlaufskontrolle eine Schlüsselrolle. Dieser Artikel befasst sich mit Hauptcharakteristika der MR-Bildbebung.

Schlüsselwörter

Myelin Magnetresonanztomographie (MRT) Weiße Substanz 

Multiple sclerosis

Abstract

Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI.

Keywords

Myelin Magnetic resonance imaging (MRI) White matter 

Notes

Interessenkonflikt

Die korrespondierende Autorin gibt an, dass kein Interessenkonflikt besteht.

Literatur

  1. 1.
    Moreira MA, Tilbery CP, Lana-Peixoto MA et al. (2002) Historical aspects of multiple sclerosis. Rev Neurol 34(4): 379–383PubMedGoogle Scholar
  2. 2.
    Ascherio A, Munger KL (2007) Environmental risk factors for multiple sclerosis. Part II: noninfectious factors. Ann Neurol 61(6): 504–513PubMedCrossRefGoogle Scholar
  3. 3.
    Hestvik AL, Vartdal F, Fredriksen AB et al. (2007) cells from multiple sclerosis patients recognize multiple epitopes on Sel IgG. Scand J Immunol 66(4): 393–401PubMedCrossRefGoogle Scholar
  4. 4.
    Hernán MA, Jick SS, Olek MJ, Jick H (2004) Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective study. Neurology 63(5): 838–842PubMedGoogle Scholar
  5. 5.
    Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33: 1444–1452PubMedGoogle Scholar
  6. 6.
    Jackson JA, Leake DR, Schneiders NJ et al. (1985) Magnetic resonance imaging in multiple sclerosis: results in 32 cases. Am J Neuroradiol 6: 171–176PubMedGoogle Scholar
  7. 7.
    Sheldon JJ, Siddharthan R, Tobias J et al. (1985) MR imaging of multiple sclerosis: comparison with clinical and CT examinations in 74 patients. Am J Neuroradiol 6: 683–690Google Scholar
  8. 8.
    Edwards MK, Farlow MR, Stevens JC (1986) Cranial MR in spinal cord MS: diagnosing patients with isolated cord symptoms. Am J Neuroradiol 7: 1003–1006PubMedGoogle Scholar
  9. 9.
    Nesbit GM, Forbes GS, Scheithauer BW et al. (1991) Multiple sclerosis: histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy. Radiology 180: 467–474PubMedGoogle Scholar
  10. 10.
    Osborn AG, Harnsberger HR, Smoker WRK et al. (1990) Multiple sclerosis in adolescents: CT and MR findings. Am J Neuroradol 11: 489–494Google Scholar
  11. 11.
    Hardmeier M, Wagenpfeil S, Freitag P et al. (2005) European IFN-1a in Relapsing MS Dose Comparison Trial Study Group. Rate of brain atrophy in relapsing MS decreases during treatment with IFNbeta-1a. Neurology. 64(2): 236–240Google Scholar
  12. 12.
    Sahraian MA, Radue E-W (2008) MRI atlas of MS lesions. Springer, Berlin Heidelberg New YorkGoogle Scholar
  13. 13.
    Dastidar P, Heinonen T, Lehtimäki T et al. (1999) Volumes of brain atrophy and plaques correlated with neurological disability in secondary progressive multiple sclerosis. J Neurol Sci 165(1): 36–42PubMedCrossRefGoogle Scholar
  14. 14.
    Fisher E, Rudick RA, Simon JH et al. (2002) Eight-year follow-up study of brain atrophy in patients with MS. Neurology 59(9): 1412–1420PubMedGoogle Scholar
  15. 15.
    Benedict RH, Zivadinov R (2007) Reliability and validity of neuropsychological screening and assessment strategies in MS. J Neurol 254 [suppl 2]: II22–II25 (review)Google Scholar
  16. 16.
    Drayer B, Burger P, Hurwitz B et al. (1987) Reduces signal intensity on MR images of thalamus and putamen in multiple sclerosis: increased iron content? Am J Neuroradiol 8: 413–419Google Scholar
  17. 17.
    Benedict RH, Bobholz JH (2007) Multiple sclerosis. Semin Neurol 27(1): 78–85 (review)PubMedCrossRefGoogle Scholar
  18. 18.
    Neema M, Stankiewicz J, Arora A et al. (2007) MRI in multiple sclerosis: what’s inside the toolbox? Neurotherapy 4(4): 602–617CrossRefGoogle Scholar
  19. 19.
    Whittall KP, Mackay AL, Li DKB et al. (2002) Normal-appearing white matter in multiple sclerosis has heterogeneous, diffusely prolonged T2. Magn Reson Med 47: 403–408PubMedCrossRefGoogle Scholar
  20. 20.
    Barkhof F, Valk J, Hommes OR et al. (1992) Meningeal Gd-DTPA enhancement in multiple sclerosis. Am J Neuroradiol 13: 397–400PubMedGoogle Scholar
  21. 21.
    Bonneville F, Moriarty DM, Li BSY et al. (2002) Whole-brain N-acetylaspartate concentration: correlation with T2-weighted lesion volume and expanded disability status scale score in cases of relapsing-remitting multiple sclerosis. Am J Neuroradiol 23: 371–375PubMedGoogle Scholar
  22. 22.
    Mader I, Roser W, Kappos L et al. (2000) Serial proton MR spectroscopy of contrast- enhancing multiple sclerosis plaques: absolute metabolic values over 2 years during a clinical pharmacological study. Am J Neuroradiol 21: 1220–1227PubMedGoogle Scholar
  23. 23.
    Papanagiotou P, Grunwald IQ, Farmakis G et al. (2008) MS-Spektroskopie bei entzündlichen Hirnerkrankungen. Schmerz, im DruckGoogle Scholar

Copyright information

© Springer Medizin Verlag 2008

Authors and Affiliations

  • I.Q. Grunwald
    • 1
  • A.L. Kühn
    • 1
  • M. Backens
    • 1
  • K. Shariat
    • 2
  • P. Kostopoulos
    • 3
  • P. Papanagiotou
    • 1
  1. 1.Abteilung für Diagnostische und Interventionelle Neuroradiologie, Radiologische KlinikUniversität des SaarlandesHomburg/SaarDeutschland
  2. 2.Klinik für NeurochirurgieUniversität des SaarlandesHomburg/SaarDeutschland
  3. 3.Klinik für NeurologieUniversität des SaarlandesHomburg/SaarDeutschland

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